• News
• Analysis Tinnitus-Questionaire
• Actual Literature
• How can EUTi help?
• We ask you
• EUTI Information
  • Foundation
  • Board
  • Aims
  • Statutes

Actual Literature

New

NOTE: We would appreciate, if any experts could comment on the articles.
Please mail to: EUTi

Recently published literature and results of the latest research
Source: Tinnitus Research Initiative

Gerhard GOEBEL, U. FLOETZINGER (2008)
Pilot study to evaluate psychiatric co-morbidity in tinnitus patients with and without hyperacusis. Audiological Medicine 6: 74-81
Clinic Roseneck, Hospital for Behavioural Medicine, Prien; in cooperation with the University of Munich, Germany
The relationship between hyperacusis with chronic tinnitus and psychiatric disorders has long been ignored. A prevalence of hyperacusis in 59% of the tinnitus patients was found using the Structured Tinnitus-Interview (STI). Twenty-four percent of the subgroup noticed the hyperacusis before the tinnitus had begun. Study participants were 163 consecutive inpatients with chronic tinnitus. A Tinnitus Questionnaire assessed the degree of severity of the tinnitus. Hyperacusis was assessed in a structured interview, with the Hyperacusis Questionnaire and by Loudness Discomfort Levels. We conducted a psychiatric interview to check for acute psychiatric disorders, and additional questionnaires assessed different psychosomatic and psychiatric symptoms. In 69% of the patients there was an acute psychiatric diagnosis present. Because precise criteria for sound intolerance have seldom been defined, we computed the cut-off points for the German "Questionnaire on Hypersensitivity to Sounds" (GÜF), Uncomfortable Loudness Levels to tones (ULLt) and to broad band noises (ULLn). Our hypothesis that affective and anxiety disorders correlate more highly with a diagnosis of tinnitus with hyperacusis was confirmed. This was particularly true when we diagnosed hyperacusis using the GÜF or the ULL. It is assumed that in most cases, the hyperacusis does not contribute to the psychiatric disorder, but that the existing disorders present a risk factor for the development of hyperacusis.

I Pharmacotherapy

Antidepressants for patients with tinnitus.
Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003853.
Baldo P, Doree C, Lazzarini R, Molin P, McFerran DJ
Centro di Riferimento Oncologico--CRO Aviano (PN) Italy, Hospital Pharmacy, Via Pedemontana Occidentale,12, Aviano (PN), Friuli-Venezia-Giulia, Italy. pbaldo@cro.it
Background: Tinnitus is described as the perception of sound or noise in the absence of real acoustic stimulation. It has been compared with chronic pain, and may be associated with depression or depressivesymptoms which can affect quality of life and the ability to work. Antidepressant drugs have been used to treat tinnitus in patients with and without depressive symptoms.
Objectives: To assess the effectiveness of antidepressants in the treatment of tinnitus and to ascertain whether any benefi t was due to a direct tinnitus effect or a secondary effect due to treatment of concomitantdepressive states.
Search Strategy: We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) The Cochrane Library Issue 1, 2006); MEDLINE (January 1951 to 2006); EMBASE (1974 to 2006), CINAHL (to 2006), PSYCINFO (to 2006), LILACS (to 2006), and Cambridge Scientifi c Abstracts. The date of the most recent search was March2006.
Selection Criteria: Randomised controlled clinical studies of antidepressant drugs versus placebo in patients with tinnitus.
Data collection and analysis: The studies retrieved were critically appraised and data extracted independently by two authors. Where necessary study authors were contacted for further information.
Main results: Five trials involving 525 patients were included. Four of these trials looked at the effect of tricyclic antidepressants on tinnitus, investigating 405 patients. One trial investigated the effect of a selective serotonin reuptake inhibitor (SSRI) in a group of 120 patients. No trials involving other antidepressant agents met the inclusion criteria. Only the trial using the SSRI drug met the highest quality standard.None of the other included trials met the highest quality standard, due to use of inadequate outcome measures, large drop out rates or failure to separate the effects on tinnitus from the effects on symptoms of anxiety and depression. All the trials assessing tricyclic antidepressants suggested that there was a slight improvement in tinnitus but these effects may have been attributable to methodological bias.The trial that investigated the SSRI drug found no overall improvement in any of the validated outcome measures that were used in the study although there was possible benefi t for a subgroup that received higher doses of the drug. This observation merits further investigation. Reports of side effects including sedation, sexual dysfunction and dry mouth were common. Authors' Conclusion: There is insufficient evidence to say that antidepressant drug therapy improves tinnitus. (because of the special interest of this publication it has been included even if it was published in 2006)

Clinical development of SPI-1005, an otoprotectant for noise induced hearing loss.
(Abstract of ARO Meeting Denver, Colorado)
Jonathan Kil, Bret MacPherson, Carol Pierce, Eric Lynch
Sound Pharmaceuticals, Inc.Ebselen (SPI-1005), an oral small molecule GPx mimic, has been shown to provide signifi cant protection from TTS and PTS in F344 rats (Lynch et al., 2004, Lynch et al., 2005), Sprague Dawley Rats (Park etal., ARO Abst. 2006) and Guinea Pigs (Pourbahkt and Yamasoba 2003, Yamasoba et al., 2005) when dosed in the range of 8-30 mg/kg. Our current efforts are now focused on translating these pre-clinical findings into a therapeutic for the prevention and treatment of noise induced hearing loss in humans.
We have completed a phase I study of SPI-1005 capsules in 32 normal healthy volunteers to determine the safety, toxicity, ADME, and Pk. Dose escalation was performed in 4 groups ranging from 200 to 1600 mg po. Subjects were followed in house for a period of 72 hours. Multiple EKGs, orthostatic vitals, Chem20, and CBCs were taken during the period of clinical observation. No signifi cant adverse events were noted in 24 drug treated and 8 placebo treated individuals. Pk analysis of ebselen and its metabolites was performed using WinNonlin®5.1 from plasma and urine samples analyzed by LC-MS/MS. These results closely matched the Pk analysis of total selenium in plasma samples by ICP-MS from the same treated individuals. The plasma Pk of ebselen in these human subjects was similar to that in nonhuman primates dosed with SPI-1005 at comparable levels (10mg/kg). Phase II safety and efficacy trials will be performed in military populations exposed to noise during weapons training. Historically, a Significant Threshold Shift (STS) occurs even with the use of hearing protective devices.
The Clinical trial design for these phase II studies will be discussed along with primary and secondary endpoints using STS and the Tinnitus Handicap Inventory.

Effects of Gacyclidine Extracochlear Perfusion on Tinnitus in Humans and Intracochlear Perfusion on ABR Thresholds in Guinea Pigs.
(Abstract of ARO Meeting Denver, Colorado)
Gentiana I Wenzel1, Hubert H Lim1, Timo Stöver1, Thomas Lobl2, John Schloss2, Burkard Schwab1, Thomas Lenarz1
1Medizinische Hochschule Hannover, 2NeuroSystec Gacyclidine is a highly specific NMDA receptor antagonist with neuroprotective properties. In guinea pigs, administration of gacyclidine (adsorbed to Gelfoam) into the round window niche or as a bolus injection into the cochlea suppressed salicylate-induced tinnitus. Thus, we investigated in humans and animals if gacyclidine could provide a safe and effective treatment for tinnitus. We administered gacyclidine as a compassionate treatment in unilateral deaf patients with tinnitus. These patients experienced temporary relief from tinnitus after constant perfusion of gacyclidine into the round window niche for 40-60 hours. This demonstrated that gacyclidine has the potential to suppress tinnitus. However, controlled and long-term delivery of the drug will be necessary for effective treatment.
Since the main candidates for this therapy will be hearing patients, we needed to assess whether chronic administration of this drug would compromise hearing performance. Thus, we measured the effects of chronic intracochlear gacyclidine perfusion on frequency-specific ABR thresholds in guinea pigs. Guinea pigs were implanted with osmotic pumps that delivered 0.5 µL/h of 0.3 mM gacyclidine for 9 days via a catheter inserted through the round window membrane. The concentration and rate of drug delivery were selected to provide a dose that was substantially higher than is expected for tinnitus control in humans. Frequency-specific ABRs (1- 40 kHz, 10-80 dB SPL in 10dB steps) were recorded before implantation and compared with those obtained after drug administration. No signifi cant changes in ABR thresholds were observed suggesting that prolonged administration of gacyclidine for tinnitus treatment should be safe in terms of hearing preservation.
Further studies investigating the toxicological effects of different dosages and durations are under way to ensure the safety of the drug for long-term human use and to warrant clinical trials.

Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy.
Laryngoscope. 2007 Jan;117(1):3-15. Review.
Haynes DS, O'Malley M, Cohen S, Watford K, Labadie RF
Vanderbilt University Medical Center/The Otology Group of Vanderbilt, Nashville, Tennessee 37232, USA. david.haynes@vanderbilt.edu
Objective: Intratympanic steroids are increasingly used in the treatment of inner ear disorders, especially in patients with sudden sensorineural hearing loss (SNHL) who have failed systemic therapy. We reviewed our experience with intratympanic steroids in the treatment of patients with sudden SNHL todetermine overall success, morbidity, and prognostic factors.
Hypothesis: Intratympanic steroids have minimal morbidity and the potential to have a positive effect on hearing recovery in patients with sudden SNHL who have failed systemic therapy.
Study design: The authors conducted a retrospective review.
Methods: Patients presenting with sudden SNHL defi ned as a rapid decline in hearing over 3 days or less affecting 3 or more frequencies by 30 dB or greater who underwent intratympanic steroids therapy (24 mg/mL dexamethasone) were reviewed. Excluded were patients with Meniere disease, retrocochlear disease, autoimmune HL, trauma, fluctuating HL, radiation-induced HL, noise-induced HL, or any other identifiable etiology for sudden HL. Patients who showed signs of fluctuation of hearing after injection were excluded. Pretreatment and posttreatment audiometric evaluations including pure-tone average (PTA) and speech reception threshold (SRT) were analyzed. Patient variables as they related to recovery were studied and included patient age, time to onset of therapy, status of the contralateral ear, presence of diabetes, severity of HL, and presence of associated symptoms (tinnitus, vertigo). A 20-dB gain in PTA or a 20% improvement in SDS was considered significant.
Results: Forty patients fi t the criteria for inclusion in the study. The mean age of the patients was 54.8 years with a range from 17 to 84 years of age. Overall, 40% (n = 16) showed any improvement in PTA or SDS. Fourteen (35%) men and 26 (65%) women were included. Using the criteria of 20-dB improvement in PTA or 20% improvement in SDS for success, 27.5% (n = 11) showed improvement. The mean number of days from onset of symptoms to intratympanic therapy was 40 days with a range of 7 days to 310 days. A statistically signifi cant difference was noted in those patients who received earlier injection (P = .0008, rank sum test). No patient receiving intratympanic dexamethasone after 36 days recovered hearing using 20-dB PTA decrease or a 20% increase in discrimination as criteria for recovery. Twelve percent (n = 5) of patients in the study had diabetes with 20% recovering after intratympanic dexamethasone (not significantly different from nondiabetics at 28.6%, Fisher exact test, P = 1.0). Comparison to other studies that used differing steroid type, concentration, dosing schedule, inclusion criteria, and criteria for success revealed, in many instances, a similar overall recovery rate.
Conclusions: Difficulty in proving efficacy of a single modality is present in all studies on SNHL secondary to multiple treatment protocols, variable rates of recovery, and a high rate of spontaneous recovery.
Forty percent of patients showed some improvement in SDS or PTA after treatment failure. When criteria of 20-dB PTA or 20% is considered to define improvement, the recovery rate was 27.5%. Modest improvement is seen with the current protocol of a single intratympanic steroid injection of 24 mg/mL dexamethasone in patients who failed systemic therapy. Dramatic hearing recovery in treatment failures was rarely encountered. No patient showed signifi cant benefi t from intratympanic steroids after 36 days when using this protocol for idiopathic sudden SNHL. If patients injected after 6 weeks are excluded from the study, the improvement rate increases from 26.9% to 39.3%. Earlier intratympanic injection had a significant impact on hearing recovery, although with any therapeutic intervention for sudden SNHL, early success may be attributed to natural history. If we further exclude seven patients treated with intratympanic steroids within 2 weeks of the onset of symptoms (i.e., study only those patients treated with intratympanic dexamethasone between 2 and 6 weeks after onset of symptoms), still, 26% improved by 20 dB or 20% SDS. The recovery rates after initial systemic failure are higher than would be expected in this treatment failure group given our control group (9.1%) and literature review. These findings indicate a positive effect from steroid perfusion in this patient population.

Modeling drug dispersion in the inner ear fluids: The importance of accurate 3D anatomical studies.
(Abstract of ARO Meeting Denver, Colorado)
Alec N. Salt1, Timothy A. Holden1, Ruth M. Gill1, Stefan K. Plontke2 1Washington University School of Medicine, 2University of Tubingen Locally-applied drugs are increasingly being used for the clinical treatment of inner ear disorders such as Meniere's disease, sudden hearing loss and tinnitus. Knowledge of the dosages achieved and where in the ear the drugs reach is essential to optimize therapies. In animals, experimental studies have shown that drug spread in the inner ear is dominated by diffusion that takes place slowly along the fluid spaces. Quantitative interpretation of experimental measurements and prediction of the likely drug distribution in humans is only possible through quantitative computer models. Whether the model is a simple 1D representation of a scala or a sophisticated 3D representation of the inner ear, the calculations are highly dependent on the dimensions of the compartments that are used. With more sophisticated models, the interactions of each compartment with adjacent structures also need to be incorporated. At present, models are restricted by the limited availability of anatomic descriptions of the ear. Quantitative anatomic studies have become more feasible with the increased availability of 3D reconstruction programs and the increased capabilities of desktop computers. Data sets for analysis can be obtained from serial histological sections, magnetic resonance microscopy (MRM), computed tomography (CT) and orthogonal plane fl uorescence optical sectioning (OPFOS). Each of these methods has different capabilities in terms of which tissues can be detected and at what resolution. As the voxel resolution of the methods increases, the effort required to segment structures increases dramatically, limiting the number of specimens that can be analyzed. Other limitations arise from tissue shrinkage and long preparation times. In some applications, combining structures segmented from different data sets, such as bone from a CT scan and soft tissues from an OPFOS scan can aid the analysis. The long-term goal of this work is to develop a 3D model of the ear, through which drug dispersal can be calculated based on the anatomic communications present and incorporating the transport and permeability properties of tissue boundaries (Supported by NIH/NIDCD grants DC01368 (AS) and DC000581 (TH) and BMBF grant 0313844b (SP)).

A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium.
Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-77
Khan M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, Schmidt FP, Klapp BF, Reisshauer A, Mazurek B
Department of Otorhinolaryngology, Charite-University Medicine Berlin, Berlin, Germany.
Objective: To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium.
Study Design: A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status.
Results: The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevatedafter medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and signifi cant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed. Conclusion: In patients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitusexpression.
Significance: This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium.

Preliminary Data evaluating the Effect of Gabapentin on Auditory Temporal Resolution characterized by a Gap Detection Task in Gerbils.
(Abstract of ARO Meeting Denver, Colorado)
Otto Gleich, Juergen-Theodor Fraenzer, Jürgen Strutz
University of Regensburg
Impaired auditory temporal processing is improved by the drug ?-vinyl-GABA (Sabril) that increases GABA levels in the brain (Gleich et al., 2003, Neuroreport 14:1877-1880). However, Sabril can reduce the visual field. Thus we began evaluating the anticonvulsant Gabapentin (GP). GP was effective in the treatment of certain forms of tinnitus, where GABA mechanisms have repeatedly been implicated (Bauer and Brozoski, 2001, JARO 2:54-64; 2006, Laryngoscope 116: 675-681).
In each animal threshold for an 800 ms broad band noise pulse was determined. The noise pulse was subsequently used as a carrier for the gap with a level set 30 dB above each individual's threshold. GP was administered in the drinking water at a dose of 350 mg/kg/day. Testing was performed 1-2 hours after GP intake. Gap detection thresholds were determined, before, during and at least two weeks after cessation of GP administration for 5 young (8-13 months) and 10 old (27-37 months) gerbils. A two way repeated measure ANOVA using age and treatment as factors revealed a signifi cantly higher mean gap detection threshold for old (3.1 ms) as compared to young (2.0 ms) gerbils (p = 0.019). Mean gap detection threshold during GP treatment (2.9 ms) was slightly higher compared to thresholds determined before (2.5 ms) and after GP treatment (2.3 ms), however, these differences were not significant (p = 0.212) and there was no interaction between age and treatment (p = 0.923). These preliminary data provide no evidence for a benefi cial effect of GP on temporal resolution, if anything, the group mean data suggest that performance may deteriorate during GP treatment. In contrast to initial expectations, GP has no effect on GABA receptors, enzymes or transporters (Errington et al., 2005, Curr. Top. Med. Chem. 5, 15-30) and consequently cannot compensate age dependent declines in the GABA system (We thank S. Kopetschek and C. Wögerbauer for help with the behavioralexperiments. Supported by the DFG Str275/4-5).

Sulpiride plus hydroxyzine decrease tinnitus perception.
Auris Nasus Larynx. 2007 Mar;34(1):23-7. Epub 2006 Nov 21.
Lopez-Gonzalez MA, Moliner-Peiro F, Alfaro-Garcia J, Esteban-Ortega F
Otorhinolaryngology Department, Virgen del Rocio University Hospital, Seville, Spain. malopez@cica.es
Objectives: The aim of the study is to confi rm the effectiveness of sulpiride and hydroxyzine in tinnitus patients. The administration of sulpiride, a D2 antagonist of dopamine receptors, together with hydroxyzine, a subcortical sedative, covers the areas of tinnitus perception.
Methods: A prospective, randomized, single blinded, placebo-control study was done in general otorhinolaryngology consultations for 2002-2004 in Seville and Zaragoza (Spain). One hundred and fifty patients consulted for subjective tinnitus. They were included randomly in three groups of 50. A group took sulpiride (50 mg/8 h) alone, other the same dose of sulpiride plus hydroxyzine (25 mg/12 h), and the third placebo (lactose), for 1 month. One hundred and twenty-two patients completed the study. Clinical history, tonal audiometry, tympanometry, and tinnitometry were done in the beginning and end of the study. Subjective Grading of Tinnitus Perception and visual analogical scale (0-10) were done for result evaluation.
Results: Based on the Subjective Grading of Tinnitus Perception, tinnitus perception diminished by 56% in patients treated with sulpiride and by 81% in patients treated with sulpiride plus hydroxyzine. Based on the visual analogical scale, tinnitus perception diminished from 7.8 to 6.3 in the patients treated with sulpiride, and from 7.8 to 5.1 in those treated with sulpiride plus hydroxyzine.
Conclusions: Sulpiride plus hydroxyzine decreases tinnitus perception. Tinnitus auditolimbic dopaminergic pathway opens wide therapeutical implications.

Treatment of tinnitus with gabapentin: a pilot study.
Otol Neurotol. 2007 Jan;28(1):11-5.
Witsell DL, Hannley MT, Stinnet S, Tucci DL
Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, Durham, North Carolina, USA. witse001@mc.duke.edu
Objective: To evaluate the effectiveness of gabapentin (Neurontin) improve the disease-specifi c quality of life in patients with moderate tinnitus.
Study design: Randomized, double blind, placebo-controlled clinical trial.
Setting: Single-center academic outpatient otolaryngology practice.
Intervetion: Gabapentin 1800 mg daily versus placebo.
Main outcome messures: The study design is a randomized, double blind placebo controlled single site trial conducted in an academic medical center. Inclusion criteria included patients between ages 18 and 70 with a complaint of nonpulsatile, subjective tinnitus, bilateral or unilateral, greater than 3 months in duration. The primary outcome measure is the Tinnitus Handicap Inventory; secondary measures include the Profile of Mood States (POMS) rating scale, subjective tinnitus severity. The null hypothesis addressed in this study is that the drug would not result in significant alleviation of the symptom of tinnitus.
Results: Seventy-six patients completed the trial; of these 52 received the drug. No significant differences were found between the two groups after 5 weeks of treatment with gabapentin.
Conclusion: There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus.

II Auditive stimulation

Cerebral activity in response to a masking sound in patients with intractable tinnitus.
(Abstract of ARO Meeting Denver, Colorado)
Mikio Suzuki1, Hideaki Kouzaki2, Minao Tamaki1, Ken Uehara1 1
University of the Ryukyus, 2Shiga University of Medical Science
Functional magnetic resonance imaging was performed in twelve patients with intractable tinnitus and normal subjects to determine the tinnitus-related regions where cerebral activity showed a positive or negative correlation to monaural masking noise stimulus. A blood oxygenation level-dependent (BOLD) signal increase was observed in the exclusive contralateral auditory cortex. There was no significant difference of the BOLD signal increase between normal subjects and patients in the conjunction analysis using random effect model. Cerebral regions that showed a BOLD signal decrease in normal subjects were the cuneus, cingulate gyrus, and paracentral lobule. In the patients group, the cerebral regions that showed a BOLD signal decrease were the postcentral gyrus, bilateral thalamus, and bilateral lingual gyrus.
A conjunction analysis using random effect model was performed to compare the decrease in BOLD signals between the tinnitus patients and controls, and revealed that the only signifi cant difference in BOLD decrement was in the bilateral thalamus. Although the relationship between tinnitus and thalamic activity is not fully understood, such thalamic activity is consistent with the fi ndings about other peripheral neural injuries.

Effectiveness of unilateral usage of the sound generator for Tinnitus Retraining Therapy.
(Abstract of ARO Meeting Denver, Colorado)
Nobumichi Maeyama1, Atsuhiko Uno1, Miki Okubo1, Yuko Takai1, Kazuyasu Baba2, Seiji Shibata2, Kouhei Kawamoto2, Hiromichi Kuriyama2, Katsumi Doi3, Masato Nishimura1
1Department of Otolaryngology, KKR Otemae Hospital, 2Osaka Kita Japan Post Hospital, 3Osaka University
Tinnitus Retraining Therapy (TRT) developed by Jastreboff and his colleagues, is a world-widely spreading treatment for tinnitus. TRT consists of directive counseling and sound therapy that typically the patient uses a sound (noise) generator to reduce awareness of tinnitus distinguished from the background noise. Generally the sound generator is recommended to use on the bilateral ears.
However, because of the reasons such as the cost, appearance and difficulty in daily conversation, we usually begin with the unilateral use, following repeated counseling and explanation of TRT itself. To assess the effectiveness of the sound therapy using the sound generator on one side, we retrospectively examined the results of 27 patients who underwent TRT at KKR Otemae Hospital and at Osaka Kita Japan Post Hospital from November 2004 to April 2006.
Two kinds of questionnaires including Tinnitus Handicap Inventory and Visual Analogue Scale were used to evaluate the results at 6 and 12 months.
Even for the patients complaining of bilateral tinnitus, TRT with unilateral sound therapy showed significant improvements at 6 months. We think that the sound therapy can begin with one sound generator on the one side, then after 6 months, the results should be evaluated. For the patient who did not show clear improvements, bilateral usage of the sound generator may be suggested.

Intervention for Restricted Dynamic Range and Reduced Sound Tolerance: Clinical Trial Update.
(Abstract of ARO Meeting Denver, Colorado)
Monica Hawley, LaGuinn Sherlock, Susan Gold1, Allyson Segar, Christine Gmitter, Justine Cannavo, Craig Formby
University of Maryland School of Medicine, Baltimore
Hyperacusis is the intolerance to sound levels that normally are judged acceptable to others. The presence of hyperacusis (diagnosed or undiagnosed) can be an important reason that some persons reject their hearing aids. Tinnitus Retraining Therapy (TRT), originally proposed for the treatment of persons with debilitating tinnitus, offers the signifi cant secondary benefi t of increased Loudness Discomfort Levels (LDLs) in many persons. TRT involves both counseling and the daily exposure to soft sound frombilateral noise generator devices (NGs). We implemented a randomized, double-blind, placebo-controlled linical trial to assess the efficacy of TRT as an intervention for reduced sound tolerance in hearingaid eligible persons with hyperacusis and/or restricted dynamic ranges. Subjects were assigned to one of four treatment groups: 1) NGs with counseling, 2) placebo NGs with counseling, 3) NGs without counseling, and 4) placebo Ngs without counseling. They were evaluated at least monthly, typically for five months or more, on a variety of audiometric tests, including LDLs, the Contour Test for Loudness for tones and speech, word recognition measured at each session's comfortable and loud levels, and on electrophysiological measures. Success for the treatment is defi ned as a tolerance increase by more than 10 dB as measured by either LDLs or Contour Test for Loudness. For the subjects in Group 1 (NGs and counseling), there was a high rate of success (5/6 subjects). A lower success rate was observed for the partial treatment options: Group 2 (placebo NGs with counseling): 1/5 subjects; Group 3 (NGs without counseling): 4/7 subjects; and Group 4 (placebo NGs without counseling): 0/2 subjects. In some subjects who initially had poor word recognition at comfortable levels, the increased tolerance allowed them to increase the level of their comfortable speech allowing a marked improvement in word recognition at comfortable levels. The interim results are very promising and support the hypothesis of this randomized controlled study that modified TRT appears to offer a new intervention for improving sound tolerance in the general hearing-impaired population, allowing persons with reduced tolerance or limited dynamic ranges to use hearing aids more effectively (Supported by NIH R01 DC04678).

Optimizing Electric Stimulation to Suppress Tinnitus.
(Abstract of ARO Meeting Denver, Colorado)
Fan-Gang Zeng1, Qing Tang1, Jeff Carroll1, Andrew Dimitrijevic1, Arnold Starr1, Leonid Litvak2, Jannine Larky3, Nikolas Blevins3
1Unversity of California Irvine, 2Advanced Bionics Corporation, 3Stanford University
Here we reported psychophysical, electrophysiological, and clinical results from a unique subject, CINH001, who received a Clarion HiRes90k cochlear implant to control debilitating tinnitus in his right ear. CINH001 had essentially normal hearing in his left ear, so that he could match both tinnitus and electric stimulation in the right ear to acoustic stimulation in the left ear. CINH001 matched his tinnitus to an acoustic stimulus of 4000-8000 Hz and at 70-90 dB SPL. The effect of electric stimulation on tinnitus was evaluated as a function of pulse rate from 25 to 5000 Hz, pulse durationfrom 10 to 500 uS per phase, electrode position from apex to base, and stimulation confi guration from monopolar to bipolar mode.
Different from previous studies showing a suppressive effect of high-rate stimulation on tinnitus, only stimuli with low rates (40-100 Hz), short pulse duration, the most apical electrode, and monopolar mode could suppress his tinnitus. Objective measures in both spontaneous and event-related evoked potentials also showed a difference related to the presence and absence of tinnitus. An innovative acoustic waveform employing a Gaussian-enveloped sinusoid and optimized programming of electric parameters allowed CINH001 to use his behind-the-ear processor to suppress tinnitus effectively at home. These results underscore the need to customize electric stimulation for tinnitus suppression and suggest that complementary stimulation, rather than masking, is the brain mechanism underlying the present surprising finding (Supported by NIH RO1 DC002267).

Tinnitus and cochlear implantation in adults - a retrospective study.
(Abstract of ARO Meeting Denver, Colorado)
Esma Idrizbegovic1, Anders Freijd2, Eva Karltorp2, Gerhard Andersson3
1Department of Audiology, Karolinska University Hospital, Stockholm, Sweden, 2Department of ENT, section for Cochlea Implant, Karolinska University Hospital, Huddinge, Sweden, 3Department of Behavioural Sciences, Linköping University, Sweden
Few studies have outlined the temporal association between cochlear implantation and tinnitus onset or changes. The aim of the study was to use validated self-report measures in a consecutive sample of cochlea implant (CI)- patients who reported tinnitus.
Methods: A total of 151 (83% response rate) responded to postal questionnaires, and of these 111 reported that they had tinnitus. Questions regarding tinnitus in relation to CI and the operation were asked. In addition, three established self report questionnaires were included measuring tinnitus handicap, hearing disability and handicap and finally a measure of anxiety and depression.
Results showed that few patients had permanently worsened tinnitus or got tinnitus following cochlear implantation. However, a fifth did report that their tinnitus was worsened. As many as 25 patients reported that their tinnitus completely disappeared when the processor was turned on and that it returned when the processor was turned off again. Only 4 patients reported that their tinnitus increased when the processor was turned on. A common response (N=31) was that tinnitus was unchanged following the CI operation. Data from established questionnaires showed relatively low levels of tinnitus handicap, moderate levels of hearing disability and handicap, and low scores on the anxiety and depression scales.
Conclusion: Significant amount of patients either experience no change in their tinnitus or a decrease. Level of tinnitus handicap overall is not marked in this population. However, tinnitus could be a significant problem in some CI patients.

III Brain stimulation

Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation.
Hum Brain Mapp. 2007 Mar;28(3):238-46.
Plewnia C, Reimold M, Najib A, Brehm B, Reischl G, Plontke SK, Gerloff C
Department of Psychiatry, Neurophysiology Section, University of Tuebingen, Tuebingen, Germany. Recent data suggest that chronic tinnitus is a "phantom auditory perception" caused by maladaptive neuroplasticity and subsequent hyperactivity in an extended neuronal network including the primary auditory cortex, higher-order association areas, and parts of the limbic system. It was suggested that attenuation of this tinnitus-associated hyperactivity may offer a rational option for lasting tinnitus reduction. Here, we tested the hypothesis that tinnitus loudness can be attenuated by low-frequency repetitive transcranial magnetic stimulation (rTMS) individually navigated to cortical areas with excessive tinnitus-related activity as assessed by [(15)O]H(2)O positron-emission tomography (PET). Nine patients with chronic tinnitus underwent this combined functional imaging and rTMS-study. Group analysis of the PET data showed tinnitus-related increases of regional cerebral blood fl ow in the left middle and inferior temporal as well as right temporoparietal cortex and posterior cingulum. Repetitive TMS was performed at 1 Hz and 120% of the motor threshold for 5, 15, and 30 min, navigated to the individual maximum of tinnitus-related cortical hyperactivity. A noncortical stimulation site with the same distance to the ear served as sham control.
Tinnitus loudness was reduced after temporoparietal, PET-guided low-frequency rTMS. This reduction, lasting up to 30 min, was dependent on the number of stimuli applied, differed from sham stimulation, and was negatively correlated with the length of the medical history of tinnitus in our patients. These data show the feasibility and effectiveness of rTMS guided by individual functional imaging to induce a lasting, dose-dependent attenuation of tinnitus. Of note, these effects were related to stimulation of cortical association areas, not primary auditory cortex, emphasizing the crucial role of higher-order sensory processing in the pathophysiology of chronic tinnitus. Hum Brain Mapp, 2007. (c) 2006 Wiley-Liss, Inc.

Effects of repetitive transcranial magnetic stimulation on chronic tinnitus. A randomised, cross over, double blind, placebo-controlled study.
J Neurol Neurosurg Psychiatry. 2007 Feb 21.
Rossi S, De Capua A, Ulivelli M, Bartalini S, Falzarano V, Filippone G, Passero S
Universita di Siena, Italy.
Background: chronic tinnitus is a disabling, almost untreatable, condition usually accompanied by psychiatric distress. In patients with complex neuropsychiatric diseases as chronic pain, with whom tinnitus shares pathophysiological similarities, placebo effects may be pronounced. Moreover, it may be difficult to distinguish actual rTMS-induced clinical benefi ts beyond placebo effects in neuropsychiatric patients.
Methods: 16 patients with chronic tinnitus underwent a randomized, double-blind, cross-over, placebo controlled trial of 1 Hz rTMS (120% of motor threshold; 1200 stimuli/day for 5 days) of the left temporoparietal region. Patients were screened for psychiatric comorbidity; additionally, anxiety and depression were monitored throughout the study. Moreover, an original placebo rTMS procedure produced the same activation of ipsilateral face muscles (a condition which may per se change tinnitus subjective rating) oft he real rTMS.
Results: responders were 8 out of 14. Two patients dropped out for transient tinnitus worsening. Active rTMS induced an overall signifi cant, but transient, improvement (35% of the basal score) of subjective tinnitus perception, that was independent either by tinnitus laterality or by mood or anxiety changes. No correlations were found between response to rTMS and tinnitus duration, initial subjective score or patients' age. When asked after the study was over, 71.4% of patients failed to identify the temporal sequence of the real or sham rTMS interventions.
Conclusions: beneficial effects of rTMS on tinnitus are independent by mood changes. Moreover, they appear in the context of an original placebo stimulation designed to more closely replicate somatic sensation of active stimulation. Due to the limited temporal duration of the clinical benefi t, these neuromodulatory effects could be mediated by transient functional changes taking place in the neural circuits underlying tinnitus processing.

Effect of vagal nerve stimulation on a rat tinnitus model.
(Abstract of ARO Meeting Denver, Colorado)
Joseph Ursick1, Dianne Durham1, Hinrich Staecker1, Phillippe Lefebvre2, Jean Schoenen3, Martin Scholsem4, Thomas Imig5
1Department of Otolaryngology Head and Neck Surgery, Kansas University Medical Center, 2Department of Otolaryngology, University of Liege, Belgium, 3Department of Neurology, University of Liege, Belgium, 4Department of Neurosurgery, University of Liege, Belgium, 5Department of Molecular and Integrative Physiology, Kansas University Medical Center
Vagal nerve stimulation (VNS) has been used to treat a variety of disorders including epilepsy and depression. Recently, VNS has been shown to decrease neuronal spontaneous activity (SA) associated with chronic facial pain in a rat model. Several animal models suggest that tinnitus may be associated with changes in SA in the dorsal cochlear nucleus (DCN), inferior colliculus, and auditory cortex. Using a rat model of noise-induced tinnitus (Durham and Imig, JCN 490:391-413, 2005), we examined the effectsof VNS on 2-deoxyglucose (2DG) uptake in the DCN of three groups of Long Evans rats. Rats were anesthetized and exposed to 15-20 kHz band pass noise at 115 dB SPL for one hour. Five days later, the VNS group (n=4) was implanted with a vagal nerve stimulator (Cyberonics, Inc.). On day 6, the stimulators were activated and on day 7, 2DG was injected. A non-VNS group (n=8) received acoustic trauma and 2DG injection after 7 days, but no VNS stimulation. A control group (n=9) received neither noise exposure nor VNS. Animals were placed in a quiet sound attenuated chamber for 45 minutes during 2DG uptake. Rats were sacrifi ced and brainstem sections were prepared for 2DG film autoradiography. Optical density (OD) measurements were used to determine 2DG uptake in the high frequency (HF) and low frequency (LF) regions of the DCN. These OD values were used to calculate asymmetry ratio (ipsi HF/LF)/(contra HF/LF). In the control group, the symmetry ratio was near one. Noise exposure decreases 2DG uptake in the high frequency region of the ipsilateral DCN. Thus, both noise trauma groups showed a decreased symmetry ratio. However, the VNS group had a symmetry ratio that was intermediate to those in control and non-VNS groups. VNS stimulation may reduce the alteration of SA caused by noise trauma and thus warrants further study as a potential tinnitus therapy (Supported by the Tinnitus Research Consortium and the Dept. of Otolaryngology Head and Neck Surgery, KUMC).

Long-Term Evaluation of Treatment of Chronic, Therapeutically Refractory Tinnitus by Neurostimulation.
Stereotact Funct Neurosurg. 2007 Jan 26;85(4):150-157.
Bartels H, Staal MJ, Holm AF, Mooij JJ, Albers FW Department of Otorhinolaryngology, University Medical Center
Groningen, Groningen, The Netherlands
Objective: Long-term evaluation of treatment of chronic, therapeutically refractory tinnitus by means of chronic electrical stimulation of the vestibulocochlear nerve.
Patients: Inclusion criteria were severe, chronic, therapeutically refractory, unilateral tinnitus and severe hearing loss at the ipsilateral site. Out of 6 patients, 4 patients were selected for long-term evaluation. Two patients were not evaluated because of premature dropout.
Material and Methods: A stimulation electrode was placed around the vestibulocochlear nerve through a retrosigmoid approach and connected to a subcutaneously positioned pulse generator via an extension cable. Follow-up was performed 3 months and 42.5 months after implantation. Three measures for treatment outcome were used. First, effect sizes were determined by means of the total Tinnitus Handicap Inventory (THI) score using Cohen's formula. Second, general and tinnitus-specifi c audiometric tests were performed in on and off conditions of the neurostimulation system. Third, recordings were noted for tinnitus severity and treatment success on a visual analogue scale.
Results: All 4 patients reported successful treatment with neurostimulation. The effect size after 3 months was 0.7, indicating an average effect, while the effect size measured during long-term follow-up was 1.75, indicating a substantial effect with major clinical implications. No changes in hearing level for both ears were measured. The neurostimulation system did not change the tinnitus pitch in any of the patients, and resulted in a minimal reduction of tinnitus loudness in only 2 patients. In all 4 patients the original tinnitus sound was replaced by another, pleasantly perceived sound. The average VAS score of perceived tinnitus severity was reduced from 8 to 3.25. The average VAS score for treatment success was 7.25. Conclusions: The long-term follow-up of neurostimulation treatment for chronic tinnitus shows promising results. Long-term results were better than those determined after a 3-month follow-up. In all patients the tinnitus was replaced by another sound, which was perceived as pleasant. Further studies are needed before accepting neurostimulation as a treatment modality for chronic, therapeutically refractory tinnitus. Copyright (c) 2007 S. Karger AG, Basel.

Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study.
J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):152-156.
Plewnia C, Reimold M, Najib A, Reischl G, Plontke SK, Gerloff C
Brain-Stimulation Laboratory, Department of Psychiatry, University of Tuebingen, Tuebingen, Germany.
christian.plewnia@uni-tuebingen.de
Background: Tinnitus has been shown to respond to modulations of cortical activity by high-frequency and low-frequency repetitive transcranial magnetic stimulation (rTMS).
Objective: To determine the tinnitus-attenuating effects of a 2-week daily regimen of rTMS, navigated to the maximum of tinnitus-related increase in regional cerebral blood fl ow.
Methods: Six patients with chronic tinnitus were enrolled in this sham-controlled crossover study and treated with 2x2 weeks of supra threshold 1 Hz rTMS (30 min) applied to the region with maximal tinnitus related increase in regional cerebral blood fl ow delineated by functional imaging with [15O]H2O positron emission tomography and a control area. Tinnitus-related distress was assessed before and after each treatment and 2 weeks after the end of the 4-week course of stimulation using a validated tinnitus questionnaire. Additional self-assessment scores of tinnitus change, loudness and annoyance were obtained.
Results: In five of six patients, rTMS induced greater reduction of the tinnitus questionnaire score than sham stimulation. In two patients, all parameters measured (tinnitus change score, tinnitus loudness, tinnitus annoyance) showed unequivocal improvement. At the group level, the degree of response in the tinnitus questionnaire score was correlated with tinnitus-associated activation of the anterior cingulated cortex. Two weeks after the fi nal stimulation, tinnitus had returned to baseline in all patients but one.
Conclusion: Tinnitus can be attenuated by low-frequency rTMS navigated to each person's maximum tinnitus-related cortical hyperactivity. The effects are only moderate; interindividual responsiveness varies and the attenuation seems to wear off within 2 weeks after the last stimulation session. Notably, tinnitus relatedanterior cingulate cortex activation seems to predict the response to rTMS treatment.

Repetitive Transcranial Magnetic Stimulation for Tinnitus: A Pilot Study.
Laryngoscope. 2007 Mar;117(3):529-534.
Smith JA1, Mennemeier M2, Bartel T3, Chelette KC2, Kimbrell T4, Triggs W5, Dornhoffer JL1, 2
1From the Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.;2the Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.; 3the Department of Radiology, Division of Nuclear Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.; 4the Department of Psychiatry, University of Arkansas for Medical Sciences and Mental Health Service, Central Arkansas Veterans Healthcare System (CAVHS), North Little Rock, Arkansas,U.S.A.;5The Department of Neurology, University of Florida, Gainesville, Florida, U.S.A.
Objectives/Hypotheses: Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate tinnitus perception, presumably by inhibiting cortical activity associated with tinnitus. We conducted a pilot study to assess effectiveness of neuronavigated rTMS and its effects on attentional deficits and cortical asymmetry in four patients with chronic tinnitus using objective and subjective measures and employing an optimization technique refi ned in our laboratory.
Study design: Randomized, placebo-controlled (sham stimulation) crossover study. Methods: Patients received 5 consecutive days of active, low-frequency rTMS or sham treatment (using a 45-degree coil-tilt method) before crossing over. Subjective tinnitus was assessed at baseline, after each treatment, and 4 weeks later. Positron emission tomography/computed tomography (PET/CT) scans were obtained at baseline and immediately after active treatment to examine change in cortical asymmetry. Attentional vigilance was assessed at baseline and after each treatment using a simple reaction time test.
Results: All patients had a response to active (but not sham) rTMS, as indicated by their best tinnitus ratings; however, tinnitus returned in all patients by 4 weeks after active treatment. All patients had reduced cortical activity visualized on PET immediately after active rTMS. Mean reaction time improved (P <.05) after active but not sham rTMS.
Conclusions: rTMS is a promising treatment modality that can transiently diminish tinnitus in some individuals,but further trials are needed to determine the optimal techniques required to achieve a lasting response. It is unclear whether the improved reaction times were caused by tinnitus reduction or a general effect of rTMS. PET/CT scans immediately after treatment suggest that improvement may be related to reduction of cortical asymmetry associated with tinnitus.

Transcranial magnetic stimulation for the treatment of auditory phantom perceptions (tinnitus) - a randomized placebo controlled study.
(Abstract of ARO Meeting Denver, Colorado)
Tobias Kleinjung1, Berthold Langguth2, Peter Eichhammer2, Michael Landgrebe2, Philipp Sand2, Juergen Strutz1, Goeran Hajak2
1University of Regensburg, Department of Otorhinolaryngology, 2University of Regensburg, Department of Psychiatry
Introduction: Repetitive transcranial magnetic stimulation (rTMS) represents a minimal invasive tool for focal brain stimulation. Patients suffering from auditory phantom perceptions (tinnitus) demonstrated focal brain activation within the auditory cortex. Neuronavigated low frequency transcranial magnetic stimulation of the area of increased activity cortex was able to reduce tinnitus perception in first studies.
Methods: Patients suffering from chronic tinnitus underwent a FDG- PET study (positron emission tomography with [18F]deoxyglucose) to detect areas of increased metabolic activity in the cortex. Fusioning of the individual PET scans with structural MRI-scans (T1, MPRAGE) revealed an increased metabolic activation in the primary auditory cortex as target point for rTMS. The exact position of the figure 8-shaped magnetic coil in relation to the target was monitored with a neuronavigational system. The rTMS (110%motor threshold; 1 Hz; 2000 stimuli/ day over 10 days) was performed in a placebo controlled design. For sham stimulation a specific sham-coil system was used. Treatment outcome was assessed over a 3 months period with a tinnitus questionnaire (Goebel and Hiller).
Results: Up to now 60 patients have been included in the trial. In a majority of patients we could localize an increased metabolic activation in the upper dorsal part of the left superior temporal gyrus corresponding to areas of the auditory cortex. Preliminary results indicate that active rTMS results in a significantimprovement of tinnitus perception compared to sham rTMS. Treatment effects lasted up to 3 months insome patients.
Conclusion: Neuronavigated low-frequency rTMS seems to represent a promising strategy for the treatment of chronic tinnitus.

IV Behavioral therapy

Cognitive behavioural therapy for tinnitus.
Cochrane Database Syst Rev. 2007 Jan 24;(1):CD005233.
Martinez Devesa P, Waddell A, Perera R, Theodoulou M
Background: Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation (not usually audible to anyone else). At present no specifi c therapy for tinnitus is acknowledged to be satisfactory in all patients.Cognitive behavioural therapy (CBT) uses relaxation, cognitive restructuring of the thoughts and exposure to exacerbating situations in order to promote habituation and may benefi t tinnitus patients, as may the treatment of associated psychological conditions.
Objectives: To assess whether cognitive behavioural therapy is effective in the management of patients suffering from tinnitus.
Search strategy: Our search included the Cochrane ENT Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2006), MEDLINE and EMBASE. The last search date was June 2006.
Selection criteria: Randomised controlled trials in which patients with unilateral or bilateral tinnitus as main symptom received cognitive behavioural treatment.
Data collection and analysis: One review author (PMD) assessed every report identified by the search strategy. The four review authors assessed the methodological quality, applied inclusion/exclusion criteria and extracted data.
Main results: Six trials comprising 285 participants were included.1. Primary outcome: subjective tinnitus loudness CBT compared to a waiting list control group: we found no significant difference (Standardised Mean Difference (SMD) 0.06 (95% CI -0.25 to 0.37)).CBT compared to another intervention (Yoga, Education, Minimal Contact - Education and Education): we found no significant difference (SMD 0.1 (95% CI -0.22 to 0.42)).2. Secondary outcome ) Depression CBT compared to a waiting list control group: we found no significant difference in either group (SMD 0.29 (95%CI -0.04 to 0.63)).CBT compared to another intervention (Yoga, Education and Minimal Contact - Education): we found no significant difference (SMD 0.01 (95% CI -0.43 to 0.45)).b) Quality of lifeCBT compared to a waiting list control group: we found a significant difference in favour of CBT versus the waiting list group (SMD 0.7 (95% CI 0.33 to 1.08)).CBT compared to another intervention (Education, Minimal Contact - Education and Education): we also found a significant difference between CBT and the other intervention control group (SMD 0.64 (95% CI 0.29 to 1.00)).There were no adverse/side effects reported in any trial.
Authors' conclusions: We did not find a significant difference in the subjective loudness of tinnitus, or in the associated depression. However we found a significant improvement in the quality of life (decrease of global tinnitus severity) of the participants, thus suggesting that cognitive behavioural therapy has an effect on the qualitative aspects of tinnitus and contributes positively to the management of tinnitus.

Ericksonian hypnosis in tinnitus therapy: effects of a 28-day inpatient multimodal treatment concept measured by Tinnitus-Questionnaire and Health Survey SF-36.
Eur Arch Otorhinolaryngol. 2007 Jan 6.
Ross UH, Lange O, Unterrainer J, Laszig R
Practice for Otorhinolaryngology and Psychotherapy, Luisenstrasse 6, 79098, Freiburg, Germany, Dr- Ross@web.de.
For the fi rst time, the therapeutic effects on subacute and chronic tinnitus of an inpatient multimodal treatment concept based on principles of Ericksonian hypnosis (EH) were examined by standardized criteria of the Tinnitus Questionnaire (TQ) and Health Survey (SF-36) within a controlled prospective, longitudinal study. A total of 393 patients were treated within an inpatient closed-group 28-day-setting based on a resource-oriented, hypnotherapeutic concept. The severity of tinnitus was assessed by TQ at times of admission, discharge and also at a 6- and 12-month follow-up. Health-related quality of life was evaluated before and after therapy using the SF-36. After therapy, a decrease in TQ score was seen in 90.5% of the patients with subacute tinnitus and in 88,3% of those with chronic tinnitus. Assessment of the TQ score at the end of therapy revealed highly signifi cant improvements of 15.9/14.1 points in mean. Effect sizes in the treatment groups (0.94/0.80) were superior to those in the waiting-list controls (0.14/0.23). The TQ score remained stable in the follow-up controls. Signifi cant improvement in health related quality of life has been observed within the treatment groups depending on initial level of tinnitus serverity I-IV according to TQ. Using a multimodal treatment concept with emphasis on resource-activating approaches of EH the annoyance of tinnitus can be signifi cantly reduced while health-related quality of life is enhanced within a comparatively short treatment period of 28 days.

V Diagnostics

Acoustic shock.
J Laryngol Otol. 2007 Feb 19;:1-5.
McFerran DJ, Baguley DM Department of Otolaryngology and Head and Neck Surgery, Essex County Hospital, Colchester, UK.
Acoustic shock is a recently recognised clinical entity: following an abrupt, intense and unanticipated acoustic stimulus, usually delivered by a telephone handset or headset, some individuals report a symptom cluster that includes otalgia, altered hearing, aural fullness, imbalance, tinnitus, dislike or even fear of loud noises, and anxiety and/or depression. Symptoms start shortly after the triggering acoustic incident and can be short-lived or can last for a considerable time. If persistent, the condition can lead to significant disability. Proposed mechanisms include involvement of the tensor tympani muscle, hyperexcitability of central auditory pathways, and a precursive state of raised anxiety or arousal. A formal treatment programme has not yet been proposed, but the potential utility of modern therapeutic techniques for tinnitus and hyperacusis are considered. Given the large number of UK residents working in telephone call centres, this condition is of considerable clinical importance.

Anxiety and Depressive Symptoms in Tinnitus Patients.
(Abstract of ARO Meeting Denver, Colorado)
Andrea Crocetti1, Stella Forti1,2 1Fondazione Ascolta e Vivi, 2Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena
Our clinical knowledge of tinnitus is based on treatment of over 1500 tinnitus patients. We have observed a correlation between tinnitus and symptoms of anxiety and depression which often affect daily life. Patients report that an increasing level of anxiety also exacerbates tinnitus symptoms. This can be explained neurophysiologically by the effect of the limbic system, cortex and peripheral neuropathways in tinnitus. The aim of this study is to investigate any correlation between tinnitus and anxiety and depressive symptoms.
Materials and methods: The assessment is composed of: Visual Analogical Scales (VAS) for the evaluation of tinnitus induced problems; Tinnitus Handicap Inventory (THI); State and Trait Anxiety Inventory-Y (STAI S-T); Beck Depression Inventory (BDI). These instruments were chosen based on their psychometric properties, time of administration and validity in many languages; the sample consists of 67 patients.
Results: Correlation between anxiety symptoms and THI score is signifi cant (p<0,01); the same significance was found between depressive symptoms and THI as well as between STAI and BDI. Significant correlation was also found between these questionnaires and the intensity of tinnitus, annoyance and effect on life evaluated by the VAS scale. 23% of the sample had severe tinnitus. Mean anxiety was around the 65th percentile; 35% having an anxiety disorder. 12% of the total sample shows a depressive pathology. 11% of the sample have both anxiety and depression. An inverse correlation between STAI and BDI scores and the duration of tinnitus was observed.
Conclusions: Although about 1/3 of patients are suspected of suffering from anxiety, a pathological level of anxiety and depression was found in only about 10% of the sample. The THI questionnaire is a good predictor for patients with higher levels of depression and anxiety.

Cholesterol granuloma surrounding the endolymphatic sac.
Auris Nasus Larynx. 2007 Mar;34(1):95-100.
Kanzaki S, Araki Y, Okamoto Y, Kurita A, Ogawa K
Department of Otorhinolaryngology, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan. skan@sc.itc.keio.ac.jp
We report a unique case of cholesterol granuloma (CG) surrounding the endolymphatic sac (ES). A 49-year-old man presented with the left side of sensorineural hearing loss, tinnitus, and vertigo. Magnetic resonance and computed tomography imaging revealed a CG surrounding the left ES. The patient initially underwent left transmastoid surgical resection of the tumor. At the time of surgery, brown fluid was aspirated from the tumor, but no other tumors were found. Histopathological examination revealed that the tumor contained cholesterol crystals, confi rming the diagnosis of CG. At his 12-month postoperative follow-up, there was no evidence of recurrence. We discuss the radiology, pathology, and surgical removalof CGs surrounding ES.

Clinical characterization and genetic analysis of a large Brazilian family with Familial Migrainous Vertigo.
(Abstract of ARO Meeting Denver, Colorado)
Fayez Bahmad Jr, M.D.1,2,4,5,6,7 Saumil N. Merchant, MD1,5,6, Roberta L. Bezerra, M.D., PhD2,4, Jonathan G. Seidman, Ph.D3,7, Carlos A Oliveira, M.D., Ph.D.2,4
1Massachusetts Eye & Ear Infirmary, 2Brasilia University Hospital, 3Harvard Medical School, 4Departmentof Otolaryngology, Brasília University Medical School, Brasília, D.F., Brazil, 5Department of Otolaryngology, Massachussetts Eye & Ear Infi rmary, Boston, MA, USA, 6Department of Otology, Massachussetts Eye & Ear Infi rmary, Harvard Medical School, Boston, MA, USA, 7Seidman Laboratory, Department ofGenetics, Harvard Medical School, Boston, MA, USA.
Introduction: Since 1995, we have been studying a large Brazilian family whose members are affectedwith migrainous vertigo syndrome.
Objectives: The aim of this study is to describe clinical features and the natural history of this symptom complex. We also wish to characterize the genetic basis for this condition in the family.
Methods: A six generation Caucasian family originating from the center of Brazil was followed over ten years and data was collected from 146 members. Clinical data collected has included detailed case histories, otolaryngological and neurological examinations, audiometric evaluation, vestibular testing and imaging studies. Serial clinic and audiometric evaluations were done. We have also undertaken a genome wide linkage analysis in 64 family members and subsequent fi ne mapping using microsatellite markers.
Results: Our study reveals an autosomal dominant pattern of transmission with incomplete penetrance of the gene and variable expression. Of the 146 members, 32 suffer from migraine with aura. Of these 32 individuals, 10 also suffer from episodic vertigo, tinnitus and/or aural fullness. Audiometric evaluation did not show classic low tone fl uctuating sensorineural hearing loss (SNHL). Imaging studies were normal. In this family, migraine preceded the neuro-otological symptoms by 15-20 years on average. Overall, migraine symptoms decreased with time, while the vertigo symptoms had a tendency to get worse. Genetic analysis revealed an area with high lod scores in chromosome 5. Therefore, the genetic locus for this symptom complex in this family appears to be on chromosome 5. Studies are ongoing to investigate candidate genes in this locus.

A clinical study of the efferent auditory system in patients with normal hearing who have acute tinnitus.
Otol Neurotol. 2007 Feb;28(2):185-190.
Riga M, Papadas T, Werner JA, Dalchow CV,
Department of Otorhinolaryngology, Head and Neck Surgery, University of Patras, Greece.
Objective: Etiological diagnosis and treatment of tinnitus still remain challenging in clinical practice. The aim of this study was to determine the potential contribution of a defective cochlear efferent innervation to the onset of tinnitus in patients with normal hearing.
Study design: Prospective randomized controlled study.
Setting: Otorhinolaryngology department of a general hospital.
Patients: The patient group consisted of 18 normal-hearing adults (7 men, 11 women) with acute tinnitus(bilateral in 3 patients).
Interventions: Tympanogram, stapedial muscle reflex, pure tone audiometry, tinnitus pitch matching, spontaneous otoacoustic emissions, and distortion product otoacoustic emissions (DPOAEs) in the absence and presence of contralateral suppression by white noise.
Main outcome messure: DPOAEs suppression amplitudes recorded from tinnitus and nontinnitus ears of the patients' group were compared with each other and with a control group.
RESULTS: The contralateral application of white noise induced the enhancement of DPOAE amplitudes in some patients. The suppression of DPOAE amplitudes by contralateral white noise did not reach statistically significant levels in either ear (with or without tinnitus). On the contrary, under the same conditions, our control group demonstrated statistically significant reduction of DPOAE amplitudes at all frequencies.
Conclusion: Patients with normal hearing acuity who have acute tinnitus seem to have a less effective functioning of the cochlear efferent system because the application of contralateral noise enhanced the DPOAEs or suppressed them less intensely than it did in a control group. Further studies may establish the clinical applications for the diagnosis of changes in efferent function, in the subjective evaluation, patient etiological grouping, treatment, or prognosis of tinnitus.

The Epidemiology of Meniere's Disease and the Problems of Diagnosis.
(Abstract of ARO Meeting Denver, Colorado) George Gates University of Washington MD is a common disorder of unknown etiology that causes episodic vertigo with hearing loss, tinnitus, and ear fullness. Stress is a commonly cited co-factor in the pathogenesis of MD. MD affects both genders equally and is most common in 40-55 year olds. Some women have symptoms in relation to their menstrual cycle; whether this is hormonal or a refl ection of stress is unclear. The overall prevalence of MD is estimated from 17/100,000 population in the U.S. To 46/100,000 in Sweden. The clinical course is variable and unpredictable. About 70% of patients respond to conservative treatment, such as low salt diet, diuretics and symptom suppressants, however 30% get progressively worse and often require surgical therapy. Although the long-term treatment results are acceptable, selection of cases for medical and surgical therapy varies widely.

Imaging of pulsatile tinnitus: a review of 74 patients.
Clin Imaging. 2007 Mar-Apr;31(2):102-108.
Sonmez G, Basekim CC, Ozturk E, Gungor A, Kizilkaya E
Department of Radiology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey.
Objective: Our aim was to assess the effectiveness of imaging modalities in detecting the underlying pathologies in patients with pulsatile tinnitus.
Materials and methods: Seventy-four patients with pulsatile tinnitus were radiologically evaluated. All patients except two are evaluated on a thin-section bone algorithm computed tomography scan covering the temporal bone and skull base, 14 patients with or without contrast-enhanced brain computed tomography, 7 patients with magnetic resonance imaging and magnetic resonance angiography, 5 patients with digital subtraction angiography, and 12 patients with Doppler ultrasonography.
Results: The underlying pathology of tinnitus was detected in 50 patients (67.6%), and 24 patients were normal with radiologic studies. The most common cause was high jugular bulbus (21%) followed by atherosclerosis, dehiscent jugular bulbus, aneurysm of internal carotid artery, dural arteriovenous fistula, aberrant internal carotid artery, jugular diverticulum, and glomus tumor.
Conclusion: It was concluded that radiologic imaging methods are effective in detecting the underlying pathology of pulsatile tinnitus.

Post-traumatic pulsatile tinnitus: the hallmark of a direct carotico-cavernous fistula.
L Laryngol Otol. 2007 Feb 13;:1-5.
Lerut B, De Vuyst C, Ghekiere J, Vanopdenbosch L, Kuhweide R
Department of Otolaryngology, Az St Jan Hospital, Bruges, Belgium.
Following trauma to her right frontal region, a 68-year-old woman suffered bilateral, benign, paroxysmal, positional vertigo and a left-sided, longitudinal petrosal bone fracture, with secondary facial palsy and ossicular luxation. From the onset, the patient complained of pulsatile, left-sided tinnitus. After eight weeks, she developed left-sided ocular symptoms, progressing from conjunctival hyperaemia and orbital oedema to an abducens nerve palsy, and ultimately to heart failure.The case and the final diagnosis of carotico-cavernous fi stula are discussed. Guidelines are proposed for a diagnostic approach to pulsatile tinnitus and for the optimal management of patients presenting with pulsatile tinnitus associated with ocular symptoms.

Perceptual Components of Tinnitus Severity
(Abstract of ARO Meeting Denver, Colorado)
Mary Meikle1, James Henry2, Susan Griest1, Barbara Stewart1
1Oregon Health & Science University, 2Portland VA Medical Center, Portland,
OR Most existing questionnaires for assessing the severity and negative impact of tinnitus tend to emphasize functional or emotional effects of tinnitus. While such measures are important for diagnostic purposes and as outcome measures, they require time periods of several days to several weeks or longer for observation of meaningful changes following treatment.
More rapid evaluation of treatment outcomes can be obtained using patients' reports of the perceptual characteristics of tinnitus such as its loudness, salience, unpleasantness, intrusiveness, and the percentage of time the tinnitus sensations are perceived. However, the extent to which such perceptual attributes of tinnitus are appropriate indicators of the clinical severity of tinnitus has received relatively little systematic attention. To maximize measurement sensitivity, we designed a 43-item questionnaire to quantify patients' responses concerning functional, emotional and perceptual aspects of tinnitus, using a 0-10 point response scale for each question. A total of 327 subjects with varying levels of tinnitus, recruited from a diverse group of patients attending clinics in three locations (Oregon, Ohio, Florida), responded to the questionnaires before and after receiving treatment. As expected, the perceptual attributes listed above were positively related to global measures of tinnitus distress, including (1) a Visual Analog Scale and (2) the question "How much of a problem is your tinnitus?" (response levels: 0=Not a problem; 1=Small problem; 2=Moderate problem; 3=Big problem; 4=Very big problem). Effect sizes for the perceptual measures (computed for subjects reporting treatment benefi t) ranged from 0.49- 1.50. Additional data will be presented concerning the ability of perceptual measures to serve as reliable, sensitive outcome measures for studies that require rapid evaluation of tinnitus treatments having immediate effects, such as stimulation with electrical, magnetic, or acoustic stimuli.

Relationships among speech perception, self-rated tinnitus loudness and disability in tinnitus patients with normal pure-tone thresholds of hearing.
ORL J Otorhinolaryngol Relat Spec. 2007;69(1):25-9.
Huang CY, Lee HH, Chung KC, Chen HC, Shen YJ, Wu JL
Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan, ROC.
Exactly how speech perception and tinnitus perception are related remains unclear. This study investigated how tinnitus alone affects speech perception and the relationship between speech perception, tinnitus loudness, and tinnitus disability. The Mandarin Speech Perception in Noise Test (MSPIN), Tinnitus Loudness Scaling (TLS), and Tinnitus Handicap Inventory (THI) were utilized to assess 20 tinnitus patients with normal hearing. The tinnitus group had a signifi cantly lower MSPIN score than the control group (p < 0.01). TLS and THI scores were strongly correlated (r(2): 0.534 approximately 0.627, p < 0.05). Correlations between MSPIN and TLS or THI scores were not signifi cant. Tinnitus loudness correlated well with tinnitus-related disability. Neither tinnitus loudness nor disability was strongly correlated with speech perception. In noisy environments, tinnitus sufferers had signifi cantly poorer ability to recognizespeech than control subjects. Copyright (c) 2007 S. Karger AG, Basel

Sofi a profi le plot: a new graphical approach to present the changes of hearing thresholds with time.
Adv Otorhinolaryngol. 2007;65:127-131.
Lolov S, Edrev G
Department of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofi a, Bulgaria. dr_lolov@yahoo.com
After pure-tone audiometry, we have several sequences of threshold values. Usually, a multiple-line plot is used to present and compare data between measurements by overlaying them in a single graph. Calculation of air-bone gap and pure-tone average is widely accepted as an approach to simplify statistical handling of these data. The aim of this report was to introduce the Sofi a profi le plot using as examples different otosclerotic cases. This plot provides a simple way to visually present several pre- and postoperative hearing thresholds. Individual data points (pure-tone average and some other thresholds) are presented by marks in two-dimensional space. The vertical axis represents the time line and starts with the first threshold evaluation. The horizontal scale is used to mark hearing levels in decibels -- the right ear on the left of the vertical axis and the left ear on the right. The Sofi a profi le plot was developed especially for otosclerotic patients and permits the unambiguous marking of the onset of any individual unilateral or bilateral event (e.g. operation, revision, tinnitus) and thus to visually inspect its impact on hearing levels.

Susceptibility to Tinnitus Revealed at 2 kHz Range by Bilateral Lower DPOAEs in Normal Hearing Subjects with Noise Exposure.
Audiol Neurootol. 2007 Jan 25;12(3):137-144.
Job A, Raynal M. Kossowski M
Centre de Recherches du Service de Sante des Armees (CRSSA), La Tronche, France.
We investigated potential markers of susceptibility to tinnitus in a group of normal hearing young pilots aged 25-35 years and with 8 +/- 5 years of aircraft noise exposure. 316 pilots were interviewed about their tinnitus status and were tested for hearing thresholds (audiograms) and distortion products otoacoustic emissions (DPOAE-grams). There was no subject with permanent tinnitus. 23% reported having occasionally perceived tinnitus after flight missions and 77% reported never having experienced tinnitus after flight missions. General discomfort in the ears to noise was higher in the occasional tinnitus group (15 vs. 6%). The major finding was that difference of susceptibility to tinnitus in normal hearing subjects exposed to noise on a daily basis seemed to be clearly related to lower DPOAEs, bilaterally, in the 1500- to 2800-kHz range. However, no difference could be observed between groups on audiograms at the 2-kHz frequency range. This study provided evidence of outer hair cell dysfunctions in normal hearing subjects exposed to noise and susceptible to tinnitus. Hypersensitivity to noise and decreased DPOAEs in a non-noise-specifi c frequency range support the idea of another alteration mechanism than noise itself.
This point was discussed in the light of recent publications. Copyright (c) 2007 S. Karger AG, Basel.

[Validation of the German-Version Tinnitus Handicap Inventory (THI).].
Psychiatr Prax. 2007 Jan;34(S1):140-142. [Article in German].
Kleinjung T, Fischer B, Langguth B, Sand PG, Hajak G, Dvorakova J, Eichhammer P
Klinik fur Hals-Nasen-Ohren-Heilkunde der Universität Regensburg
Objective: Tinnitus counts among the most debilitating auditory handicaps and is often complicated by insomnia, concentration diffi culties, depression, frustration and irritability. To facilitate the grading of symptoms, we validated a German-version Tinnitus Handicap Inventory (THI) in 74 subjects suffering from chronic tinnitus.
Methods: Outcome validity was assessed using the Tinnitus Questionnaire (TQ, German adaptation by Goebel u. Hiller [1998]). Construct validity was assessed using the Beck Depression Inventory (BDI).
Results: The German THI featured excellent internal consistency (total score Cronbach's alpha = 0.93). Factor analysis disclosed three THI subscales as proposed earlier by Newman et al. [1996]. Intercorrelations were strong both between the THI and the TQ ( R = 0.70), and between the THI and the BDI ( R = 0.64).
Conclusions: The German-version THI qualifies as a rapid and statistically robust tool for grading the impact of tinnitus on daily living. With regard to depressive symptomatology, sensitivity of the THI was comparable to that of the TQ.

VI Imaging

Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation.
Hum Brain Mapp. 2007 Mar;28(3):238-246.
Plewnia C, Reimold M, Najib A, Brehm B, Reischl G, Plontke SK, Gerloff C
Department of Psychiatry, Neurophysiology Section, University of Tuebingen, Tuebingen, Germany
Recent data suggest that chronic tinnitus is a "phantom auditory perception" caused by maladaptive neuroplasticity and subsequent hyperactivity in an extended neuronal network including the primary auditory cortex, higher-order association areas, and parts of the limbic system. It was suggested that attenuation of this tinnitus-associated hyperactivity may offer a rational option for lasting tinnitus reduction. Here, we tested the hypothesis that tinnitus loudness can be attenuated by low-frequency repetitive transcranial magnetic stimulation (rTMS) individually navigated to cortical areas with excessive tinnitus-related activity as assessed by [(15)O]H(2)O positron-emission tomography (PET). Nine patients with chronic tinnitus underwent this combined functional imaging and rTMS-study. Group analysis of the PET data showed tinnitus-related increases of regional cerebral blood fl ow in the left middle and inferior temporal as well as right temporoparietal cortex and posterior cingulum. Repetitive TMS was performed at 1 Hz and 120% of the motor threshold for 5, 15, and 30 min, navigated to the individual maximum of tinnitus-related corticalhyperactivity. A noncortical stimulation site with the same distance to the ear served as sham control.
Tinnitus loudness was reduced after temporoparietal, PET-guided low-frequency rTMS. This reduction, lasting up to 30 min, was dependent on the number of stimuli applied, differed from sham stimulation, and was negatively correlated with the length of the medical history of tinnitus in our patients. These data show the feasibility and effectiveness of rTMS guided by individual functional imaging to induce a lasting, dose-dependent attenuation of tinnitus. Of note, these effects were related to stimulation of cortical association areas, not primary auditory cortex, emphasizing the crucial role of higher-order sensory processing in the pathophysiology of chronic tinnitus. Hum Brain Mapp, 2007. (c) 2006 Wiley-Liss, Inc.

Effects of tinnitus laterality on brain activity - a positron emisson tomography study.
(Abstract of ARO Meeting Denver, Colorado)
Berthold Langguth1, Tobias Kleinjung2, Juergen Strutz2, Goeran Hajak1, Peter Eichhammer1
1Department of Psychiatry, University of Regensburg, 2Department of Otorhinolaryngology, University of Regensburg
Modern brain imaging methods including functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) afford unprecedented opportunities for the in vivo study of central auditory system function. With the advent of these mapping techniques new insights into the etiology of chronic tinnitus could be gained. Particularly, PET studies have contributed to a paradigm shift, demonstrating that the actual generator of chronic tinnitus is central in most cases. In detail, using [18F] deoxyglucose (FDG) as a radiotracer our group could replicate and confi rm previous fi ndings pointing to a significantly increased metabolic activity in the left primary auditory cortex (PAC, Brodmann area 41) in patients suffering from permanent tinnitus complaints. These imaging results have also build the rationale basis to use low- frequency PET-guided repetitive transcranial magnetic stimulation as a causally orientated treatment option for tinnitus.
This fi nding of unilaterally increased metabolic activity in the left auditory cortex independently of tinnitus laterality contrasts with fi ndings in animal models of tinnitus where increased activity has been detected in the auditory cortex contralateral to the tinnitus side.
To further investigate the effect of tinnitus laterality on brain activation patterns we compared FDG PET data from patients with different tinnitus laterality (unilateral left, unilateral right, bilateral predominantly right, bilateral).
Results have shown that differences in tinnitus laterality are refl ected by different metabolic activity patterns in distinct nonauditory cortical regions. These results may help to develop new treatment targets for chronic tinnitus and to further individualize treatment strategies.

Metabolic activation of auditory cortex and inferior colliculi during salicylate-induced tinnitus in rats: A microPET imaging study.
(Abstract of ARO Meeting Denver, Colorado)
Asit Paul, Edward Lobarinas, John Luisi, Richard Simmons, Hani Nabi, Richard Salvi
University at Buffalo
The purpose of this study is to investigate the metabolic activities in central auditory structures in vivo during salicylateinduced tinnitus in rats. The behavioral paradigm, schedule induced polydipsia-avoidance conditioning (SIPAC), was fi rst used to determine if tinnitus was present in rats treated with a high dose of salicylate. Following verifi cation of salicylate induced tinnitus, a dedicated, high resolution animal positron emission tomography system (microPET Focus 120) was used to image the changes in brain metabolic activities associated with a high-dose of salicylate (250 mg/kg, i.p). In both the baseline and salicylate condition, rats were placed in a sound attenuating cubicle for 60 min after the injection of a radiolabeled glucose analog, F-18 labeled fl uorodeoxyglucose (FDG, ~74 MBq, i.p). Thereafter, microPET scans of the rat brains were performed for 60 min in the prone position under isofl urane gas anesthesia.
The frontal pole was considered as reference (control) area; FDG counts in frontal pole were expressed as a fraction of injected FDG dose per unit volume. Counts ratio between central auditory structures (auditory cortices, thalami and inferior colliculi) and frontal pole was used to compare between baseline and post-salicylate metabolic activity. The results show that the frontal pole FDG activity did not change between baseline and the post-salicylate condition, suggesting it as a metabolically inert area during tinnitus. During salicylate induced tinnitus, inferior colliculi (P=0.03) and auditory cortices (P=0.003) showed significant increase in FDG activities, whereas there was no signifi cant difference in thalamic activity (P=0.07) from the pre-salicylate, baseline state. Our study shows increased metabolic activity consistent with neuronal activation in inferior colliculi and auditory cortices during salicylate-induced tinnitus in rats (Supported by Tinnitus Research Consortium).

The neural code of auditory phantom perception.
J Neurosci. 2007 Feb 7;27(6):1479-1484.
Weisz N, Muller S, Schlee W, Dohrmann K, Hartmann T, Elbert T
Department of Psychology, University of Konstanz, D-78464 Konstanz, Germany.
weisz@lyon.inserm.fr
Tinnitus is defined by an auditory perception in the absence of an external source of sound. This condition provides the distinctive possibility of extracting neural coding of perceptual representation. Previously,we had established that tinnitus is characterized by enhanced magnetic slow-wave activity (approximately 4 Hz) in perisylvian or putatively auditory regions. Because of works linking high-frequency oscillations to conscious sensory perception and positive symptoms in a variety of disorders, we examined gamma band activity during brief periods of marked enhancement of slow-wave activity. These periods were extracted from 5 min of resting spontaneous magnetoencephalography activity in 26 tinnitus and 21 control subjects. Results revealed the following, particularly within a frequency range of 50-60 Hz: (1) Both groups showed significant increases in gamma band activity after onset of slow waves. (2) Gamma is more prominent in tinnitus subjects than in controls. (3) Activity at approximately 55 Hz determines the laterality of the tinnitus perception. Based on present and previous results, we have concluded that cochlear damage, or similar types of deafferentation from peripheral input, triggers reorganization in thecentral auditory system. This produces permanent alterations in the ongoing oscillatory dynamics at the higher layers of the auditory hierarchical stream. The change results in enhanced slow-wave activity refl ecting altered corticothalamic and corticolimbic interplay. Such enhancement facilitates and sustainsgamma activity as a neural code of phantom perception, in this case auditory.

VII Pathophysiology

Acoustic Trauma Induces Long-Term Temporal Correlations in DCN.
(Abstract of ARO Meeting Denver, Colorado)
Benjamin Letham, Wei-Li D. Ma, Shanqing Cai, Eric D. Young
Center for Hearing and Balance, Department of Biomedical Engineering, Johns Hopkins University Changes to the functional properties of the dorsal cochlear nucleus (DCN) that follow acoustic trauma are not well understood. Past studies (e.g. Kaltenbach et al.) have reported an increase in mean spontaneous firing rates following acoustic trauma. However, recent work from our lab in DCN principal cells has found no change in mean spontaneous fi ring rate. This fi nding has led us to study temporal patterns in DCN spontaneous activity that may change independent of the mean rate. One pattern of specific interest is long-range dependence (LRD). LRD is an effect of fractal rate fluctuations, where rate fluctuations have weak correlations on the scale of minutes.
Cats were acoustically traumatized by exposure to 10kHz noise at 107dB SPL for four hours. Compound action potentials showed a >60dB threshold shift at and above 10kHz. Ten minutes of spontaneous activity were recorded from isolated single DCN units in these deaf cats as well as a group of normal hearing cats. LRD can be quantifi ed by computing the Fano factor for a range of counting times. The Fano factor has a power-law dependence on counting time, and the exponent of the power-law is called the fractal dimension. This dimension is a measure of the spike count variance and LRD. The average fractal dimension of the 10kHz-exposed DCN units is signifi cantly higher than that of normal DCN units.
Surprisingly, there is no correlation between higher fractal dimension and the degree of threshold shift (or spontaneous activity). The increased fractal dimension implies that neurons in exposed cats have more long-term correlations and higher spike count variance. Increased spike count variance could contribute to tinnitus by providing a fl uctuating rate signal that would be interpreted as resulting from a fluctuating sound. (Supported by NIH grant DC00109 and the Tinnitus Consortium).

Alterations In Spontaneous Discharge Rates Of Single Units In The Dorsal Cochlear Nucleus Induced By Intense Sound Exposure.
(Abstract of ARO Meeting Denver, Colorado)
Paul Finlayson, James Kaltenbach
Wayne State University
Hyperactivity in the dorsal cochlear nucleus (DCN), characterized by increases in spontaneous activity, has been implicated as a possible factor contributing to tinnitus following noise exposure. Evidence for the phenomenon of noise induced hyperactivity in the DCN has been obtained mostly using methods that examine activity of neural clusters (multiunit recordings) or populations of neurons (c-fos, 2-deoxyglucose), an exception being a study by Brozoski et al., 2002, demonstrating noise-induced increases in single unit spontaneous discharge rates in the chinchilla DCN. Evidence for noise-induced hyperactivity from our laboratory has been based almost entirely on multiunit recordings, raising the question of whether these increases refl ect increased discharge rates at the single unit level, or instead, might be due to some other change. Increased multiunit activity could result from increases in extracellular voltages caused by increases in single unit spike amplitude, increased synchronous discharges, increases in the number of active units, or breakdown in intercellular insulation (demyelination). The present study was undertaken to determine whether intense sound exposure causes increases in the discharge rates of single units in the DCN. We performed three separate experiments, each comparing spontaneous discharge rates of single units in the DCNs of tone-exposed and control hamsters. In each experiment, a different combination of electrode impedance, electrolyte solutions, exposure conditions and recovery times were used. Animals were exposed to an intense (115-127 dB SPL) 10 kHz tone for 4 hours, either while anesthetized or while awake and freely mobile. Post-exposure recovery times were varied from 5 to 30 days. Recordings were obtained from more than 200 units at varying depths below the DCN surface. The results from all three experiments revealed considerable overlap in the range of spontaneous rates recorded in the two animal groups. Despite this overlap, the mean single unit discharge rates from exposed animals were consistently higher than those from control animals and were statistically significant. These results make it likely that multiunit hyperactivity refl ects, at least in part, increases in single unit discharge rate. The possibility that one or more other factors might also contribute to multiunit hyperactivity cannot be ruled out. (Supported by NIH grant DC003258).

Correlated neural activity as the driving force for functional changes in auditory cortex.
Hear Res. 2007 Jan 16.
Eggermont JJ
Department of Physiology and Biophysics, Department of Psychology University of Calgary, 2500 University Drive N.W., Calgary, Alberta, Canada T2N 1N4
The functional role of neural synchrony is refl ected in cortical tonotopic map reorganization and in the emergence of pathological phenomena such as tinnitus. First of all experimenter-centered and subject centered views of neural activity will be contrasted; this argues against the use of stimulus-correction procedures and favors the use of a correction procedure based on neural activity without reference to stimulus timing. Within a cortical column neurons fi red synchronously with on average about 6% of their spikes in a 1ms bin and occasionally showing 30% or more of such coincident spikes. For electrode separations exceeding 200mum the average peak correlation strength only occasionally reached 3%. The experimental evidence for coincidence of neural activity, neural correlation and neural synchrony shows that horizontal fi bers activity can induce strong neural correlations. Cortico-cortical connections for a large part connect cell groups with characteristic frequencies differing by more than one octave. Such neurons have generally non-overlapping receptive fi elds but still can have sizeable peak cross-correlations.
Correlated neural activity and heterotopic neural interconnections are presented as the substrates for cortical reorganization; increased neural synchrony and tonotopic map reorganization go hand in hand. This links cortical reorganization with hypersynchrony that can be considered as an important driving force underlying tinnitus.

Cortical and subcortical fMRI of unilateral tinnitus.
(Abstract of ARO Meeting Denver, Colorado)
Cris Lanting1,2, Emile de Kleine1,2, Hilke Bartels1, Dave Langers1,2, Pim van Dijk1,2
1Department of Otorhinolaryngology / Head and Neck Surgery, University Medical Center Groningen,
2Fac. of Medical Sciences, School of Behavioral and Cognitive Neurosciences, University of Groningen
The current understanding of possible mechanisms of tinnitus generation is still poor. Our goal is to find a possible neural correlate of tinnitus, using fMRI.
In this work we used 10 patients (5 male) with unilateral tinnitus (5 left sided, 5 right sided) and 9 healthy subjects (4 male). Subjects had no or minor hearing defi cits in both ears (max. 30 dB HL). Experiments were performed on a 3T Philips Intera scanner. 41 coronal slices (2 mm) were acquired using a matrix of 128x128 voxels (1.75 x 1.75 mm2) using sparse sampling (TR=10 s). Stimuli consisted of right and left stimulation with levels of 40 and 70 dB (SPL) of rippled noise.
Data were realigned and normalized to a custom made template using SPM5. First level analysis was performed using multiple regression and regions of interest (ROI) of the auditory pathway were defi ned (cortex, MGB, IC, SOC and CN).
Percent signal changes were obtained for each condition for each region and symmetry indices were obtained. A second level analysis was performed using an ANOVA design to assess group differences and group-by-level interactions.
Results from the ROI analysis indicate that for the control group the cortex and inferior colliculus responded strongest to contralateral stimuli. A difference was observed between the two tinnitus patient groups. The left sided tinnitus group showed a predominant response towards ipsilateral stimuli at the cortex while the right sided tinnitus group responded more like the control group. A general trend of higher activation in the inferior colliculus as response to stimuli was observed in tinnitus patients compared to controls.
Our data suggest that there are differences in activation on cortex level and inferior colliculus level between the control group and the patient groups. Analysis of other nuclei will be performed.

Differential Expression of HCN Channels in the Cochlear Nucleus.
(Abstract of ARO Meeting Denver, Colorado)
Ana Caban Cardona, Rebecca Eernisse, Paul Popper, David Friedland
Medical College of Wisconsin
Hyperpolarization-activated currents (Ih) have been identified in many auditory brain stem neurons including octopus and bushy cells. The channels responsible for these currents are hyperpolarization-activated cyclic nucleotide-gated potassium channels of which four isoforms are known (i.e., HCN1-4). These channels influence resting membrane potentials, regulate neuronal excitability and likely play important roles in auditory signal processing. We used real-time RT-PCR and immunohistochemistry to investigate differential expression of all four HCN channels among the subdivisions of the cochlear nucleus. Higher levels of HCN2 and HCN4 mRNA were detected in the ventral subdivisions of the cochlear nucleus than in the DCN, although this did not reach statistical signifi cance. Real-time RT-PCR results for HCN1 and HCN3, in contrast, showed no differential expression. We found immunostaining for HCN2 and HCN4 in the DCN but no staining in this region for the other two channels. Our HCN2 labeling was predominantlyfound in cartwheel cells although previous reports have also shown HCN2 in fusiform cells. We found HCN4 to be most highly expressed in the fusiform cells. HCN4 was also noted among large neurons within the auditory nerve root. We found no neuronal staining for HCN3 in any subdivision and all HCN3 staining appeared localized to fi bers in the peri-neuronal spaces. Similar to other studies, we found strong HCN1 staining on octopus cells of the PVCN but in contrast to other studies we did not identify signifi cant staining in bushy cell regions. This study adds to the increasing evidence for differential expression among auditory neurons of the various hyperpolarization-activating potassium channels. The particular expression of HCN2 and HCN4, which are strongly regulated by cAMP, in the DCN may underlie some forms of neuronal plasticity such as that associated with noise-induced DCN hyperactivity and the generation of tinnitus (Supported by NIH/NIDCD K08DC006227).

Differential gene expression profiles in salicylate ototoxicity of the mouse.
(Abstract of ARO Meeting Denver, Colorado)
Gi Jung IM1, Seo Jin Kim2, Sung Won Chae1, Jae Hoon Cho1, Hak Hyun Jung1,2
1Department of Otolaryngology, Korea University College of Medicine, SEOUL, KOREA, 2Department of Biomedical Sciences, Korea University, SEOUL, KOREA
Conclusion: This study demonstrated differential gene expression profi les in salicylate ototoxicity with oligonucleotidemicroarray. This study may also provide basic information to candidate genes associated with hearing loss and/or tinnitus or recovery after salicylate-induced cochlear dysfunction.
Objectives: Salicylate ototoxicity is accompanied by temporary hearing loss and tinnitus. The purpose of the present study is to evaluate the gene expression profi les in the mouse cochlea with salicylate ototoxicity using DNA microarray.
Materials and Methods: The subject mice were injected intraperitoneally with 400 mg/kg of sodium salicylate, and an approximate 30 dB threshold shift that was observed by auditory brainstem response was achieved 3 hours after an injection of sodium salicylate and the hearing threshold returned to within normal range at 3 days. Differential gene expression profi les at 3 hours after salicylate injection in comparison to the normal cochlea were analyzed with DNA microarray technology. Results: The analysis of the ontogenic distribution was performed in up-regulated or down-regulated genes with the Gene Ontology Database system and GFINDer. Microarray revealed that 87 genes were up-regulated two-fold or more in the mouse cochlea with salicylate ototoxicity in comparison to the normal cochlea. Among these genes, increased expression levels of 30 functional genes were confirmed by semi-quantitative RT-PCR

The dorsal cochlear nucleus as a contributor to auditory and non-auditory components of tinnitus.
(Abstract of ARO Meeting Denver, Colorado)
James Kaltenbach
Waynes State University
The dorsal cochlear nucleus (DCN) has been modeled in numerous studies as a possible source of tinnitusgenerating signals. This hypothesis was originally developed on the basis of evidence that the DCN becomes hyperactive following exposure to intense noise. Since these early observations, evidence that the DCN is an important contributor to tinnitus has grown considerably. In this paper, the available evidence to date will be summarized. In addition, the DCN hypothesis of tinnitus can now be expanded to include possible involvement in other, non-auditory components of tinnitus. It will be shown by way of literature review that the DCN has direct connections with non-auditory brainstem structures, such as the locus coeruleus, reticular formation and raphe nuclei, that are implicated in the control of attention and emotional responses. The hypothesis will be presented that attentional and emotional disorders, such as anxiety and depression, which are commonly associated with tinnitus, may result from an interplay between these non-auditory brainstem structures and the DCN. Implicit in this hypothesis is that attempts to develop effective anti-tinnitus therapies are likely to benefit from a greater understanding of how the levels of activity in the DCN are influenced by different states of activation of these non-auditory brainstem structures and vice versa.

Effects of salicylate on spontaneous activity in brain slices of different central auditory structures.
(Abstract of ARO Meeting Denver, Colorado)
Dietmar Basta1,2, Romy Goetze2, Magdalena Sliwowska2, Arne Ernst1
1Dept. of ENT at ukb, University of Berlin, Germany, 2Institute of Biology Humboldt-University of Berlin, Germany
Salicylate is well known to produce tinnitus in humans and animals as well. It has been shown that systemic application of salicylate primarily changes outer hair cell electromotility and can infl uence neuronal activity in several parts of the auditory system. A direct action of salicylate on neurons of the inferior colliclus has been shown earlier in brain slice preparations. However, such an effect cannot be excluded for other parts of the central auditory pathway. The present study therefore investigated the in-vitro-effect of salicylate application on the single unit spontaneous activity in brain slices of the cochlear nucleus, medial geniculate body and primary auditory cortex. Single unit responses were extracellularly recorded in 200 µm thick slices of the related deafferentiated brain area. During the measurement of spontaneous activity, 1.4 mM sodium salicylate (corresponding to tinnitus related serum levels in rats (Cazals, 2000, Prog. Neurobiol. 62, 583-631)) were added by superfusion. Sixty seven percent of the neurons in the cochlear nucleus, 76 percent of the neurons in the medial geniculate body and 64 percent of the neurons in the primary auditory cortex responded with a significant and reversible change in fi ring rate during superfusion with salicylate. The mean value of absolute changes in neuronal fi ring rate was signifi cantly lower in the cochlear nucleus and primary auditory cortex than in the medial geniculate body. The response of neurons within the medial geniculate body was not significantly different to those obtained earlier from the inferior colliculus. The present data suggest that the auditory midbrain and thalamus plays a key role in the salicylate-induced tinnitus generation (Supported by the Sonnenfeld Foundation, Berlin, Germany).

Effects of Sodium Salicylate Induced Tinnitus on Auditory Cortex Local Field Potentials in Awake Rats.
(Abstract of ARO Meeting Denver, Colorado) '
Daniel Stolzberg1, Wei Sun1, Guang Yang2, Edward Lobarinas1, Richard Salvi1
1University at Buffalo, 2Yueyang Hospital of Shanghai Traditional Medical and Pharmacy University
Effects of Sodium Salicylate Induced Tinnitus on Auditory Cortex Local Field Potentials in Awake Rats Sodium salicylate (aspirin), a well known inducer of tinnitus in both humans and animals, has been used extensively to investigate the neurophysiological correlates of tinnitus in animal models. Despite the fact that tinnitus is only perceived when subjects are conscious, nearly all of the neurophysiological studies of tinnitus carried out to date have been carried out under anesthetics which disrupt or alter the neural process that give rise to this phantom auditory sensation. To avoid the confounding effects of anesthetics, we carried out a series of experiments in which we measured the tone-burst evoked, local fi eld potential from the auditory cortex (AC) of conscious rats before and after administering a high dose (250 mg/kg, i.p.) of salicylate known to produce behavioral signs of tinnitus around 16 kHz. A chronic, electrode implanted on the AC was used to record the cortical evoked potential in response to tone bursts presentedat 4, 8, 12, 16, 24 and 32 kHz. Sound level was increased from the animal's threshold up to 90 dB SPL. Preliminary recordings showed that salicylate caused an increase in the peak-to-peak amplitude of the AC evoked response at 2 h and 6 h post-treatment. The largest amplitude increase, on the order of 80%, occurred at 16 kHz around 90 dB SPL (p<0.05). The salicylate-induced amplitude enhancement was noticeably less at frequencies below 16 kHz (45-55%, 4-12 kHz) and above 16 kHz (35-55%, 24-32 kHz). The AC amplitude enhancement was greatest at 2 h post-salicylate and decreased slightly at 6h post-treatment, except at 16 kHz where there was a slight amplitude increases (Supported in part by grant from the Tinnitus Research Consortium).

Effects of somatosensory electrical stimulation on neural activity of the dorsal cochlear nucleus of hamsters.
(Abstract of ARO Meeting Denver, Colorado)
Jinsheng Zhang1,2, Zhenlong Guan1,3
1Department of Otolaryngology, Wayne State University School of Medicine, 2Department of Communication
Sciences & Disorders, Wayne State Univ College of Liberal Arts & Science, 3Department of Zoology, Hebei Normal University College of Life Sciences
It has been shown that sound exposure induces hyperactivity in the dorsal cochlear nucleus (DCN) in hamsters, rats and chinchillas. This hyperactivity has been demonstrated to be correlated with the behavioural evidence for tinnitus. It is conceivable that suppression of hyperactivity in the DCN would suppress tinnitus. Somatosensory electrical stimulation (SES) has been used clinically to suppress tinnitus.
However, due to a lack of understanding of the mechanisms of tinnitus suppression through SES, this approach has not been developed as an effective and reliable means for treating tinnitus. The current study was to test the effects of SES by delivering electrical current to the basal part of the pinna on DCN activity of both control and tone-exposed animals. Experiments were carried out in 26 adult hamsters, among which 13 were exposed to an intense tone under anesthesia (10 kHz tone, 125-130 dB SPL, 4 hrs) and another 13 age-matched control animals were similarly anesthetized but not exposed to a sound. One to three weeks after sound exposure and control treatment, multiunit activity was recordedat the surface of the left DCN before, during and after electrical stimulation of the left pinna. Electrical stimuli were single biphasic pulses of 200 us duration, delivered at 100-900 uA and 100 pps. The results from both control and exposed groups revealed four response types: S-S, referring to suppression during and after stimulation; E-S, manifesting excitation during stimulation but suppression after stimulation; S-E, showing suppression during stimulation but excitation after stimulation; E-E, representing excitation during and after stimulation.
We found that there were more incidences of suppression than excitation during and after stimulation in both control and exposed groups. At higher levels of current, there was a signifi cantly higher degree of suppression after stimulation than during stimulation for both groups, and there was also higher degree of suppression during and after stimulation in exposed animals than in controls. Our results are in line with previous clinical fi ndings and support the view that DCN hyperactivity may be the direct neural correlate of tinnitus and suppression of DCN hyperactivity through SES may be one important approach in tinnitus suppression. (Supported by ATA).

GABAA Receptor Subunit Changes in a Noise-Exposure Model of Tinnitus: Rat Medial Geniculate Body.
(Abstract of ARO Meeting Denver, Colorado)
Donald Caspary1,2, Danyelle Martin3, Lynne Ling1, Hongning Wang1, Pete Hutson4, Jeremy Turner2,5, Emma Reuschel6, Larry Hughes2
1Department of Pharmacology, Southern Illinois University School of Medicine, 2Department of Surgery/Otolaryngology, Southern Illinois University School of Medicine, 3Department of Microbiology, Universityof Illinois at Chicago, 4Department of Sleep and Schizophrenia Research, Merck Inc., 5Department of Psychology, Illinois College, 6Department of Chemistry and Biology, Illinois College
The medial geniculate body (MGB) is the major auditory thalamic nucleus. MGB receives segregated ascending inputs from the inferior colliculus and descending cortical inputs from auditory cortex and nonauditory cortices. Previous studies have reported noise-induced evidence of tinnitus in the central auditory system. The present study examined selective GABAA receptor subunit changes three months following a 16kHz octave-band, 115dB noise-exposure, thought to induce tinnitus in rats. Two non "wild-type" GABAA receptor subunits, the a4 and d subunits appear to be concentrated in synaptic and extra-synaptic constructs in MGB. Subunit message levels were quantifi ed using in situ hybridization and subunit proteins were visualized using fl uorescent immunocytochemistry in young and aged noise-exposed rats compared to young and aged unexposed controls. Young noise-exposed rats showed signifi cant upregulation of the a4 subunit in both ipsi- and contralateral MGB (>50% increase), while aged rats showeda4 subunit upregulation in the contralateral MGB (>100%increase). Young and aged noise-exposed rats showed signifi cant d subunit upregulation in the MGB (dorsal, young>48%; aged>103%; ventral, young>84%; aged>170%) contralateral to the noise exposure.
It has been proposed (Sur et al., 1999) that upregulation of a a4ßd GABAA receptor construct may be a compensatory plastic change to offset hyperactive neuronal networks. The present GABAA receptor subunit changes suggest that noise exposure related changes in MGB may, in part, subserve the per cept of tinnitus. Age-related differences in subunit plasticity associated with noise-exposure might provideinsights into the increased incidence of tinnitus in the elderly (Supported in part by American Tinnitus Association, NIH DC00151, and Merck Inc.).

Hypoxic changes of central nervous system in noise-exposed mouse.
(Abstract of ARO Meeting Denver, Colorado)
Young-Jin Kim1, Hun Hee Kang2, Joong Ho Ahn2, Kwang-Sun Lee2, Jong Woo Chung2
1Daejin medical center, 2Asan medical center
Background and objectives: When noise-induced hearing loss occurs, hypoxia is detected in inner ear tissues. In previous study noise-induced inner ear hypoxia was proved by the increase of HIF-1a, which is expressed? in the nucleus under hypoxic condition. Another hypoxic marker, pimonidazole is also widely used to see the hypoxic area by injection from outside. Existence of tinnitus or hyperacusis with noise-induced hearing change may suggest the change of central nervous system, but no exact site or timing of change is alleged until now. The study is designed to investigate the sitespecifi c hypoxic change in central auditory pathway during noise induced threshold shift.
Materials and Methods: Fifty six BALB/c hybrid mice with normal hearing were exposed to 120 dB SPL broad band noise for 3 hours. Immediately after noise and 7 days after noise exposure, the brains of mice were extracted. They were cryosectioned by 15 (m thickness and examined by immunofl uorescence using monoclonal antibody of HIF-1a and pimonidazole HCL (hypoxyprobe(-1).
Result: After noise, the hearing thresholds of mice decreased to 49.5 ( 8.0 dB HL and the hearing were recovered to 27.9 ( 4.3 dB HL in 7 days. In the coronal section of brain, HIF-1a was detected immediately after noise in the auditory cortex, hippocampus and inferior colliculus. At least for 7 days, these signals persisted although without additional noise exposure. When the same slides were double stained by hypoxyprobe(-1, auditory cortex, hippocampus and inferior colliculus showed more localized hypoxic signals. The uptake of pimonidazole increased after 7 days.
Conclusion: In noise-induced transient threshold shift, hypoxia occurred in central nervous system and it persisted until 7 days, even though hearing was recovered. These changes were sensitive in auditory cortex and hippocampus.
Key words: Noise-induced hearing loss, Central nervous system, Hypoxia, Hypoxia-inducible factor 1a, Pimonidazole

Molecular Correlates of Noise-Induced Tinnitus:Alterations in Gene Expression Infl uencing Inhibition in the Dorsal Cochlear Nucleus.
(Abstract of ARO Meeting Denver, Colorado)
Avril Genene Holt1, Catherine Lomax2, Susan Land1, James Kaltenbach1
1Wayne State University, 2University of Michigan
Noise-induced tinnitus can be a debilitating condition that decreases quality of life. A hallmark of noiseinduced central tinnitus is thought to be a change in the balance between inhibition and excitation with sustained increases in spontaneous neuronal activity that begin in the dorsal cochlear nucleus (DCN). To explore mechanisms involved in this imbalance we screened nine genes infl uencing inhibitory neurotransmission in the DCN for changes in expression at different times following noise exposure. Animals were divided into ten groups: half were exposed to an intense (125-130 dB SPL) 10 kHz tone for 4hours, and half were age matched unexposed controls. Exposed animals were assessed at each of 5 different post-exposure recovery times: 0d, 2d, 5d, 14d and 29 days. The expression of nine genes, four glycine receptor genes (glyR1a, glyR2a, glyR3a, glyRb), four muscarinic receptors (muscR2, muscR3, muscR4, muscR5), and ChaT were assessed across groups. Each experimental group consisted of 3 RNA pools for each time-point, comprised of the DCN from three rats. Real time RT-PCR indicates that the DCN has some normal level of expression for each gene examined. In exposed animals, most glycine receptorsubunits showed a trend towards an initial increase in expression followed by a decline in gene expression; however only glyR2a showed statistically signifi cant increases in expression at the 0 (p <= 0.035) and 5 (p <= 0.020) day time points with a return to normal expression levels by 29 days. A similar trend was seen among muscarinic receptors with increased expression immediately after exposure, followed by decreased expression at later time points. Again, only one of the receptors showed a statistically signifi cant change in expression with muscR4 having decreased levels two (p <= 0.025) and fi ve (p<= 0.033) days after exposure. Compared with agematched controls, ChAT expression after noise exposure showed a different temporal pattern from those of glycine and muscarinic receptors, with no change in gene expression at the 0 day time point, a sustained increase in expression that was statistically signifi cant by the 14 day time point (p <= 0.038) and a 65% decrease in expression at the 29 day time point (p <= 0.084).
These results suggest that alterations in the expression of neurotransmitter receptors infl uencing inhibition are among the changes occurring in the DCN that are thought to underlie noise-induced tinnitus (Supported by R01 DC003258 to JAK).

The neural code of auditory phantom perception.
J Neurosci. 2007 Feb 7;27(6):1479-1484.
Weisz N, Muller S, Schlee W, Dohrmann K, Hartmann T, Elbert T
Department of Psychology, University of Konstanz, D-78464 Konstanz, Germany.
weisz@lyon.inserm.fr
Tinnitus is defined by an auditory perception in the absence of an external source of sound. This condition provides the distinctive possibility of extracting neural coding of perceptual representation. Previously, we had established that tinnitus is characterized by enhanced magnetic slow-wave activity (approximately4 Hz) in perisylvian or putatively auditory regions. Because of works linking high-frequency oscillations to conscious sensory perception and positive symptoms in a variety of disorders, we examined gamma band activity during brief periods of marked enhancement of slow-wave activity. These periods were extracted from 5 min of resting spontaneous magnetoencephalography activity in 26 tinnitus and 21 control subjects. Results revealed the following, particularly within a frequency range of 50-60 Hz: (1) Both groups showed signifi cant increases in gamma band activity after onset of slow waves. (2) Gamma is more prominent in tinnitus subjects than in controls. (3) Activity at approximately 55 Hz determines the laterality of the tinnitus perception. Based on present and previous results, we have concluded that cochlear damage, or similar types of deafferentation from peripheral input, triggers reorganization in the central auditory system. This produces permanent alterations in the ongoing oscillatory dynamics at the higher layers of the auditory hierarchical stream. The change results in enhanced slow-wave activity reflecting altered corticothalamic and corticolimbic interplay. Such enhancement facilitates and sustains gamma activity as a neural code of phantom perception, in this case auditory.

Piezoelectricity increases outer hair cell high frequency response.
(Abstract of ARO Meeting Denver, Colorado)
Ning Yu, Hong-Bo Zhao
University of Kentucky Medical Center
Outer hair cell (OHC) electromotility is a cochlear amplifier and can actively boost the basilar membrane vibration to enhance auditory sensitivity and frequency selectivity. OHC electromotility is membrane-potential dependent and driven by cross-membrane voltage. Although the conformation of prestin motor proteins can be rapidly changed up to 100 kHz, its driving force (cross-membrane voltage) would be dramatically attenuated at high frequency by membrane capacitance, which forms a low-pass filter with cut-frequency less than 1 kHz. Outer hair cells also have remarkable piezoelectricity. Mechanically elongating and compressing OHC can produce electric currents. Here, we report that OHC piezoelectricity can overcome membrane capacitance damping to improve OHC high frequency responses. The OHC piezoelectric response showed a high-pass property and was increased as the stimulus frequency was increased. The cut-frequency was 70-90 kHz, mainly limited by the recording system. Simultaneous administrations of electronic and mechanical (piezoelectric) stimulation to the OHC, which mimics the OHC suffered electronic (receptor current through transduction channels) and mechanical (the vibration of the basilar membrane) stimulations in vivo, generated the fl at response up to 80 kHz. Abolishment of piezoelectricity eliminated this high frequency enhancement. Like a regular cell,the sole electronic frequency response of the OHC was low-pass; the cut-frequency was ~1 kHz. Finally,as computer modeling expected, the resonant peaks were also visible in the responses to electronic-mechanical stimulation. Our results indicate that OHC electromotility can perform at high frequency effectively to contribute active cochlear mechanics in whole mammalian auditory frequency range (Supported by NIH DC05989 and the Research Foundation of American Tinnitus Association).

Pre- and Postsynaptic Changes Underlying the Maturation of Inner Hair Cell Ribbon Synapses Do Not Depend on the Onset of Hearing.
(Abstract of ARO Meeting Denver, Colorado)
Michel Eybalin1, Nicole Renard1, Annelies Schrott-Fischer2, Jean-Luc Puel1
1INSERM U583, Montpellier, France, 2ENT Department, Innsbruck, Austria
Inner hair cell (IHC) synapses play a key role in the auditory physiology as they ensure transmission of sound stimuli to fi rst auditory neurons. Glutamate is the neurotransmitter responsible for this fast synaptic transmission which essentially involves AMPA receptors. The glutamate release is dependent on Ltype Ca2+ channels with Cav1.3 subunit and occurs at synapses equipped with a dense ribbon thought to mediate the continuous and rapid recruitment of its attached vesicles to the release sites. Despite the importance of the IHC synapse, the cellular and molecular machineries underlying its function are still largely unknown despite their elucidation is of prime importance to gain insight into the occurrence of tinnitus and most forms of deafness.
Using immunocytochemistry, we have studied the expression of a selected set of presynaptic proteins (SNAP25, cysteinestring protein, Rab3 and synaptogyrin) during the postnatal maturation of the rodent cochlea and found that, with the exception of Rab3, they were only detected starting postnatal days 10 and 12, when the fi rst, immature, cochlear potentials can be recorded. During the same postnatal period, we also found that the composition and pharmacological properties of the postsynaptic AMPA receptors changed. GluR2 replaced GluR1 at postnatal day 10, switching the potential composition of AMPA receptors from GluR1/3/4 to GluR2/3/4 and their pharmacology to calcium impermeability. Finally, we have checked the expression of GluR2 and the 4 presynaptic proteins in the cochlea of the deaf Cav1.3 knock out mice and found that they were all expressed at adult IHC synapses suggesting that their expression was not dependent of the fi rst sound stimuli transduced by IHCs.

Quinine Induced Tinnitus-like Behavior Using a Startled Refl ex Paradigm.
(Abstract of ARO Meeting Denver, Colorado)
Edward Lobarinas, Wei Sun, Lei Wei, Richard Salvi
University at Buffalo
The anti-malarial drug, quinine, has been reported to induce tinnitus when administered at high doses and has been used to investigate the neural and biochemical mechanisms underlying tinnitus. Previously, schedule induced polydipsia avoidance conditioning (SIP-AC) was used to evaluate the presence of tinnitus in rats treated with high doses of both salicylate and quinine. Recently, the effects of quinine on tinnitus-like behavior were evaluated using a high-throughput behavioral assay, gap pre-pulse inhibition of acoustic startle (GPIAS), which can be used to estimate tinnitus pitch. GPIAS was used to measure the onset and pitch of quinine-induced tinnitus in rats treated with different doses of quinine. A 50 ms silent gap (gap pre-pulse) in a continuous background noise was used to inhibit the startle refl ex elicited by a high level noise burst. The gap was embedded in narrow band noises (NBN) with center frequencies at 6, 12, 16 or 24 kHz. Noise burst pre-pulse inhibition of acoustic startle (NBIAS) was also evaluated to monitor potential changes in hearing following quinine. GPIAS results showed evidence of tinnitus like behavior at frequencies above 6 kHz with no changes in hearing threshold at doses of quinine up to 150 mg/kg. Tinnitus-like behaviors with GPIAS were consistent with previous SIP-AC data, strengthening the use of GPIAS as an animal model of tinnitus (Supported in part by Tinnitus Research Consortium).

Salicylate-induced tinnitus: effects of salicylate on neurons in dorsal cochlear nucleus.
(Abstract of ARO Meeting Denver, Colorado)
Lei Wei, Wei Sun, Dalian Ding, Matthew Xu-Friedman, Richard Salvi
University at Buffalo
The neural mechanisms for tinnitus are not well understood, but one hypothesis is that it originates fromhigh rates of spontaneous activity in the dorsal cochlear nucleus (DCN). Support for this hypothesis has come from studies showing elevated spontaneous rates in the DCN following noise and cisplatin-induced hearing loss. High doses of sodium salicylate reliably induce tinnitus, but it is unclear what effects salicylate has on spontaneous activity in the DCN. To test this hypothesis, we prepared brain slices of the DCN from p13-20 rats and recorded the spontaneous fi ring rate of individual neurons before, during and after treatment with 1.4 mM salicylate. This concentration of salicylate in CSF has been shown to induce behavioral manifestations of tinnitus in rats. Recordings were obtained from three cell types, fusiform, cartwheel and giant cells, with identifi cations based on their morphological and/or physiological characteristics. The spontaneous spike rate of cartwheel and giant cells remained unchanged or increased slightly after salicylate perfusion. In contrast, the spontaneous spike rate of most fusiform cells decreased signifi cantly after salicylate treatment. The results indicate that the effects of salicylate are specific to fusiform cells. Spontaneous spike rate partially recovered following brief (3-5 min) salicylate perfusion and wash-out. The recovery of spontaneous spike rate in fusiform cells was inversely related to perfusion duration and salicylate concentration. To determine if the decrease in spontaneous rate was induced by changes in synaptic activity, we recorded spontaneous post-synaptic currents in voltage clamp. No signifi cant change was seen after salicylate treatment. These results suggest that the salicylate-induced decrease in spontaneous rate in fusiform cells is unlikely to be due a change in synaptic input, but may involve changes in the cell's intrinsic properties (Supported in part by Tinnitus Research Consortium).

The sound of stress: blunted cortisol reactivity to psychosocial stress in tinnitus sufferers.
Neurosci Lett. 2007 Jan 10;411(2):138-142.
Hebert S, Lupien SJ
Ecole d'orthophonie et d'audiologie, Universite de Montreal, Canada; Centre de recherche, Institut universitairede geriatrie de Montreal, Canada.
sylvie.hebert@umontreal.ca
Clinical observations suggest that tinnitus is modulated by stress. However, there is little empirical data to support the link between stress and tinnitus. In this study, we measured the stress hormone cortisol to examine the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis in tinnitus participants as well as in healthy controls without tinnitus. Eighteen participants with tinnitus and 18 controls without tinnitus were exposed to the Trier Social Stress Task and cortisol sampling and subjective ratings were obtained at regular intervals. Tinnitus participants displayed a blunted cortisol response to psychosocial stress, in comparison with healthy controls who had a typical cortisol release about 30 min after the beginning of the experiment. The blunted cortisol response displayed by the tinnitus participants suggests that they have an anomaly along the HPA axis. Their cortisol response is similar to that found in other bodily stress-related diseases and thus suggests that tinnitus is related to stress. However, tinnitus intensity might not be modulated by stress in a concurrent manner.

Suppression of verbal hallucinations and changes in regional cerebral blood flow after intravenous lidocaine: a case report.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):301-303.
Plewnia C, Bischof F, Reimold M
Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D-72076 Tuebingen, Germany. christian.plewnia@uni-tuebingen.de
Simple and complex auditory phantom-perceptions such as tinnitus and musical hallucinations occur predominantly in elderly subjects and are often associated with hearing impairment. Isolated verbal hallucinations without other psychotic features are rare. It has been shown that an intravenous (i.v.) injectionof lidocaine can transiently suppress tinnitus. Here we present the case of a 74 year old left-handed women with severely distressing, continuous verbal auditory hallucinations without other psychotic features. I.v. injections of 100 mg lidocaine but not saline resulted in substantial transient suppressions of the hallucinations for several hours. Using [(15)O]H(2)O positron-emission tomography (PET) decreased regional cerebral blood fl ow associated with reduced perception of voices was found in the right angular and supramarginal gyrus, right inferior frontal gyrus, orbitofronal cortex and in major parts of the cingulated cortex. These data suggest to further investigate the clinical relevance of i.v. lidocaine in patients with therapy-resistant verbal hallucinations, support the notion of common pathophysiological mechanisms in different forms of auditory phantom-perception and demonstrate the feasibility of a new strategy forimaging studies on auditory hallucinations.

Time course of recovery of spontaneous activity (SA) in the rat inferior colliculus (IC) following unilateral acoustic trauma
(Abstract of ARO Meeting Denver, Colorado)
Thomas Imig1, Henry Heffner2, Gim Koay2, Dianne Durham1
1Kansas University Medical Center, 2University of Toledo
SA in the IC of rats was measured following unilateral acoustic trauma (isofl urane anesthesia, continuous 16 kHz tone for 60', 115 - 120 dB SPL). At various times following sound exposure, unanesthetized rats were injected with C14 labeled 2 deoxyglucose (2DG) and placed in a quiet sound isolation chamber during uptake. Groups of 4 rats each received 2DG at different times following exposure (4 hour, 1, 2, 4, 8, 16 day, and control). Optical density (OD) measures were obtained from autoradiographs at 10 equally spaced segments that crossed the tonotopic axis of the central nucleus (ICc) and the external nucleus (ICx). OD for corresponding segments of ipsi and contra IC were compared and showed the following results: 1. OD was bilaterally symmetrical in controls. In exposed rats the contra IC showed a decrement in OD with respect to the ipsi IC at each survival time. Acoustic trauma did not cause an increase in OD at any survival time. 2. SA in contra IC showed partial recovery over time. The greatest decrement in OD was seen at 4 hours with lesser decrements at longer times. 3. Recovery of SA followed different time courses in the ICx and ICc. The decrement in OD extended throughout both the ICc and ICx at four hours. By 2 days, ICx showed full recovery (bilaterally symmetrical OD) but recovery in the contra ICc continued over an 8 day period. 4. Recovery of SA in the ICc showed a low (LF) to high frequency (HF) progression. In 4 h and 1 day groups, SA was decreased throughout the ICc with the greatest decrement in the HF half of the ICc. By 8 days SA recovered to normal levels in LF ICc. The HF half of the ICc showed a decrement in SA, although less so than at earlier times. There was no further change in SA at 16 days (Supported by the Tinnitus Research Consortium and MRRC Center Grant HD02528).

Tinnitus and neural plasticity of the brain.
Otol Neurotol. 2007 Feb;28(2):178-184.
Bartels H, Staal MJ, Albers FW
Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands. h.bartels@kno.umcg.nl
Objective: To describe the current ideas about the manifestations of neural plasticity in generating tinnitus.
Data sources: Recently published source articles were identifi ed using MEDLINE, PubMed, and Cochrane Library according to the key words mentioned below.
Study selection: Review articles and controlled trials were particularly selected.
Data extraction: Data were selected systematically, scaled on validity and comparability.
Conclusion: An altered afferent input to the auditory pathway may be the initiator of a complex sequence of events, finally resulting in the generation of tinnitus at the central level of the auditory nervous system. The effects of neural plasticity can generally be divided into early modifications and modifications with a later onset. The unmasking of dormant synapses, diminishing of (surround) inhibition and initiation of generation of new connections through axonal sprouting are early manifestations of neural plasticity, resulting in lateral spread of neural activity and development of hyperexcitability regions in the central nervous system. The remodeling process of tonotopic receptive fields within auditory pathway structures (dorsal cochlear nucleus, inferior colliculus, and the auditory cortex) are late manifestations of neural plasticity. The modulation of tinnitus by stimulating somatosensory or visual systems in some people with tinnitus might be explained via the generation of tinnitus following the nonclassical pathway. The similarities between the pathophysiological processes of phantom pain sensations and tinnitus havestimulated the theory that chronic tinnitus is an auditory phantom perception.

Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma.
Neuroscience. 2007 Jan 31.
Tan J, Ruttiger L, Panford-Walsh R, Singer W, Schulze H, Kilian SB, Hadjab S, Zimmermann U, Kopschall I, Rohbock K, Knipper M
University of Tubingen, Department of Otorhinolaryngology, Hearing Research CenterTubingen, MolecularNeurobiology, Elfriede-Aulhorn-Strasse 5, 72076 Tubingen, Germany.
The molecular changes following sensory trauma and the subsequent response of the CNS are poorly understood. We focused on fi nding a molecular tool for monitoring the features of excitability which occur following acoustic trauma to the auditory system. Of particular interest are genes that alter their expression pattern during activity-induced changes in synaptic effi cacy and plasticity. The expression of brain-derived neurotrophic factor (BDNF), the activity-dependent cytoskeletal protein (Arg3.1/arc), and the immediate early gene c-Fos were monitored in the peripheral and central auditory system hours and days following a traumatic acoustic stimulus that induced not only hearing loss but also phantom auditory perception (tinnitus), as shown in rodent animal behavior models. A reciprocal responsiveness of activitydependent genes became evident between the periphery and the primary auditory cortex (AI): as c-Fos and BDNF exon IV expression was increased in spiral ganglion neurons, Arg3.1/arc and (later on) BDNF exon IV expression was reduced in AI. In line with studies indicating increased spontaneous spike activity at the level of the inferior colliculus (IC), an increase in BDNF and GABA-positive neurons was seen in the IC. The data clearly indicate the usefulness of Arg3.1/arc and BDNF for monitoring trauma-induced activity changes and the associated putative plasticity responses in the auditory system.

VIII Somatic tinnitus

Somatic modulation of tinnitus: test reliability and results after repetitive muscle contraction training.
Ann Otol Rhinol Laryngol. 2007 Jan;116(1):30-35.
Sanchez TG, da Silva Lima A, Brandao AL, Lorenzi MC, Bento RF
Department of Otolaryngology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Objectives: We sought to study the reliability of tinnitus modulation by muscle contractions and to observethe effect of their prolonged repetition.
Methods: Thirty-eight patients with tinnitus underwent 9 maneuvers of muscle contractions in test and retest situations. After a 2-month training period of repeating the maneuvers, tinnitus modulation anddaily perception were evaluated.
Results: There was no difference between the occurrence of tinnitus modulation in test (57.9%) and retest (63.2%) situations. After 2 months, the occurrence of modulation during the maneuvers was similar (55.3%), but a new pattern showed an increase in tinnitus improvement and a decrease in tinnitusworsening. The daily perception of tinnitus was unchanged.
Conclusions: Maneuvers of head and neck muscle contractions evoked tinnitus modulation in a frequent and reliable manner. Also, the repetition of such maneuvers for 2 months altered the pattern of modulation.

Tensor tympani muscle: strange chewing muscle.
Med Oral Patol Oral Cir Bucal. 2007 Mar 1;12(2):E96-E100.
Ramirez LM, Ballesteros LE, Sandoval GP
Universidad Javeriana, Santa fe de Bogota, Colombia. lmra3@yahoo.com
This work seeks to alert medical and odontological staff to understanding and using interdisciplinary handling for detecting different pathologies common otic symptoms. It offers better tools for this shared symptomatology during therapy s conservative phase. Tensor tympani muscle physiology and function in the middle ear have been veiled, even when their dysfunction and anatomical relationships may explain a group of confused otic symptoms during conventional clinical evaluation. Middle ear muscles share a common embryological and functional origin with chewing and facial muscles. This article emphasizesthat these muscles share a functional neurological and anatomical dimension with the stomatognathic system; these muscles increased tonicity ceases to be a phenomenon having no logical connections. It offers functionality and importance in understanding referred otic symptoms in common with other extraotical symptom pathologies. Tinnitus, vertigo, otic fullness sensation, hyperacusia, hypoacusia and otalgia are not only primary hearing organ symptoms. They should be redefined and related to the neighboring pathologies which can produce them. There is a need to understand temporomandibular disorders and craniofacial referred symptomatology from neurophysiologic and muscle-skeletal angles contained in the stomatognathic system. Common symptomatology is frequently observed in otic symptoms and temporomandibular disorders during daily practice; this should be understood by each discipline from a broad, anatomical and clinical perspective.

IX Surgical treatment

How does stapes surgery infl uence severe disabling tinnitus in otosclerosis patients?
Adv Otorhinolaryngol. 2007;65:343-347.
Oliveira CA
Department of Otolaryngology, Brasilia University Medical School, Brasilia, Brazil.
cacpoliveira@brturbo.com.br
Tinnitus is a common symptom in otosclerosis patients. Many papers have been written about tinnitus outcome after stapes surgery. However, none has attempted to quantify the intensity of the symptom preand postoperatively in order to evaluate the infl uence of surgery on the degree of annoyance caused by tinnitus. Severe disabling tinnitus (SDT) is defi ned by Shulman as a symptom severe enough to disrupt the patient's routine and to prevent him from performing his daily tasks. We have studied 48 consecutive otosclerosis patients by means of a visual analogue scale measuring tinnitus intensity before and after stapes surgery. We have accepted tinnitus as severe and disabling when the symptom score was 7 or above in a visual analogue scale from 1 to 10. Of 19 patients with preoperative SDT, 10 reported complete remission and 7 reported signifi cant improvement. Two patients had no change and none reported worsening of tinnitus after stapes surgery. We conclude that stapes surgery can improve SDT signifi cantly in 90% of otosclerosis patients and is very unlikely to make the symptom worse.

Sigmoid sinus diverticulum: a new surgical approach to the correction of pulsatile tinnitus.
Otol Neurotol. 2007 Jan;28(1):48-53.
Otto KJ, Hudgins PA, Abdelkafy W, Mattox DE
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Objective: Tinnitus represents a bothersome symptom not infrequently encountered in an otology practice. Tinnitus can be the harbinger of identifi able middle or inner ear abnormality; but more frequently,tinnitus stands alone as a subjective symptom with no easy treatment. When a patient complains of tinnitus that is pulsatile in nature, a thorough workup is indicated to rule out vascular abnormality. We report of a new diagnostic fi nding and method of surgical correction for select patients with pulsatile tinnitus.
Study design: Retrospective case series.
Setting: Tertiary care, academic referral center.
Patients: Among patients seen for complaints of unilateral or bilateral pulsatile tinnitus, fi ve were identified with diverticula of the sigmoid sinus. All patients had normal in-offi ce otoscopic, tympanometric, and audiometric evaluations. Patients with paragangliomas or benign intracranial hypertension were excluded. Auscultation of the pinna or mastoid revealed an audible bruit in most patients. All patients underwent computed tomographic angiography of the temporal bone. In all cases, this fi nding was on the side coincident with the tinnitus.
Intervention: Three of five patients underwent transmastoid reconstruction of the sigmoid sinus. Main outcome messure: Patients were evaluated clinically for presence or absence of pulsatile tinnitus after reconstructive surgery.
Results: All patients electing surgical reconstruction had immediate and lasting resolution of the tinnitus.
Conclusion: Surgical reconstruction can provide lasting symptom relief for patients with pulsatile tinnitus and computed tomographic evidence of a sigmoid sinus diverticulum.

X Epidemiology

The extent and levels of tinnitus in children of central Ankara.
Int J Pediatr Otorhinolaryngol. 2007 Feb;71(2):263-8. Epub 2006 Nov 28.
Aksoy S, Akdogan O, Gedikli Y, Belgin E
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Audiology and Speech Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
songulaksoy@hotmail.com
Objective: The objective of this study is to determine the presence and prevalence of tinnitus among primary school and junior high school students in central Ankara.
Methods: In the first stage of the study, all students were tested for the presence of tinnitus by answering a comprehensive questionnaire. The students who had previous ear operations were excluded from the rest of the study. The initial survey/tests yielded presence of tinnitus, frequency of occurrence, characteristics, associated symptoms and the age groups.
Results: 15.1% of the children reported to have tinnitus. No signifi cant difference was found between gender (female 45.5%, male 54.4%) and ears (right 25.3%, left 25.5%). The age group that suffered most from tinnitus is 14 years old (20.8%), 25 children had positive family history (16.2%), 44 children had headaches as the most common accompanying symptom (28.6%), 64 of them had tiredness as the predisposing factor (41.6%) and 52 of them have defi ned worsening of tinnitus during mornings (33.8%). The characteristics of tinnitus were identifi ed as high pitch (n=125, 81.2%), soft loudness (n=124, 80.5%) and ringing (n=61, 39.6%).
Conclusions: The study produced much needed data to shed light onto understanding levels and characteristics of tinnitus in school children in Turkey. The data obtained was carefully analyzed and found to be comparative to international studies.

XI Review

Tinnitus.
J Laryngol Otol. 2007 Mar;121(3):201-208.
McFerran DJ, Phillips JS
Department of Otolaryngology and Head and Neck Surgery, Essex County Hospital, Colchester, UK.
Chronic idiopathic subjective tinnitus is a common condition affecting around one in ten of the populationat any given time. For the majority of people it is an annoyance rather than a major health issue but for approximately 0.5 per cent of the population tinnitus interferes with their ability to pursue a normal life. Modern theories of the pathogenesis of the condition concentrate on the central auditory system although the peripheral auditory system can be a trigger or ignition site for tinnitus. Although a cure remains elusive there are several good treatment strategies based on psychological and neurophysiological models of tinnitus that promote habituation to the symptom.

[Compensation for tinnitus in private accident insurance].
Laryngorhinootologie. 2007 Jan;86(1):27-36. [Article in German].
Michel O, Brusis T
Klinik und Poliklinik fur Hals-Nasen-Ohren-Heilkunde, Universität zu Koln, Koln. Michel@uni-koeln.de
According to the provisions of private accident insurance, mental or psychic reactions are excluded from compensation. Until now, tinnitus was taken as fully psychic and therefore excluded. In two recently published judgments of the Federal Supreme Court in Germany the assessment of tinnitus in private accident insurance and particularly the exclusion clause section sign 2 Abs. 4 AUB 88 has been newly defined. According to this actual jurisdiction the compensation of tinnitus could be possible, when as physical underlying reason a proved harm in the inner ear or the auditory pathway (hearing loss), which can be traced back to the accident according to the rules of causality. This leads to the question how Tinnitus could be compensated without modification of the general terms and conditions of the private accident insurance. A compensating table is proposed, which recognizes the somatic (physical) part of tinnitus and is based on medical and scientifi c fi ndings of the relation between hearing loss and tinnitus.

Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus.
Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004739.
Bennett M, Kertesz T, Yeung P
Background: Idiopathic sudden sensorineural hearing loss (ISSHL) with or without tinnitus is common and presents a health problem with signifi cant effect on quality of life. Hyperbaric oxygen therapy(HBOT) may improve oxygen supply to the inner ear and, it is postulated, may result in an improvement in hearing and/or a reduction in the intensity of tinnitus.
Objectives: To assess the benefits and harms of HBOT for treating ISSHL and/or tinnitus.
Search strategy: We initially searched in June 2004 and repeated the search in June 2006. Our search included the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 2 2006), MEDLINE (1951 to 2006), EMBASE (1974 to 2006), CINAHL, Database of Randomised Trials in Hyperbaric Medicine (DORCTHIM), AMED, LILACS, KOREAMED, INDMED, National Research Register (NRR), CSA, ISI PROCEEDINGS and ZETOC.
Selection criteria: Randomised studies comparing the effect on ISSHL and/or tinnitus of therapeutic regimens which include HBOT with those that exclude HBOT.
Data collection and analysis: Three authors independently evaluated the quality of the relevant trials using the validated Oxford-Scale (Jadad 1996) and extracted the data from the included trials.
Main results: Six trials contributed to this review (308 subjects). Pooled data from two trials involving 114 patients did not show any signifi cant improvement in the chance of a 50% increase in hearing threshold on Pure Tone Average (PTA) when HBOT was used (relative risk [RR] with HBOT 1.53, 95% CI 0.85 to 2.78, P = 0.16), but did show a signifi cantly increased chance of a 25% increase in PTA (RR 1.39, 95% CI 1.05 to 1.84, P = 0.02). There was a 22% greater chance of improvement with HBOT, and the number needed to treat (NNT) to achieve one extra good outcome was fi ve (95% CI 3 to 20). A single trial involving 50 subjects also suggested signifi cantly more improvement in the mean PTA threshold with HBOT, expressed as a percentage of baseline (WMD 37%, 95% CI 22% to 53%, P < 0.001). The significance of any improvement following HBOT in a subjective rating of tinnitus could not be assessed due to poor reporting. There were no signifi cant improvements in hearing or tinnitus reported in the single study to examine chronic presentation (six months) of ISSHL and/or tinnitus.
Authors' conclusion: For people with early presentation of ISSHL, the application of HBOT significantly improved hearing loss, but the clinical signifi cance of the level of improvement is not clear. We could not assess the effect of HBOT on tinnitus by pooled data analysis. The routine application of HBOT to these patients cannot be justifi ed from this review. In view of the modest number of patients, methodological shortcomings and poor reporting, this result should be interpreted cautiously, and an appropriately powered trial of high methodological rigour is justifi ed to defi ne those patients (if any) who can be expected to derive most benefi t from HBOT.There is no evidence of a benefi cial effect of HBOT on chronic presentation of ISSHL and/or tinnitus and we do not recommend use of HBOT for this purpose based on the single study available.

Hyperbaric oxygen in tinnitus: influence of psychological factors on treatment results?
ORL J Otorhinolaryngol Relat Spec. 2007;69(2):107-12.
Porubsky C, Stiegler P, Matzi V, Lipp C, Kontaxis A, Klemen H, Walch C, Smolle-Juttner F
Division of Thoracic Surgery and Hyperbaric Medicine, University of Medicine, Graz, Austria. christian.porubsky@klinikum-graz.at
Introduction: The standard treatment of subjective tinnitus hardly reaches the level of placebo controls. Though the effectiveness of hyperbaric oxygenation (HBO) for subjective tinnitus has never been objective defied, it is still advocated by some institutions. We analyzed the effectiveness of hyperbaric oxygen treatment in the context of accompanying factors.
Patients and methods: We randomized 360 patients suffering from tinnitus into 2 HBO treatment protocols (group A: 2.2 bar for 60 min bottom time and group B: 2.5 bar for 60 min bottom time once a day for 15 days). All patients were asked to fi ll in a questionnaire (social and medical history, tinnitus characteristics, pre-HBO duration of tinnitus, prior therapy, pretreatment expectation, accompanying symptoms). A subjective assessment of the therapeutic effect was obtained.
Results: Twelve patients (3.3%) experienced complete remission of tinnitus, in 122 (33.9) the intensitylessened, and 44 (12.2%) had a subjectively agreeable change of noise characteristics. No change was found in 157 cases (43.6%) and 25 (6.9%) experienced deterioration. There was no statistically significant difference between groups A and B (p > 0.05). Out of 68 patients with a positive expectation of HBO effects, 60.3% stated that the tinnitus had improved whereas only 47.2 and 19%, respectively, out of patients who underwent therapy with an indifferent (n = 271) or negative expectation (n = 21) reported an improvement. The infl uence of subjective expectation on the outcome was statistically signifi cant (p <0.05).
Conclusion: The therapeutic effects of HBO on subjective tinnitus may be substantially infl uenced by psychological mechanisms.

A (back to top)

ADANO (Arbeitsgemeinschaft deutschsprachiger Audiologen und Neurootologen). Empfehlung der ADANO vom 14. März 1998 zur Retraining-Therapie. Hörakustik 1998a; 8: 54-55.

ADANO. Empfehlung der ADANO vom 14. März 1998 zur Retraining-Therapie. audio-telegramm 1998b; 6: 1-2.

ADANO. Empfehlung der ADANO vom 14. März 1998 zur Retraining-Therapie. HNO aktuell 1998c; 6: 141-142.

Ahrens S. Die psychosomatische Betrachtungsweise. In: Ahrens et al, eds. Psychosomatik in der Neurologie. Stuttgart: Schattauer, 1995: 3-9.

Akioka K. Pathohistological study on active endolymphatic hydrops in guinea pig with stress stimulations. Nippon-Jibiinkoka-Gakkai-Kaiho 1990; 93: 1250-1257.

Alberti PW. Tinnitus in occupational hearing loss: nosological aspects. J Otolaryngol 1987; 16 (1): 34-35.

Almeling M, Hesse G, Tomkiewicz W, Weslau W. Hyperbaric oxygen therapy in sudden deafness and acute tinnitus. In: Reich G, Vernon JA, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland

American Tinnitus Association 1996: 473-476.

Alster J, Shemesh Z, Ornan M, Attias J. Sleep disturbance associated with chronic tinnitus. Biological Psychiatry 1993; 34: 84-90.

Altrock T. Tinnitus: ganzheitlich behandelt mit Homöopathie und Akupunktur. Heidelberg: Haug, 1993. Ambrosino SV. Neuropsychiatric aspects of tinnitus. J Laryngol Otol 1981; suppl 4: 169-172.

American Tinnitus Association (ATA). Results of the 1992 tinnitus patient survey. Poster presented at the Third International Congress of Behavioral Medicine, Amsterdam, 1994. Portland: ATA, 1994.

Andersson G, Melin L, Scott B, Lindberg P. Dispositional optimism and coping with hearing impairment. Poster presented at the third International Congress of Behavioral Medicine, Amsterdam, 1994a.

Andersson G, Melin L, Scott B, Lindberg P. Behavioral counselling for subjects with aquired hearing loss. A new approach to hearing tactics. Scand Audiol 1994b; 23: 249-256.

Andersson G. Hearing as behaviour. Psychological aspects of aquired hearing impairment in the Elderly. Doctoral dissertation at Faculty of Social Sciences, Uppsala University. Uppsala: Reprocentralen HSC, 1995.

Andersson G, Melin L, Hägnebö C, Scott B, Lindberg P. A review of psychological treatment approaches for patients suffering from tinnitus. Annals of Behavioral Medicine 1995a; 17: 357-366.

Andersson G, Melin L, Lindberg P, Scott B. Development of a short scale for self-assessment of experiences of hearing loss. The hearing coping assessment. Scand Audiol 1995b; 24: 147-154.

Andersson G, Melin L, Scott B, Lindberg P. An evaluation of behavioural treatment approach to hearing impairment. Behav Res Ther 1995c; 33: 283-292. Scand Audiol 24: 147-154.

Andersson G, Melin L, Scott B, Lindberg P. Dispositional optimism, dysphoria, health and coping with hearing impairment in elderly adults. Audiology 1995 d; 34: 76-84.

Andersson G, Melin L, Scott B, Lindberg P. A two-year follow-up examination of a behavioral treatment approach to hearing tactics. Br J Audiol 1995e; 29: 283-292.

Andersson G, Lyttkens L. Acupuncture for tinnitus: time to stop? Scand Audiol 1996; 25: 273-275. Andersson G. Prior treatments in a group of tinnitus sufferers seeking treatment. Psychother Psychosom 1997a; 66: 107-110.

Andersson G. Cognitive-behavioural treatment for tinnitus: a difficult case. Scand J Behav Ther 1997b; 26: 86-92. Andersson G, McKenna L. Contributions of clinical psychology in audiology: Hearing impairment and tinnitus. Clin Psychol Psychother 1997; 4: 42-50.

Andersson G, Lyttkens L. A meta-analytic review of psychological treatments for tinnitus. Br J Audiol 1999a; 33: 201-210.

Andersson G, Lyttkens L. Effects of psychological treatment for tinnitus: A metaanalytic review. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999b: 125-127.

Angermeyer C. "Zuviel Streß!" Vorstellungen von Patienten mit funktionellen Psychosen über die Ursachen ihrer Krankheit. In: Flick U, ed. Alltagswissen über Gesundheit und Krankheit: subjektive Theorien und soziale Repräsentationen. Heidelberg: Asanger, 1991.

Anonymus. In: Evered D, Lawrenson G, eds. Tinnitus. Ciba Foundation Symposium 85. London: Pitman Medical Books, 1981: 300-302.

APA (American Psychiatric Association). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed (DSM-III). Washington DC: APA, 1980.

APA (American Psychiatric Association). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, revised (DSM-III-R). Washington DC: APA, 1987.

APA (American Psychiatric Association). Diagnostic and Statistical Manual of Mental Disorders (DSM IV). Washington DC: APA, 1994.

Aran JM, Cazals Y. Electrical suppression of tinnitus. In: Evered D, Lawrenson G, eds. Tinnitus. Ciba Foundation Symposium 85. London: Pitman Medical Books, 1981: 217-225.

Arien A. Die röntgenologische Funktionsdiagnostik der Halswirbelsäule. Orthop. ihre Grenzgeb. 1981; 119: 557-582.

Arlinger S. Tinnitus epidemiology in Sweden. A multicenter study. In: Second Tinnitus Seminar, Uppsala. Swedish Council for planning and Coordination of Research, 1983.

Arnold W. Anmerkungen zur Differentialdiagnose des Tinnitus. Otorhinolaryngol Nova 1995; 5: 112-116. Arnold W, Bartenstein P, Oestreicher E, Römer W, Schwaiger M. Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: A PET study with (18 F) Deoxyglucose. ORL 1996; 58: 195-199.

Arnold W, Ganzer U, eds. Checklisten in der aktuellen Medizin: HNO-Heilkunde. Stuttgart: Thieme, 1997a. Arnold W, Ganzer U. Leitsymptome Ohrgeräusch. In: Arnold W, Ganzer U, eds. Checklisten in der aktuellen Medizin: HNO-Heilkunde. Stuttgart: Thieme, 1997b: 74.

Aronoff GM, Wayne OE. The prediction of treatment at a multidisciplinary pain center. Pain 1982; 14: 67-73.

Arznei-telegramm. Akuter Hörsturz und chronischer Tinnitus: Was ist gesichert? arznei-telegramm 1997; 8: 83-85.

Atkinson JH, Kremer E, Ignelzi RJ. Diffusion of pain language with affective disturbance confounds differential diagnosis. Pain 1982; 12; 375-384.

Attias J, Shemesh Z, Shoham C, Shahar A, Sohmer H. Efficacy of self-hypnosis for tinnitus relief. Scand Audiol 1990; 19: 245-249.

Attias J, Shemesh Z, Sohmer H, Gold, S, Shoham C, Faraggi D. Comparison between self-hypnosis, masking and attentiveness for alleviation of chronic tinnitus. Audiology 1993; 32: 205-212.

Attias J, Shemesh Z, Bleich A, et al. Psychological profile of help-seeking and non-help-seeking tinnitus patients. Scand Audiol 1995; 24: 13-18.

Aubry M, Pialoux P, Narcy P, Fontelle P. Sindrome cervicale posttraumatique. Recenti Prog Med 1968; 45: 422.

Axelsson A, Sandh A. Tinnitus in noise induced hearing loss. Br J Audiol 1985; 19: 271-276.

Axelsson A, Ringdahl A. Tinnitus - a study of its prevalence and characteristics. Br J Audiol 1989; 23: 53-62.

Axelsson A. Causes of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992a: 275-277.

Axelsson A. How to evaluate treatment for tinnitus; conclusion. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992b: 569-571.

Axelsson A, Coles R, Erlandsson S, Lenarz T, Meikle M, Tayl er R. Evaluation of tinnitus treatments. Introductions. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992; 543-544.

Axelsson A, Andersson S, Gu LD. Acupuncture in the management of tinnitus: a placebo-controlled study. Audiology 1994; 33: 351-360.

Axelsson A. How severe is his tinnitus and what is its prognosis? In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar. Portland: American Tinnitus Association, 1995a: 363-366.

Axelsson A. Tinnitus epidemiology. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar. Portland: American Tinnitus Association, 1995b.

Axelsson A, Andersson S, Gu LD. Acupuncture in the management of tinnitus: a placebo-controlled study. In: Reich G, Vernon J, eds. Proceedings of the fifth International Tinnitus Seminar. Portland: American Tinnitus Association, 1995: 71-73.

Azrin NH. A strategy for applied research. American Psychologist 1977; 32: 140-149. Bandler R, Grinder J. Neue Wege der Kurzzeit-Therapie. Neurolinguistische Programme. Paderborn: Junfermann, 1984.

B (back to top)

Bandler R. Veränderung des subjektiven Erlebens: Fortgeschrittene Methoden des NLP. Paderborn: Junfermann, 1987.

Bandura A. Self-efficacy: Toward a unifying theory of behavioral change. Psychol Rev 1977; 84: 191-215.

Barnea G, Attias J, Gold S, Shahar A. Tinnitus with normal hearing sensitivity: Extended high-frequency audiometry and auditory-nerve brain-stem-evoked responses. Audiology 1990; 29: 36-45.

Baskill JL, Coles RRA, Lutman ME, Axelsson A. Tinnitus severity gradings: longitudinal studies. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992: 457-459.

Bayer E. Tinnitus bedeutet "offene" Otoplastik. Hörakustik 1996; 6: 11.

Beausang-Linder M, Hultcrantz E. Early effects of cervical stimulation on cerebral, ocular and cochlear blood flow. Acta Physiol Scand 1980; 109: 433-437.

Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571.

Beck AT. Depression: clinical, experimental and theoretical aspects. New York: Harper & Row, 1967.

Beck AT. Cognitive therapy; nature and relation to behavior therapy. Behavior Therapy 1970; 1: 184-200. Beck AT. Cognitive therapy and the emotional disorders. Madison CT: International University Press, 1976.

Beck AT. Wahrnehmung der Wirklichkeit und Neurose. München: Pfeiffer, 1979. Beck AT. Cognitive therapy and the emotional disorders. New York: International University Press, 1996.

Bereiter C. Some persisting dilemmas in the measurement of change. In: Harris CW, ed. Problems in measuring change. Madison: University of Wisconsin Press, 1963: 3.

Bernstein DA, Borkovec TD. Progressive relaxation training: a manual for the helping professions. Champaign, II, Research Press, 1973.

Bernstein DA, Borcovec TD. Entspannungs-Training. München: Pfeiffer, 1975. Berrios GE, Ryley JP, Garvey TPN, Moffat DA. Psychiatric morbidity in subjects with inner ear disease. Clin Otolaryngol 1988; 13: 259-266.

Besser-Siegmund C. Die sanfte Schmerztherapie mit mentalen Methoden. Stuttgart: Econ, 1989.

Biesinger E. Funktionelle Störungen der Halswirbelsäule in ihrer Bedeutung für die Hals-Nasen-Ohren-Heilkunde. In: Ganz H, Schätzle W, eds. HNO Praxis Heute. Berlin, Heidelberg, New York: Springer, 1989.

Biesinger E. Krankengymnastik und Hals-Nasen-Ohren- Heilkunde: Von der Halswirbelsäule beeinflußte Krankheitsbilder in der Hals-Nasen-Ohren-Heilkunde. Z Krankengymnastik 1988; 11: 923-935.

Biesinger E. Der chronische Tinnitus im Zusammenhang mit funktionellen Störungen der Halswirbelsäule. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 271-284.

Biesinger E. Vertebrolabyrinthäre Erkrankungen. In: Zenner HP, ed. Praktische Therapie von Hals-Nasen-Ohren- Krankheiten. Stuttgart: Schattauer, 1993a: 132-135.

Biesinger E. Chirotherapeutische Faktoren bei Erkrankungen in der HNO-Heilkunde. Teil 1: Anatomie, Physiologie. HNO aktuell 1993b; 1: 299-304.

Biesinger E. Chirotherapeutische Faktoren bei Erkrankungen in der HNO-Heilkunde. Teil 2: Vertebragene Krankheitsbilder, Therapie. HNO aktuell 1993c; 1: 347-351.

Biesinger E. Einsatzmöglichkeiten der Manualtherapie im Fachgebiet - das C2-C3-Syndrom. Euro Arch Otorhinolaryngol 1994; Suppl II. Biesinger E, Heiden C. Ohrschmerz und Funktionsstörungen der Halswirbelsäule. HNO 1994; 42: 207-213.

Biesinger E. Persönliche Mitteilungen über erste Ergebnisse zur Retraining-Therapie. (1996a)

Biesinger E. Die Behandlung von Ohrgeräuschen. Tinnitusmasker und Trainingstherapie (Retraining). Stuttgart: Trias, 1996b: 78-91.

Biesinger E. Das C2/ C3-Syndrom: Der Einfluß zervikaler Afferenzen auf HNO-ärztliche Krankheitsbilder. Manuelle Medizin 1997a; 35: 12-19.

Biesinger E. Ambulante Tinnitustherapie. Arbeitsgemeinschaft deutschsprachiger Audiologen und Neurootologen ADANO. Arbeitstagung 20.-22.3. 1997. (1997b)

Biesinger E. Qualifizierung zur Retrainingtherapie: Bevormundung oder Schutz? HNO-Mitteilungen 1998; 48: 144-145.

Biesinger E, Greimel V. Ergebnisse der Tinnitus-Retraining- Therapie (TRT). Tinnitus-Forum 1998; 1: 7-8.

Biesinger E, Heiden C, Greimel V, Lendle T, Höning R, Albegger K. Strategien in der ambulanten Behandlung des Tinnitus. HNO 1998; 2: 157-169.

Biesinger E, Heiden C. Die Bedeutung der Retrainingtherapie bei Tinnitus. Dt Ärztebl 1999; 96: A 2817-2825.

Biesinger, E. (2001) Tinnitus und Störungen der Halswirbelsäule. In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München: 279-292

Binder H, Binder K. Autogenes Training - Basispsychotherapeutikum. Köln: Deutscher Ärzte-Verlag, 1989.

Black S, Wigan ER. An investigation of selective deafness produced by direct suggestion under hypnosis. Br Med J 1969, 2: 736-741.

Blumenbach L. Menière's Originalarbeiten. Göttingen: Musterschmidt, 1955.

Boenninghaus HG. Hals-Nasen-Ohrenheilkunde. Berlin, Heidelberg, New York: Springer, 1996.

Borner A. Epidemiologische Untersuchungen über die Ätiologiefaktoren dysfunktioneller Erkrankungen im stomatognathen System. Med. Diss. Basel, 1987.

Borton TE, Moore, WM, Clark SR. Electromyographic feedback treatment for tinnitus aurium. J Speech Hear Disord 1981; 4: 39-45.

Brandt T. Schwindel: Die häufigsten Formen. Internist 1995; 36: 1105-1113.

Brattberg G. An alternative method of treating tinnitus: Relaxation-hypnotherapy primarily through the home use of a recorded audio cassette. Int J Clin Exp Hypn 1983; 31: 90-97.

Brengelmann JC. Psychologische Aufgaben bei der Integration der Behinderten. In: Berufsverband Deutscher Psychologen, ed. Psychologische Hilfen für Behinderte, Band 1. Weinsberg: Weissenhof, 1985: 27-36.

Bridges KW, Goldberg DP. Somatic presentation of DSM-II psychiatric disorders in primary care. J Psychosom Res 1985, 29: 563-569.

Briner W. A behavioral nosology for tinnitus. Psychol Rep 1995; 77: 27-34.

Brinkmann U. Ärztlicher Fragebogen der Deutschen Tinnitus-Liga. 71. Jahrestagung der Norddeutschen Vereinigung der HNO-Ärzte. Hameln, 1988.

Brinkmann U. Zum Arzt-Patienten-Verhältnis. Tinnitus- Forum 1992; 3: 4-8.

Brooks DN, Bulmer D. Survey of binaural hearing aid users. Ear Hear 1981; 2: 220-224.

Brügel FJ, Schorn K. Zervikaler Tinnitus nach HWS-Behandlung. Laryngorhinootol 1991; 70: 321-325.

Brügger A. Die Erkrankungen des Bewegungsapparates und seines Nervensystems. Stuttgart: Fischer, 1979.

Brummet R. A mechanism for tinnitus? In: Vernon JA, Møller AR, eds. Mechanisms of tinnitus. Boston: Allyn and Bacon, 1995: 7-10.

Brusis J. Begutachtung der akuten Schallempfindungsschwerhörigkeit. 94. Tagung der Vereinigung Westdeutscher HNO-Ärzte, Münster. Zentralbl HNO, Plastische Chirurgie Kopf und Hals 1990; 1.

Boenninghaus H. Der idiopathische Hörsturz. Dt Ärztebl 1988; 85: 2215-2217.

Bond J, Tyler P. Validation of the Tinnitus Questionnaire. Unpublished manuscript. University of Birmingham, UK, 1994.

BTA. Up-date on the management of tinnitus by audiologists. Prepared by the Clinical Guidelines Working Group of the British Tinnitus Association (March 1999).

BTA,White Building, 4th Floor, Fitzalan Square, GB-Sheffield SI 2AZ. Budd RJ, Pugh R. The relationship between locus of control, tinnitus severity, and emotional distress in a group of tinnitus sufferers. J Psychosom Res 1995; 39: 1015-1018.

Budd RJ, Pugh R. Tinnitus coping style and its relationship to tinnitus severity and emotional distress. J Psychosom Res 1996; 41: 327-335.

Buller R, Benkert O. Panikattacken und Panikstörung. Diagnose, Validierung und Therapie. Nervenarzt 1990; 61: 647-657.

Bumann A, Kopp S, Ewers R. Das Kompressionsgelenk als Differentialdiagnose bei chronischen Gesichtsschmerzen. Dtsch Zahnärztl Z 1989; 12: 962-963.

C (back to top)

de Camp U. Beeinflußung des Tinnitus durch psychologische Methoden. Diplomarbeit, Psychologisches Institut der FU Berlin, 1989.

de Camp-Schmidt E, de Camp U. Tinnitusbewältigung durch Streßimmunisierung. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 165-178.

Campbell NR. Symposium: Measurememt and its importance for philosophy. Aristotelian Soc 1938; 17: Suppl.

Canlon Barbara, Pharmacological strategies for prevention and treatment of hearing loss and tinnitus.
Hear Res. 2007 Apr;226(1-2):1-2. Epub 2007 Feb 28. Editorial
Barbara Canlon1, Guest Editors, Donald Henderson and Richard Salvi2 1Karolinska Institutet, Sweden, 2State University of New York at Buffalo, USA. (Sample of the text)

Carlin R, McGraw DJ, Anderson CB. Objective tinnitus from internal carotid artery stenosis. J Vasc Surg 1997; 25: 581-583.

Carmen R, Svihovec D. Relaxation biofeedback in the treatment of tinnitus. Am J Otolaryngol 1984; 5: 376-381.

Ceylan A, Celenk F, Kemaloglu YKBayazit YAGoksu N
Impact of prognostic factors on recovery from sudden hearing loss.
J Laryngol Otol. 2007 Jan 23;:1-6 [Epub ahead of print]
Ozbi Dot Above Len S Department of Otolaryngology, Gazi University School of Medicine, Ankara, Turkey. (Sample of the text)

Chung DY, Cannon RP, Mason K. Factors affecting the prevalence of tinnitus. Audiology 1984; 23: 441-452.

CIPS-Collegium Internationale Psychiatrie Scalarum, ed. Internationale Skalen für Psychiatrie - Symptom Check List 90-R (SCL-90-R). Weinheim: Beltz Test Gesellschaft, 1989.

Clark DM. Applied relaxation. A new look at an old technique. Scand J Behav Ther 1988; 17: 79-82. 338

Claussen E, Claussen CF. Funktionelle Hörbahnveränderungen bei Tinnitus. Arch Klin exper Ohr-Nasen-Kehlkopfheilkunde 1986; Suppl 2: 64-67.

Clemis JD, McBrien MM. The therapeutic use of histamine in cochleovestibular disorders and tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 203-209.

Cochrane GL. Clienttherapist collaboration in the preparation of hypnosis interventions: Case illustrations. Am J Clin Hypn 1991; 33: 254-260.

Coker NJ, Coker RR, Jenkins AH, Vincent KR. Psychological profile of patients with Menière's disease. Arch Otolaryngol Head Neck Surg 1989; 11: 1355-1357.

Coles RRA, Davis AC, Haggard MP. Epidemiology of tinnitus. In: Evered D, Lawrenson G, eds. Tinnitus. Ciba Foundation Symposium 85. London: Pitman Medical Books, 1981: 16-26.

Coles RRA. Epidemiology of tinnitus: 1. Prevalence. J Laryngol Otol 1984a; 98, Suppl 9: 7-15.

Coles RRA. Epidemiology of tinnitus: 1. Demographic and clinical feature. J Laryngol Otol 1984b; 98, Suppl 9: 195-202.

Coles RRA, Hallam RS. Tinnitus and its management. Br Med Bull 1987; 43( 4): 983-998.

Coles RRA. Hyperacusis and phonophobia in tinnitus patients. Br J Audiol 1988; 22: 228.

Coles RRA, Bradley P, Donaldson I, Dingle A. A trial of tinnitus therapy with earcanal magnets. Clin Otolaryngol 1991; 16: 371-372.

Coles RRA, Lutman ME, Axelsson A, Hazell JWP. Tinnitus severity gradings: crosssectional studies. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux,Amsterdam, New York: Kugler, 1992: 453-456.

Coles R. Classification of causes, mechanisms of patient disturbance, and associated counseling. In: Vernon JA, Møller AR, eds. Mechanisms of tinnitus. Boston, London, Toronto: Allyn and Bacon, 1992: 11-20.

Coles RRA. Compensable tinnitus from causes other than noise. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 135-141.

Coles RRA, Baskill JL. Absolute loudness of tinnitus: tinnitus clinic data. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 135-141.

Collet L, Moussu MF, Disant F, Ahami T, Morgon A. Minnesota Mutiphasic Personality Inventory (MMPI) in tinnitus disorders. Audiology 1990; 29: 101-106.

Cohen J. Statistical power analysis for the behavioral sciences. New York: Academic Press, 1992.

Cohen H, Ewell LR, Jenkins HA. Disability in Menière's Disease. Arch Otolaryngol Head Neck Surg 1995; 121: 29-33.

Costen JB. A syndrome of ear and sinus symptoms dependent upon disturbed function of the temporomandibular joint. Ann Otol Rhinol 1934; 43: 1.

Crasilneck HB, Hall JA. Clinical hypnosis, principles and applications. New York: Grune & Stratton, 1975.

Crawford HJ. Enhanced visual memory during hypnosis as mediated by hypnotic responsiveness and cognitive strategies. J Exp Psychol 1983; 112: 662-665.

Creed F, Firth D, Timol M, Metcalfe R, Pollock S. Somatization and illness behaviour in a neurology ward. J Psychosom Res 1990; 34: 427-437.

Crown S, Crisp AH. Manual of the Crown-Crisp Experiential Index. London: Hodder and Stoughton, 1979.

Czubalski W, et al. Psychological stress and personality in Menières Disorder. J Psychosom Res 1976; 20: 187-91.

D (back to top)

Dämming I, Rechenberger HD. Ergebnisse eines Katamneseprogramms. Praxis Psychother Psychosom 26: 127-137.

Danino J, Joachims HZ, Eliacher I, et al. Tinnitus as a prognostic factor in sudden deafness. Am J Otolaryngol 1984; 5: 394-396.

Dauman R, Tyler RS. Some considerations on the classification of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1995: 225-229.

Davidson HC, Lutman ME - Survey of mobile phone use and their chronic effects on the hearing of a student population.
[Article in English, French] Int J Audiol. 2007 Mar;46(3):113-118.
Institute of Sound and Vibration Research, University of Southampton. Southampton. UK.
(Sample of the text)

Davies S, McKenna L, Hallam RS. Relaxation and cognitive therapy: a controlled trial in chronic tinnitus. Psychology and Health 1995; 10: 129-143.

Davies PB, Wilde RA. Clinical trial of a new tinnitus masking technique. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 405-309.

Davis AC. The prevalence of hearing impairment and reported hearing disability among adults in Great Britain. Int J Epidemiol 1989; 18(4): 911-917.

DeBoever JA. Functional disturbances of the temporomandibular joint. In: Zarb GA, Carlsson GE, eds. Temporomandibular joint - function and dysfunction. Kopenhagen: Munksgaard, 1979: 193-214.

Decher H. Die zervikalen Syndrome in der Hals-Nasen- Ohren-Heilkunde. Stuttgart: Thieme, 1969.

Degkwitz R, Helmchen H, Kockott G, Momhour W. Diagnoseschlüssel und Glossar psychiatrischer Krankheiten. Deutsche Ausgabe der Internationalen Klassifikation der Kankheiten der WHO, ICD-9. Revision. Berlin: Springer, 1980.

Deneke H, Glier B, Klinger R, Kröner-Herwig B, Nilges P, Redegeld M, Weiß L. Qualitätssicherung in der Therapie chronischen Schmerzes. X. Instrumente zur Erfassung von Schmerzen bei Kindern. Schmerz 1996; 11: 120-125.

Desloovere C, Meyer-Breiting E, Iberg C von. Randomisierte Doppelblindstudie zur Hörsturztherapie: erste Ergebnisse. HNO 1988; 36: 417-422.

Derogatis LR.The SCL-90-R. Administration, Scoring and Procedures Manual. Baltimore: Clinical Psychometrics Research, 1977.

Derogatis LR. Symptom-Check-List. 3rd ed. Weinheim: Beltz, 1986.

Deutsche Tinnitus-Liga. Tinnitus ist eine Volkskrankheit. Tinnitus-Forum 1999; Aug: 58-60.

Devor M. Central changes mediating neuropathic pain. In: Dubner R, Gebart GF, Bond MR, eds. Proceedings of the Fifth World Congress on Pain. Amsterdam: Elsevier, 1988: 114-128.

Deyo RA, Diehl AK. Psychosocial preditors of disability in patients with low back pain. J Reumatol 1988; 15: 1557.

Dobie RA, Hobverg KE, Rees TS. Electrical tinnitus suppression: A doubleblind crossover study. Otolaryngol Head Neck Surg 1986; 95: 319-323.

Dobie RA, Sullivan M, Katon WJ, Sakai CS. Russo J. Antidepressant treatment of tinnitus patients. Acta Otolaryngol 1992; 112: 242-247.

Domachevsky L, Keynan Y, Shupak A, Adir Y - Hyperbaric oxygen in the treatment of sudden deafness.
Eur Arch Otorhinolaryngol. 2007 Mar 15; [Epub ahead of print]
Israel Naval Medical Institute, IDF Medical Corps, P.O. Box 8040, 31 080, Haifa, Israel, liranura@bezeqint.net. (Sample of the text)

Domnick L. Über die Beziehungen der Halswirbelsäule zu Hals-, Nasen-, Ohrenerkrankungen. Erfahrungsheilkd 1965; 14: 585.

Douek E. Electrical stimulation of the inner ear - auditory; tinnitus suppression results and speech discrimination. Proceedings of the Second International Tinnitus Seminar 1983. J Laryng Otol 1987; Suppl 9: 137-138.

Douek E. Tinnitus following surgery. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1987: 64-69.

Domenech J, Fusté J, Trassera G, Trassera J. High frequency audiometry in the clinical evaluation of tinnitus patients. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 49-51.

Drachman DA, Hart CW. An approach to the dizzy patient. Neurology 1982; 22: 323-330.

Drescher DG, Drescher MJ. Calcium and magnesium dependence of spontaneous and evoked afferent neural activity in the lateral-line organ of xenopus laevis. Comparative Biochemistry and Physiology 1987; 87: 305-310.

Drum W. Zahnmedizin für Ärzte. Berlin: Quintessenz, 1972.

DuBrul EL. Embryological development of the temporomandibular joint. In: Sarnat BG, ed. The temporomandibular joint. Springfield: Thomas, 1964.

Duckro PN, Pollard CA, Bray HD, Scheiter L. Comprehensive behavioral management of complex tinnitus: a case illustration. Biofeedback and Selfregulation 1984; 9: 459-469.

Dulon D, Aran JM, Schacht J. Osmotically induced motility of outer hair cells: implications for Menière's Disease. Arch Oto Rhino Laryngol 1987; 244: 104-107.

Dzeik R, Pieper U, Stange G. Unsere Erfahrungen mit Tinnitus-Maskern. Audiol Akustik 1981; 84-95.

E (back to top)

East CA, Hazell JWP. The suppression of palatal (or intratympanic) myoclonus by tinnitus masking devices. J Laryng Otol 19887; 101: 1230-1234.

Eckhardt A, et al. Schwindel und Angsterkrankungen - Ergebnisse einer interdisziplinären Untersuchung. Laryngorhinootologie 1996; 75: 517-522.

Eckhardt-Henn A. Der phobische Schwankschwindel, eine weitere Differenzierung psychogener Schwindelzustände scheint erforderlich. Nervenarzt 1997a; 68: 806-812.

Eckhardt-Henn A, et al. Krankheitsspezifische Kontrollüberzeugungen bei Patienten mit der Leitsymptomatik Schwindel. Psychother Psychosom Med Psychol 1997b; 47: 403-409.

Eggermont JJ. On the pathophysiology of tinnitus: A review and a peripheral model. Hear Res 1990; 48: 111-124.

Egle UT, Göbel H, Graf-Baumann T, Zenz M. Entspannungsverfahren bei chronischen Schmerzpatienten. Schmerz 1997; 4: 282-295.

Ehman G. Problem der Ohrgeräusche bei der Lärmschwerhörigkeit. Dissertation. Universität Jena, 1965.

Ehrenberger K, Denk DM, Felix D. Rezeptorpharmakologische Modelle für eine kausale Tinnitustherapie. Otorhinolaryngol Nova 1995; 5: 148-152.

Eitner J. Zur Psychologie und Soziologie Hörbehinderter. Heidelberg: Median, 1996. 333-379_Literatur.qxd 13.09.2001 12:56 Uhr Seite 340o341

Eklund M. Chronic pain and vocational rehabilitation: a multifactorial analysis of symptoms, signs and psychosocio demographics. J Occup Rehabilitation 1992; 2: 53.

Elfner LF, May JG, Moore JD, Mendelson JM. Effects of EMG and thermal feedback training on tinnitus: a case study. Biofeedback Self Regul 1981; 6: 517-521.

Elies W. Zum Stellenwert immunologischer Befunde und der Rundfensterruptur im Ursachenspektrum cochleo-vestibulärer Symptome. HNO-Informationen 1992; 4: 8-17.

Ellis A. Die rational-emotive Therapie RET. München: Pfeiffer, 1977.

Ellis A. The use of hypnosis with rational-emotive Therapie (RET). Int J Ecclectric Psychother 3: 15-22.

Ellgring H, Rabaioli-Fischer B. Training of coping strategies for Parkinson patients. Poster for the Behavior Therapy World Congress, Edinburgh, Sept. 5th-10th, 1988.

Ellgring H, Rabaioli-Fischer B. Psychological interventions for Parkinson-Patients. First International Congress of Behavioral Medicine, Uppsala, Sweden, June 27th-30th, 1990.

Erickson MH. The interspersal hypnotic technique for symptom correction and pain control. Am J Clin Hypn 1966; 8: 198-209.

Erickson MH, Rossi EL. Hypnotherapie: Aufbau - Beispiele - Forschungen. München: Pfeiffer, 1981.

Eriksson-Mangold M, Carlsson SG. Psychological and somatic distress in relation to perceived hearing disability, hearing handicap and hearing measurements. J Psychosom Res 1991; 6: 729-740.

Erlandsson S, Rubinstein B, Carlsson SG, Ringdahl A. Biofeedback and stomatognathic treatment. A prospective study of tinnitus patients. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar Münster. Karlsruhe: Harsch, 1987: 389-392.

Erlandsson S, Ringdahl A, Hutchins T, Carlsson SG. Treatment of tinnitus: a controlled comparison of masking and placebo. Br J Audiol 1987; 21 (1): 37-44.

Erlandsson SI, Carlson SD, Svensson A. Biofeedback in the treatment of tinnitus: A broadened approach. Göteborg Psychol Rep 1989; 19: 1-12.

Erlandsson SI, Ringdahl A, Hutchins T, Carlson SD. Treatment of tinnitus: a controlled comparison of masking and placebo. Br J Audiol 1990; 21: 37-44.

Erlandsson SI, Rubinstein B, Carlsson SG. Tinnitus: Evaluation of biofeedback and stomatognathic treatment. Br J Audiol 1991a; 25: 151-161.

Erlandsson SI, Rubinstein B, Axelsson A, Carlsson SG. Psychological dimensions in patients with disabling tinnitus and craniomandibular disorders (CMD). Br J Audiol 1991b; 25: 15-24.

Erlandsson SI. Assessments of tinnitus, a review. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux.Amsterdam, New York: Kugler, 1992: 545-549.

Erlandsson S, Rubinstein B. Tinnitus: psychological and stomatognathic aspects and treatment evaluation. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux.Amsterdam, New York: Kugler, 1992: 481-483.

Erlandsson SI, Hallberg LRM, Axelsson A. Psychological and audiological correlates of perceived tinnitus severity. Audiology 1992; 31: 168-179.

Erlandsson S, Persson ML. Clinical implications of tinnitus and affective disorders. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 557-562.

Eysenck H, Eysenck S. Manual of the Eysenck personality questionnaire. London: Hodder and Stoughton, 1975.

F (back to top)

Fahrenberg J, Hampel H, Selg H. Das Freiburger Persönlichkeitsinventar (FPI-R). Handanweisung. Göttingen: Hogrefe, 1984.

Federschmidt H. Wirksamkeit und Nutzen von psychotherapeutischen Behandlungsansätzen. Dt Ärztebl 1996; 93: 34-37

Federspil P. Ototoxische Risiken durch Arzneimittel. Dt Ärztebl 1990; 87: B228-B234.

Feinmesser R, Freeman JL. Cervical tinnitus: legend or fact? J Laryngol Otol 1987; 101: 376-380.

Feldenkrais M. Die Entdeckung des Selbstverständlichen. Frankfurt am Main: Suhrkamp, 1987.

Feldmann H. Homolateral and contralateral masking of tinnitus by noisebands and pure tones. Audiology 1971; 10: 138-144.

Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987a.

Feldmann H. Hörsturz-Therapie. Dtsch Med Wochenschr 1987b; 112: 767-768.

Feldmann H. Resignation oder therapeutische Chance bei Tinnitus? Therapiewoche 1989a; 39: 1430-1434.

Feldmann H. Kulturhistorisches und Medizinhistorisches zum Tinnitus aurium. Karslruhe: Harsch, 1989b.

Feldmann H. Tinnitus. Stuttgart: Thieme, 1992a.

Feldmann H. Pathophysiologie des Tinnitus. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1992b: 3-70.

Feldmann H. Spezielle audiologische Diagnostik. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1992c: 84-92.

Feldmann H. Medizinhistorisches und Kulturhistorisches zum Tinnitus. In: Feldmann, H, ed. Tinnitus. Stuttgart: Thieme, 1992d: 1-32.

Feldmann H. Therapie des chronischen Tinnitus. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1992e: 93-100.

Feldmann H. Tinnitus. In: Helms F, ed. Ohr; Band 1. In: Naumann HH, Helms J, Herberhold C, Kastenbauer E, eds. Oto-Rhino-Laryngologie in Klinik und Praxis. Stuttgart: Thieme, 1994: 796-803.

Fengler J. Hörgeschädigte Menschen. Beratung, Therapie und Selbsthilfe. Stuttgart: Kohlhammer, 1990. 342

Feustle G. Hypnotisch induzierte Taubheit. Eine Literaturübersicht der experimentellen Hypnoseforschung über hypnotisch induzierte Taubheit. Exp klin Hypn 1985; 2: 153-165.

Fichter MM, Goebel G. Konzeption einer Verhaltensmedizinischen Behandlung chronischer Schmerzsyndrome. Praxis Psychotherapie und Psychosomatik 1989; 34: 205-213.

Fichter MM. Ver haltenstherapie psychosomatischer Erkrankungen. In: Möller HJ. Therapie psychiatrischer Erkrankungen. Stuttgart: Thieme, 1993: 555-564.

Fichter M, Goebel G. Psychosomatische Aspekte des chronischen komplexen Tinnitus. Dt Ärztebl 1996; 93: A1771-1776 [Heft 26].

Fischer PA. Schwindel: Neurologische Aspekte. Dt Ärztebl 1972; 69: 2533-2537.

Fleischer G. Tinnitus bei Jugendlichen. Internationales Tinnitus-Symposium der Deutschen Tinnitus-Liga anläßlich ihres 10-jährigen Bestehens. Vortrag 5. 6. 1996.

Flor H, Birmaumer N. Comparison of the efficacy of electromyographic biofeedback, cognitive-behavioral therapy and conservative medical interventions in the treatment of chronic musculoskeletal pain. J Consult Clin Psychol 4: 653-658.

Flor H. Kortikale Reorganisation bei Tinnitus: Tinnitusfrequenzdiskrimination. Vortrag 3. Tinnitus-Symposium der HNO-Klinik und -Poliklinik der Charité Berlin, 15.4.2000.

Florin I. Psychische Symptome und Krankheitsanfällignkeit bei schwerhörigen Erwachsenen. Hörakustik 1990; 9: 16-21/64-73.

Fordyce WE. Behavioural methods for chronic pain and illness. St. Louis: Mosby, 1976.

Fowler EP. The "illusion of loudness" of tinnitus: its etiology and treatment. Laryngoscope 1942a; 52: 275-285.

Fowler EP. Control of head noises, their illusions of loudness and timbre. Arch Otolaryngol 1942b: 37: 391-398.

Fowler EP. The emotional factor in tinnitus aurium Laryngoscope 1948; 58: 145-154.

Franke G. Die Symptom-Checkliste von Derogatis, Deutsche Version (SCL-90-R). Göttingen: Beltz, 1995.

Frenzel A, Kröner-Herwig B. Die Behandlung von chronischen Ohrgeräuschen mit psychologisch fundierten Verfahren. In: Kröner-Herwig B, ed. Psychologische Behandlung des chronischen Tinnitus. Weinheim: PVU, 1997: 23-31.

Frenzel A. Chronischer Tinnitus: Evaluation eines kognitiv-behavioralen Gruppentrainings und einer Minimalintervention. Herdecke: GCA, 1998.

Freud S. On the grounds for detaching a particular syndrome from neurasthenia under the description of "anxiety neurosis". In: Standards Edition III. London: Hogarth, 1895.

Freud S. Über die Berechtigung, von der Neurasthenie einen bestimmen Symptomenkomplex als Angstneurose abzutrennen. In: Studienausgabe Bd. 6. Frankfurt: 1972: 25ff.

Frisch H.Programmierte Untersuchung des Bewegungsapparats. 3rd ed. Berlin, Heidelberg, New York: Springer, 1989.

Fromm E. Dissociative and integrative processes in hypnoanalysis. In: Dengrove E, ed. Hypnosis and behaviour therapy. Thomas: Springfield, 1978.

Frommberger U, Hurth-Schmidt S, Dieringer H, Trettenborn B, Buller R, Benkert O. Panikstörung und Schwindel. Zur psychopathologischen Differenzierung zwischen neurologischer und psychiatrischer Erkrankung. Nervenarzt 1993; 64: 377-383.

Fürst G, Brost F, Mauerer J, Mann W, Pelster H. Hyperbare Sauerstofftherapie bei Tinnituspatienten. Otorhinolaryngol Nova 1994; 4: 61-65.

G (back to top)

Gabriels P. Tinnitus and hyperacusis. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 563-567.

Gabriels P. Children with tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996.

Gallon RL. Perception of disability in chronic back pain patients. Pain 1989; 37: 67.

Ganz FJ. Ohrgeräusche. Tinnitus-Sprechstunde. Stuttgart: Thieme, 1986.

Ganzer U, Arnold W. Leitlinien/Algorithmen Ohrgeräusche. Laryngorhinootologie 1996; 75: 511.

Garliner D. Myofunktionelle Therapie in der Praxis. München: Verlag Zahnärztlichmedizinisches Schrifttum, 1982.

Gehring A, Blaser A. Minnesota Mutiphasic Personality Inventory (MMPI). Bern, Stuttgart: Huber, 1982.

Geissner E. Dimensionen der Verarbeitung chronischen Schmerzes - eine Replikationsstudie. Z Klin Psychol Psychopathol Psychother 1992; 40: 20-33.

Geissner G, Jungnitsch G.Psychologie des Schmerzes - Diagnose und Therapie. Weinheim: Psychologische Verlags Union, 1992.

Geissner E, Heuser J, Goebel G, Fichter M. Stationäre verhaltensmedizinische Therapie bei Patienten mit chronischen Schmerzen: Behandlungsansatz und Evaluation. Z Gesundheitspsychol 1996; 4 (2): 152-172.

Gentry WD, ed. Handbook of behavioural medicine. New York: Gouilford Press, 1984.

Gerber A. Kiefergelenke und Zahnokklusion. Dtsch Zahnärztl Z 1971; 26: 119.

Gerber KE, Nehemkis AM, Charter RA, Jones HC. Is tinnitus a psychological disorder? Int J Psychiatry Med 1985-86; 15(1): 81-7.

Gerber WD. HNO-Erkrankungen. In: Miltner W, Birbaumer N, Gerber WD, eds. Verhaltensmedizin. Berlin, Heidelberg, New York: Springer, 1986: 345-349.

Gerber WD. Bruxismus. In: Miltner W, Birbaumer N, Gerber WD, eds. Verhaltensmedizin. Berlin, Heidelberg, New York: Springer, 1986: 345-354.

Gerber WD, Diener HC. Verlaufsprotokolle zur Schmerztherapie: Das Tübinger Schmerztagebuch. Manuskript zum ersten Workshop über "Qualitätssicherung in der Algesiologie". Mainz, 1987.

Gerber WD. Hals-Nasen-Ohrenkrankheiten. In: Wilker FW, Bischoff C, Novak P, eds. Medizinische Psychologie und Medizinische Soziologie. München: Urban & Fischer, 1994: 309-317.

Gerken GM, Solecki JM, Boettcher FA. Temporal integration of electrical stimulation of auditory nuclei in normalhearing and hearingimpaired. Hear Res 1991; 53: 101-112.

Gildstone H, Gildstone P. Personality changes associated with surgically corrected hypoacusis. Audiology 1972; 11: 354-367.

Glaninger J. Der Hörsturz in der Seneszenz. Fortschr Med 1982; 100: 1605-1611.

Glaros A. Incidence of diurnal and nocturnal bruxism. J Prosthet Dent 1981; 45: 545.

Glasgold A, Altmann F. The effect of stapes surgery on tinnitus in otosclerosis. Laryngoscope 1966; 76: 1524-1532.

Goebel G. Tinnitus. In: Hand I, Wittchen HU, eds. Verhaltenstherapie in der Medizin. Berlin, Heidelberg, New York: Springer, 1989a: 207-228.

Goebel G. Verhaltensmedizinisches Behandlungskonzept psychosomatischer Erkrankungen am Beispiel des chronischen Schmerzsyndroms. Ärztezeitschr f Naturh u Reg 1989b; 8: 587-599.

Goebel G, Keeser W, Wildgruber C, Baldhuber L, Faust B, Fichter MM. Die stationäre Verhaltensmedizinische Behandlung chronischer Schmerzen. In: Laireiter A, Mackinger A, eds. Verhaltensmedizin - Gesundheitspsychologie. Bergheim: Mackinger, 1989c: 63-79.

Goebel G, Lederer M, Rief W, Fichter M. Integrative multimodale verhaltensmedizinische Behandlung des komplexen chronischen Tinnitus. (Behandlungsergebnisse und Langzeiteffekt). 61. Kongreß der Deutschen HNO-Gesellschaft 28.-29.5.1990; Würzburg. 344

Goebel G, Keeser W, Fichter M, Rief W. Neue Aspekte des komplexen chronischen Tinnitus. Überprüfung eines multimodalen verhaltensmedizinischen Behandlungskonzepts. Psychother med Psychol 1991a; 41: 115-122.

Goebel G, Keeser W, Fichter M, Rief W. Neue Aspekte des komplexen chronischen Tinnitus. Die verlorene Stille: Auswirkungen und psychotherapeutische Möglichkeiten beim komplexen chronischen Tinnitus. Psychother med Psychol 1991b; 41: 123-133.

Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992a.

Goebel G. Studien zur Wirksamkeit psychologischer Therapien beim komplexen chronischen Tinnitus - eine Übersicht. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992b: 87-102.

Goebel G. Briefe an den Tinnitus. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992c: 219-230.

Goebel G, Hiller W. Psychische Beschwerden bei chronischem Tinnitus: Erprobung und Evaluation des Tinnitus- Fragebogens (TF). Verhaltenstherapie 1992a; 2: 13-22.

Goebel G, Hiller W. Tinnitus-Fragebogen (TF): Evaluation eines psychologischen Meßinstruments. In: Goebel G, ed. Interdisziplinäre Diagnostik und Therapie des komplexen chronischen Tinnitus. II. Priener Tinnitus-Symposium. Düsseldorf: Verlag für Wissenschaft und Fortbildung, 1992b: 5-6.

Goebel G, Hiller W. Erfassung psychologischer Aspekte des chronischen Tinnitus mit Hilfe eines Tinnitus-Fragebogens (TF). 63. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie; 1.6.1992; Garmisch-Partenkirchen. (1992c)

Goebel G, Hiller W, Rief W, Fichter M. Ver haltensmedizinisches Behandlungskonzept beim komplexen chronischen Tinnitus. Therapieevaluation und Langzeiteffekt. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992a: 117-152.

Goebel G, Hiller W, Frühauf K, Fichter M. Effects of inpatient multimodal behavioural treatment on complex chronic tinnitus. A controlled one year follow- up-study. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992b: 465-470.

Goebel G. Psychosomatik und Psychotherapie des komplexen chronischen Tinnitus. Psycho 1993a; 19(7): 447-463.

Goebel G. Wie geht es den Tinnitusbetroffenen? Tinnitus- Forum 1993b; 1: 12-13.

Goebel G. Priener Erfahrungen. Evaluation eines Tinnitus-Selbsthilfegruppenleiter-Seminars mit dem Tinnitus-Fragebogen (TF).Tinnitus-Forum 1993c; 1: 14.

Goebel G, Hiller W. Erfassung psychologischer Aspekte des chronischen Tinnitus mit Hilfe eines Tinnitus-Fragebogens. Archiv für Ohren-, Nasen- und Kehlkopfheilkunde 1993a; Suppl 92/II: 202-203.

Goebel G, Hiller W. Standardisierte Meßmethode des Tinnitus-Schweregrades mit Hilfe eines evaluierten Tinnitus-Fragebogens (TF). 4. Kongreß der Deutschen Gesellschaft für Verhaltensmedizin und Verhaltensmodifikation (DGVM) 25.3. 1993, Bonn (Poster). (1993 b)

Goebel G. Verhaltensmedizinische Diagnostik beim chronischen Tinnitus: Strukturiertes Tinnitus-Interview (STI). HNO aktuell 1994a; 2: 281-288.

Goebel G. Tinnitus - oft ein gemeinsamer Quälgeist bei Betroffenen und Experten. Warum macht der lästige Tinnitus Betroffene zu lästigen Patienten? HNO 1994b; 42: 2-3.

Goebel G. Psychosomatische Betreuung von Tinnituspatienten. 45. Tagung der Münchner Oto-Rhino-Laryngologischen Gesellschaft (Leitung Prof. Arnold) 3. 11.1994. (1994c)

Goebel G, Hiller W. Tinnitus-Fragebogen (TF): Standardinstrument zur Graduierung des Tinnitus-Schweregrades; Ergebnisse einer Multicenterstudie mit dem Tinnitus-Fragebogen (TF). HNO 1994a; 42: 166-172.

Goebel G, Hiller W. Verhaltensmedizinische Diagnostik bei chronischem Tinnitus mit Hilfe des Tinnitus-Fragebogens (TF). Diagnostica 1994b; 2: 155-167.

Goebel G, Hiller W, Lenarz T, Hoke M. Ergebnisse einer Multicenterstudie mit dem Tinnitus-Fragebogen (TF). Eur Arch Otorhinolaryngol 1994; Suppl 93/II: 220-221.

Goebel G. Fortschritte bei der verhaltensmedizinischen Diagnostik und Behandlung quälender Ohrgeräusche. Otorhinolaryngol Nova 1995; 5: 178-189.

Goebel G, Hiller W, Rief W, Fichter M. Effekte und Prädiktoren verhaltensmedizinischer Behandlung des chronischen Tinnitus. 66. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, 27.-31.5. 95 Karlsruhe.

Goebel G. Der komplexe chronische Tinnitus: Neue Verhaltensmedizinische Aspekte zu Diagnostik und Therapie. Roseneck Wissenschaftsbericht 1996a; Heft 3: 43-44.

Goebel G. Tinnitus: Körperliche Ursachen und seelische Pein. In: Mauthe JH, ed. Mit Leib und Seele. Entwicklungen in Psychosomatik und Psychotherapie. Tagungsband der 13. Psychiatrietage Königslutter 1995. Königslutter: Verlag Verein zur Hilfe seel. Behinderter, 1996b: 89-139.

Goebel G. Erfassungsmethoden der Tinnitusbelastung mit dem evaluierten "Tinnitus-Fragebogen" (TF). Österreichische Gesellschaft für HNO, Bad Gastein: "Tinnitus: Sinnvolles und Sinnloses", 8.-10.3. 1996. (1996c)

Goebel G. Was hilft bei chronischen Ohrgeräuschen? 4. Bad Meinberger Tinnitus-Symposium der Deutschen Tinnitus-Liga (Leitung PD M. Pilgramm) 29./30. November 1996. (1996d)

Goebel G, Hiller W. Effects and predictors of a psychotherapeutic inpatient treatment for chronic tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 567-574.

Goebel G, Fichter M. Psychosomatische Aspekte des chronischen komplexen Tinnitus. Abschlußdiskussion. Dt Ärztebl 1996; 48: 301-320.

Goebel G. Abschlußdiskussion "Bessere Leitlinien erforderlich?" Leserbrief zu Beitrag Prochno T. DÄ 7: 313-15 "Tinnitus aus Sicht der Zahnmedizin". Dt Ärztebl 1997a; 27: 1523-1524.

Goebel G. Tinnitus aus medizinischer Sicht. In: Kröner-Herwig B, ed. Psychologische Behandlung des chronischen Tinnitus. Weinheim: PVU, 1997b: 1-13.

Goebel G. Retraining-Therapie bei Tinnitus; Paradigmenwechsel oder alter Wein in neuen Schläuchen? Editorial in HNO 1997c; 45(9): 664-667.

Goebel G. Die Verhaltensmedizinische Behandlung des chronischen Tinnitus. Psycho 1998a; 2: 78-88. Goebel G. Retraining-Therapie bei Tinnitus; Paradigmenwechsel oder alter Wein in neuen Schläuchen? Tinnitus-Forum 1998b; 1: 4-7.

Goebel G. Psychosomatische Aspekte und Therapie des chronischen Tinnitus. Seminar Vereinigung Westdeutscher HNO-Ärzte, Köln (Leitung Prof. T. Brusis), 25. April 1998. (1998c)

Goebel G. Psychiatrische Komorbidität von Patienten mit chronischem Tinnitus (Editorial). MMW 1998d; 28: 88-89.

Goebel G. Retraining-Therapie bei Tinnitus; Paradigmenwechsel oder alter Wein in neuen Schläuchen? HNO-Informationen 1998e; 2: 15-17.

Goebel G, Hiller W. Tinnitus-Fragebogen (TF). Ein Instrument zur Erfassung von Belastung und Schweregrad bei Tinnitus (Manual). Göttingen: Hogrefe, 1998.

Goebel G, Fichter M. Depression beim chronischen Tinnitus. MMW 1998; 41: 557-562.

Goebel G. Psychosomatische Aspekte zu Hörsturz und Tinnitus. In: Deutsche Fortbildungsgesellschaft der HNO, ed. Akademie für Fortbildung HNO; Kurzreferate der 32. Fortbildungsveranstaltung Hannover 1999. Neumünster: 1999a: 101-103.

Goebel G. Therapie des chronischen Tinnitus. Evaluation und Prädiktoranalyse einer multimodalen Verhaltenstherapie. Habilitationsschrift zur Erlangung der Lehrbefähigung im Fachgebiet HNO-Heilkunde (Prof. 346 (W. Arnold). Medizinische Fakultät der Technischen Universität München, 1999b.

Goebel G, Hiller W.Quality management in the therapy of chronic tinnitus. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 357-363.

Goebel G, Hiller W, Rief W, Svitak M, Fichter M, Biesinger E. Psychiatrische Komorbidität beim chronischen Tinnitus unter besonderer Berücksichtigung der somatoformen Störung. Seminar Vereinigung Westdeutscher HNO-Ärzte, Köln (Leitung Prof. T. Brusis), 24. April 1998.

Goebel G, Rübler D, Stepputat F, Hiller W, Heuser J, Fichter MM. Controlled prospective study of Tinnitus Retraining Therapy compared to Tinnitus Coping Therapy and Broad-band noise generator therapy. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London, 1999: Tinnitus and Hyperacusis Center: 302-306.

Goebel G. Somatoforme Störung bei Tinnitus. Psychiatria Danubina 2000; 12(3-4): 215-228.

Goebel G, Rübler D, Hiller W, Heuser J, Fichter M. Evaluation of Tinnitus Retraining Therapy in comparison to cognitive therapy and broad noise generator therapy. Laryngorhinootologie 2000; (Suppl.1): 588.

Goebel G, Hiller W. Verhaltensmedizinische Tinnitus-Diagnostik. Eine praktische Anleitung zur Erfassung medizinischer und psychologischer Merkmale mittels des Strukturierten Tinnitus-Interviews (STI). Göttingen: Hogrefe, 2001.

Goebel G, Hiller W. Qualitätssicherung in der Therapie des chronischen Tinnitus. Laryngorhinootologie 2000; Suppl.1: 588.

Goebel,G. (Hrsg., 2001a) Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Fachbuch Urban & Vogel, München

Goebel,G. (2001b) Wirksamkeit psychotherapeutischer Verfahren bei Tinnitus. In: Goebel,G. (Ed.):.Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Urban & Vogel, München: 97- 124

Goebel,G. (2001c) Briefe an den Tinnitus. In: Goebel,G. (Ed.):.Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Urban & Vogel, München: 227- 238

Goebel,G. (2001d) Verhaltenstherapie des chronischen TinnitusIn: Psychosomatische Störungen. Ursachen-Erkennung-Behandlung (Hrsg. G.Nissen); Symposiumsband der Würzburger therapeutischen Gespräche 2001 Kohlhammer Verlag

Goebel,G. (2001e) Tinnitus: Medizinisch- psychosomatisches Glossar. In: Goebel,G. (Ed.):.Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Urban & Vogel, München: 239-332

Goebel G.(2001f) Psychosomatische Erkrankungen im HNO- Bereich In: Brinkmann-Göbel (Hrsg.) Handbuch für Gesundheitsberater Hans Huber-Verlag, Bern: 162-179

Goebel,G. & Hiller,W. (2001a) Verhaltensmedizinische Tinnitus-Diagnostik - Eine praktische Anleitung zur Erfassung medizinischer und psychologischer Merkmale mittels des Strukturierten Tinnitus-Interview (STI) Hogrefe Verlag, Göttingen

Goebel, G. & Hiller,W. (2001b) Qualitätsmanagement in der Therapie des chronischen Tinnitus Otorhinologol Nova 10: 260- 268

Goebel,G. & von Wedel,H (2001) Tinnitus Retraining-Therapie. In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Urban & Vogel, München:83-96

Goebel, G. Rübler, D., Stepputat, F., Hiller, W., Heuser,J., Fichter, M.M. (1999) Controlled prospective Study of Tinnitus Retraining Therapy Compared to Tinnitus Coping Therapy and Broad-Band Noise Generator Therapy In: Hazell,J. (Ed.): Proceedings of the sixth International Tinnitus Seminar, Cambridge. Tinnitus and Hyperacusis Center, London: 302- 306

Goebel,G.,Hiller,W., Rief,W., Fichter,M. (2001) Integratives verhaltensmedizinisches stationäres Behandlungskonzept beim Tinnitus. In: Goebel,G. (Ed.):.Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Urban & Vogel, München: 139-176

Goebel,G., Decot,E., Marek,A. (2001a) Entscheidungshilfen bei Diagnostik und Wahl psychologischer Behandlungsmethoden HNO 49: 1036- 1047

Gold SL, Gray WC, Jastreboff PJ. Audiological evaluation and follow-up. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 485-487.

Gold SL, Frederisck EA, Formby C. Shifts in dynamic range for hyperacusis patients receiving tinnitus retraining therapy (TRT). In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 297-301.

Goldstein B, Shulman A. Tinnitus masking. A longitudinal study of efficacy. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 375-380.

Goldstein B. Stress Questionnaire. Presented at the 21st NES Congress Bad Kissingen 17.-20.3. 1994. Goldstein B, Shulmann A. Tinnitus Stress Test. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 142-147.

Gordon AG. Hyperacusis after spinal anesthesia. Anesth Analg 1991; 73(4): 506-507.

Goodey RJ. Drugs in the treatment of tinnitus. In: Evered D, Lawrenson G, eds. Tinnitus. Ciba Foundation symposium 85. London: Pitman Medical Books, 1981: 263-278.

Goodey RJ. Drug therapy in tinnitus. In: Hazell JWP, ed. Tinnitus. Edinburgh, London: Livingstone, 1987: 176-194.

Goodwin PE, Johnson RM. The loudness of tinnitus. Acta Otolaryngol 1980; 90: 353-356.

Goodwin FK, Jamison KR. Manic-depressive illness. New York: Oxford University Press, 1990.

Graber G. Neurologische und psychosomatische Aspekte der Myoarthropathien des Kauorganes. Zahnärztl Welt/Reform 1971; 21: 80.

Graber G. Myoarthropathien des Kauorganes. Med. Habilitationsschrift. Basel, 1972.

Graber G. Psychomotorik und frontolateraler Bruxismus. Myofunktionelle Aspekte der Therapie. Dtsch Zahnärztl Z 1980; 35: 592.

Graber G, Vogt HP, Müller W, Bahous J. Wei chteilrheumatismus und Myoarthropathien des Kiefer- und Gesichtsbereiches. Schweiz Mschr Zahnheilk 1980; 90 (7).

Graber G. Psychosomatische Faktoren bei Kiefergelenkerkrankungen. Schweiz Mschr Zahnheilk 1983; 93: 880.

Graber G. The influence of psychoemotional aspects on the cybernetics of occlusion. J Gnathol 1984; 3.

Graber G. Die dysfunktionsbedingten Erkrankungen im stomatognathen System (Myoarthropathie). Ätiopathogenese, Diagnostik und Therapie: Monographie. Basel: Eigenverlag Univ. Klinik, 1987.

Graessner S. Behandlungszentrum für Folteropfer, Berlin. Persönliche Mitteilung, 1993.

Graham JM, Butler J. Tinnitus in children. Tinnitus Proceedings of the Second International Tinnitus Seminar 1983. J Laryng Otol 1984; Suppl 9: 236-241.

Gray WC, Jastreboff PJ, Gold SL. Medical evaluation, diagnosis and counseling of patients with tinnitus and hyperacusis. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 494-497.

Green D, Blum DJ, Harner SG. Longitudinal follow-up of patients with Menière's disease. Otolaryngol Head Neck Surg 1991; 104: 783-788.

Greimel KV. Psychologische Maßnahmen zur Bewältigung des chronischen Tinnitus. Psychomed 1995; 7: 70-74. Greimel KV. Aspekte interdisziplinärer Zusammenarbeit (Medizin, Psychologie) bei der Behandlung von Tinnitus. Psychomed 1996; 8: 14-16.

Greuel H. Suggestivbehandlung bei Hörsturz. HNO 1983; 31: 136.

Greuel H. Viel um die Ohren. Hörsturz, Schwindel, Ohrensausen. Düsseldorf: VDG-Verlag, 1988.

Greuel H. Ambulante Behandlung von Hörbehinderungen nach Hörsturz, M. Menière und/oder artverwandtem Tinnitus. In: Viefhues, ed. Rehabilitation von Hörgeschädigten mit psychischen Störungen oder Erkrankungen. Herne: edition bosofo, 1989: 119-127.

Greuel H. Die Biomentale Therapie der Streßerkrankungen. Ergebnis eines Forschungsprojektes am Beispiel der Therapie von Hörsturz, M. Menière und Tinnitus. Düsseldorf: VDG-Verlag, 1992.

Grawe K, Donati R, Bernauer F. Psychotherapie im Wandel. Von der Konfession zur Profession. Göttingen: Hogrefe, 1994.

Groen JJ. Psychosomatic Aspects of Menière's Disease. Acta Otolaryngol 1983; 95: 407-416.

Gronholz L. Nutzen einer modifizierten Musiktherapie bei chronischem Tinnitus. Untersuchung bei 100 Patienten mittels einer randomisierten Verlaufsbeobachtung. Dissertation HNO Univ. Düsseldorf (U. Ganzer), 1997.

Grossan M. Treatment of subjective tinnitus with biofeedback. Ear Nose Throat J 1989; 55: 22-30.

Grossan M. Biofeedback. In: Morgan DH, House LR, Hall WP, Vamvas SV, eds. Das Kiefergelenk und seine Erkrankungen. Eine interdisziplinäre Betrachtung. Berlin: Quintessenz, 1985: 435-446.

Grötsch H. Die Behandlung des funktionsgestörten stomatognathen Systems mit Aufbißbehelfen und Okklusionsschienen. Grundlagen, Entwicklung und Perspektiven. Dissertation. Erlangen, 1983.

Gu LD, Pringle I, Axelsson A. Clinical experiences of acupuncture for tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 531-533.

Guck TP, Skultety FM, Meilman PW, Dowd ET. Multidisciplinary pain center follow-up study: evaluation with a notreatment control group. Pain 1985; 21: 295.

Guild J. Hypnosis for tinnitus. Can Med J 1968; 78: 426-427.

Guth PS, Risey I, Amedee R, Norris CH. A pharmacological approach to the treatment of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 115-118. 348

Gutmann G. Die funktionelle Pathologie und Klinik der Wirbelsäule, Bd. 1: Die Halswirbelsäule. Die funktionsanalytische Röntgendiagnostik der Halswirbelsäule und der Kopfgelenke. Stuttgart, New York: Fischer, 1981.

Guyot B. Therapie des komplexen chronischen Tinnitus aus der Sicht des Akustikers. In: Goebel G, ed. Interdisziplinäre Diagnostik und Therapie des komplexen chronischen Tinnitus; II. Priener Tinnitus-Symposium. Düsseldorf: Verlag für Wissenschaft und Fortbildung, 1992: 20-21.

H (back to top)

Haensler U. Das Einschleifen. Dental Revue 1983; 5.

Haerkötter C, Hiller W. Combining elements of tinnitus retraining therapy (TRT) and cognitve-behavioral therapy: Does it work? In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar 1999, Cambridge. London: Tinnitus and Hyperacusis Centre, 1999: 399-402.

Hagnebo C, Melin L, Larsen HC, Lindberg P, Lyttkens L, Scott B. The influence of vertigo, hearing impairment and tinnitus on the daily life of Menierè patients. Scand Audiol 1997; 26: 69-76.

Hahlweg K. Zur Förderung und Verbreitung psychologischer Verfahren. Ein APA-Bericht. Z Klin Psychol 1995; 24: 275-284.

Haid CT, Christ P, Wolf R, Wiegand E. Clinical suspicion of an acousticus neuroma. A neurootological review of 302 operated cases. In: Tos M, Thomson J, eds. Acoustic neurinoma. Proceedings of the First International Conference on Acoustic neurinoma. Amsterdam: Kugler, 1992: 39-44.

Halama P. Neurophysiologische Untersuchungen vor und in Hypnose am menschlichen Cortex mittels SPECT-Untersuchung - Pilotstudie. Exp klin Hypn 1992; 1990; 1: 65-73.

Halama P. Erfahrungen mit der Hypnose-Therapie bei ambulanten Patienten, die unter Tinnitus leiden. Vergleichende Pilotstudie. Exp klin Hypn 1992; 1: 49-69.

Halford JBS, Anderson SD. Anxiety and depression in tinnitus sufferers. J Psychosom Res 1991a; 35: 383-390.

Halford JBS, Anderson SD. Tinnitus severity measured by a subjective scale, audiometry and clinical judgement. J Laryngol Otol 1991b; 105: 89-93.

Halford JBS, Anderson SD. Standardized measurement of tinnitus severity. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992: 461-464.

Hallam RS, Pransansuk S, Hinchcliffe R. Neuroticism and the number of complaints of ENT outpatients in London and Bangkok. Personality Indiv Dif 1983; 4: 689-691.

Hallam RS. Psychological approaches to the evaluation and management of tinnitus distress. In: Hazell J, ed. Tinnitus. Edinburgh: Churchill Livingstone, 1984: 156-175.

Hallam RS, Rachman S, Hinchcliffe R. Psychological aspects of tinnitus. In: Rachman S, ed. Contributions to medical psychology, Vol 3. Oxford: Pergamon, 1984: 31-54.

Hallam RS, Stephens SDG. Vestibular disorder and emotional distress. J Psychosom Res 1985; 29: 407-413.

Hallam RS, Jakes SC, Chambers C, Hinchcliffe R. A comparison of different methods for assessing the "intensity" of tinnitus. Acta Otolaryngol (Stockh.) 1985; 99: 501-508.

Hallam RS, Jakes SC. An evaluation of relaxation training in chronic tinnitus sufferers. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1987: 363-365.

Hallam RS, Jakes SC, Hinchcliffe R. Cognitive variables in tinnitus annoyance. Br J Clin Psychol 1988; 27: 213-222.

Hallam R. Living with tinnitus. Dealing with the ringing in your ears. London: Thorsons, 1989.

Hallam RS. Erfahrungen mit kognitiver Gruppentherapie bei Patienten mit komplexem chronischem Tinnitus. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 153-178.

Hallam RS. Leben mit Tinnitus. München: Quintessenz, 1996a. Hallam RS. Manual of the Tinnitus Questionnaire (TQ). London: The Psychological Corporation, 1996b.

Hallam RS. Correlates of sleep disturbance in chronic distressing tinnitus. Scand Audiol 1996c; 25: 263-266.

Hallam RS. Experience of group cognitive therapy with tinnitus suffers. In: Goebel G, ed. Psychosomatic Aspects of Complex Chronic Tinnitus. London: Quintessence, 1998.

Hallam,R.S. (2001) Erfahrungen mit kognitiver Gruppentherapie bei Patienten mit komplexem chronischen Tinnitus. In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München189-200

Hallberg L, Erlandsson S, Carlsson, SG. Coping strategies used by middleaged males with noise-induced hearing loss, with and without tinnitus. Psychology and Health 1991; 7: 273-288.

Hallberg L, Erlandsson S. Tinnitus characteristics in tinnitus complainers and noncomplainers. Br J Audiol 1993; 27: 19-27.

Hallberg L, Barrenäs LRM. Living with a male with noise-induced hearing loss: experiences from the perspective of spouses. Br J Audiol 1993; 27: 255-261.

Hallberg L. Structure of perceived tinnitus in men with noise-induced hearing loss. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 575-578.

Hallberg L, Carlsson SG. Hearing impairment, coping and perceived hearing handicap in middle-ageed subjects with acquired hearing loss. Br J Audiol 1998; 25: 323-330.

Hallpike CS, Cairns H. Observations on the pathology of Menière's Syndrom. J Larnygol Otol 1938; 53: 625-655.

Hamann KF, Schwab W. Schwindel. 2nd ed. Stuttgart: Trias, 1995.

Hamilton, M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6: 278-299.

Hansen PE, Hansen JH, Bentzen O. Acupuncture treatment of chronic unilateral tinnitus: A double blind crossover trial. Clin Otolaryngol 1982; 7: 325-329.

Haralambous G, Wilson PH, Platt-Hepworth S, et al. EMG biofeedback in the treatment of tinnitus: An experimental evaluation. Behav Res Ther 25: 49-55.

Harless EL, McConell F. Effects of hearing aid use on selfconcept in older persons. J Speech Hear Disord 1982; 47: 305-309.

Harrop-Griffiths J, Katon W, Dobic R, Sakai C, Russo J. Chronic tinnitus: association with psychiatric diagnosis. J Psychosom Res 1987; 31: 613-621.

Hartland J. The value of "ego strengthening" procedures prior to direct symptom-removal under hypnosis. Am J Clin Hypn 1965; 8: 89-93.

Hartland J. Further observations on the use of "ego strengthening" technique. Am J Clin Hypn 1971; 14: 1-8.

Haskisson EC. Visual analogue scales. In: Melzack R, ed. Pain measurement and assessment. New York: Raven Press, 1983.

Hauzinger M, Bailer M, Worall H, Keller F. Das Beck-Depressionsinventar-BDI. Bern: Huber, 1991.

Hauzinger M, Bailer M. Allgemeine Depressionsskala (ADS). Weinheim: Beltz Test Gesellschaft, 1995.

Hawthorne M, O'Connor S. The psychological side of tinnitus. Br Med J 1987; 294: 1441-1442.

Hawthorne M, Britten S, O'Connor S, Webber P. The management of a population of tinnitus sufferers in a specialized clinic. J Laryngol Otol 1987; 101: 784-790.

Hazelby J. Education and tinnitus management counselling - a case study. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 629-636.

Hazell JWP. Tinnitus. In: Ballantyne J, Groves J, eds. Scott-Brown's disease of the ear, nose and throat. London: Butterworths, 1979: 81-91.

Hazell JW. Measurement of tinnitus in humans. In: Evered D, Lawrenson G, eds. Tinnitus. Ciba Foundation Symposium 85. London: Pitman Medical Books, 1981. 350

Hazell JW. Management of tinnitus: discussion paper. J R Soc Med 1985; 78 (1): 56-60.

Hazell JWP, Wood SM, Cooper HR, et al. A clinical study of tinnitus maskers. Br J Audiol 1985; 19: 65-146.

Hazell JWP, ed. Tinnitus. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 1987a: 144-155.

Hazell JWP. Surgical management of tinnitus patient. In: Hazell JWP, ed. Tinnitus. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 1987b: 144-155.

Hazell JWP. Tinnitus masking therapy. In: Hazell JWP, ed. Tinnitus. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 1987c: 96-117.

Hazell JWP, Sheldrake JB, Meerton LJ. Tinnitus masking - is it better than counselling alone? In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar Münster. Karlsruhe: Harsch, 1987: 239-250.

Hazell JWP. Tinnitus II: Surgical management of conditions associated with tinnitus and somatosounds. J Otolaryngol 1990; 19: 6-10.

Hazell JWP, Sheldrake JB. Hyperacusis and Tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler Publications, 1992: 245-248.

Hazell JWP, Jastreboff P, Meerton L, Conway M. Electrical tinnitus suppression: frequency dependence of effects. Audiology 1993; 32: 68-77.

Hazell JWP. Models of tinnitus: Generation, perception, clinical implications. In: Vernon JA, Møller, AR. Models of tinnitus. Generation, perception, clinical implications. Boston, London, Toronto: Allyn and Bacon, 1995: 57-72.

Hazell JWP. Tinnitus as a manifestation of a survival style reflex. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996a: 519-582.

Hazell JWP. Support for a neurophysiological model of the tinnitus. In: Reich G. Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996b: 51-57.

Hazell JWP. Hyperakusis und Lautheitsunbehagen. Tinnitus-Forum 1996c; 4: 17-21.

Hazell JWP. Persönliche Mitteilungen zur Effektivität der Retraining-Therapie, 1996d.

Hazell JWP. TRT homepage. http://www.ucl.ac.uk/ ~rmjg101/tinnitus1.html Hecht H, Faltermaier A, Wittchen HU. Social Interview Schedule/SIS). Halbstrukturiertes Interview zur Erfassung der aktuellen sozialpsychologischen Situation. Regensburg: Roderer, 1987.

Heers H, Reuter E. Gesichtsschmerz - Dysfunktion der Kopfgelenke. Dtsch Zahnärztl Z 1989; 12: 964-965.

Heider T, Bessmann P. Tinnitus-Patienten: Ein Erfahrungsbericht mit dem ambulanten Behandlungskonzept "Tinnitus Retraining". Verhaltenstherapie 1999; Suppl 1: 25.

Heimann H. Knochenerkrankungen; Otosklerose In: Zenner HP, ed. Praktische Therapie von Hals-Nasen-Ohren- Krankheiten: Stuttgart: Schattauer, 1993: 79-82.

Hellbrück J, Moser M. Hörgeräte-Audiometrie: Ein computergesteuertes Verfahren zur Hörgeräteanpassung. Psychologische Beiträge 1985; 27: 494-508.

Hellbrück J. Hören: Physiologie, Psychologie und Pathologie. Göttingen: Hogrefe, 1993.

Heller MF, Bergman M. Tinnitus aurium in normally hearing persons. Ann Otol Rhinol Laryng 1953; 62: 73-83.

Heller O. Hörfeldaudiometrie mit dem Verfahren der Kategorienunterteilung (KU). Psychologische Beiträge 1985; 27: 478-493.

Henry JL. Psychological management of tinnitus: An evaluation of cognitive interventions. Unpublished doctoral dissertation, University of Sydney, 1992.

Henry JL, Wilson PH. Psychological management of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992: 477-480.

Henry JL,Wilson PH. Coping with tinnitus: Two studies of psychological and audiological characteristics of patients with high and low tinnitus distress. Int Tinnitus J 1995; 1: 85-92.

Henry JL, Meikle M. Loudness recruitment only partially explains the small size of tinnitus loudness- matches. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 148-149.

Henry JL, Wilson PH. The psychological management of tinnitus: comparison of a combined cognitive educational program, education alone and a waitinglist control. Int Tinnitus J 1996; 2: 9-20.

Hesse G, Schaaf M, Almeling M. Ergebnisse einer stationären Therapie bei Patienten mit chronisch komplexem Tinnitus. Vortrag 80. Tagung Vereinigung Südwestdeutscher HNO-Ärzte, Freiburg 20.-21.9. 1996.

Hesse G, Eschler W. Lernen, den Tinnitus zu überhören. Wahrnehmungs- und Habituationstraining. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München: Profil, 1997: 39-53.

Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München: Profil, 1997.

Hesse G, Schaaf H, Kolbe U, Brehmer D, Andres R. Prescription of hearing aids for Menière patients. In: Sterkers O, Ferrary E, Daumann R, Sauvage JP, Tran Ba Huy R, eds. Menière's disease 1999 - update. Proceedings of the Fourth International Symposium of Menière's disease, Paris, France, April 11-14, 1999. The Hague: Kugler, 2000. Hesse G. Retraining und Tinnitustherapie. Stuttgart: Thieme, 1999.

Heuser J, Geissner E, Goebel G, Fichter M. The Winner and the Loser: Welche Patienten mit chronischen Schmerzen profitieren von stationärer verhaltensmedizinischer Behandlung? Schmerzkongreß, Heidelberg, Deutsche Gesellschaft zum Studium des Schmerzes (DGSS) 5/1995.

Heuser J, Geissner E, Hiller W, Goebel G, Fichter M. Interdisziplinäre Schmerztherapie bei chronischen Schmerzen: Effektivität eines stationären verhaltensmedizinischen Behandlungsprogrammes (Abstract). Schmerz 1997; 11: 56.

Heuser J. Evaluation eines stationären verhaltensmedizinischen Programmes zur Behandlung von Patienten mit chronischen Schmerzen. Dissertation Fachbereich Psychologie der Humboldt Univ. Berlin (Prof. Flor). Berlin, 1997.

Hilgard ER. Toward a neodissociation theory: multiple cognitive controls in human functioning. Perspect Biol Med 1974; 17: 301-316.

Hilgard ER. Divided consciousness in hypnosis: the implications of hidden observer. In: Fromm ER, ed. Hypnosis: developments in research and new perspectives. New York: Aldine, 1979.

Hilgard ER. Eine Neo-Dissoziationstheorie des geteilten Bewußtseins. Hypnose und Kognition 1989; 6: 3-22.

Hiller W, Mombour W, Rummler R, Mittelhammer J. Divergence and convergence of diagnoses for depression between ICD-9 and DSM-III-R. Eur Arch Psychiatry Neurol Sci 1988; 238: 39-46.

Hiller W, Wittchen HU, Zerssen D von. Faktorielle Validität: Untersuchungen zur Invarianz psychopathologischer Syndrome der IMPS (Inpatient Multidimensional Psychiatric Scale). Diagnostica 1989; 35: 236-247.

Hiller W, Bose M von, Dichtl G, Agerer D. Reliability of checklist-guided diagnoses for DSM-III-R affective and anxiety disorders. J Affect Disord 1990a; 20: 235-247.

Hiller W, Zaudig M, Mombour W. Development of diagnostic checklists for use in routine clinical care. Arch Gen Psychiatry 1990b; 7: 782-784.

Hiller,W., Zaudig, M., Mombour, W. (1995) ICDL- Internationale Diagnosen Checklisten für ICD-10 und DSM-IV.

Huber, Bern Hiller W, Goebel G. (1992) Psychiatric disorders and their degree of severity in patients with severe tinnitus and pain syndromes. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler: 441-444.

Hiller W, Goebel G, Rief W. (1994) Reliability of selfrated tinnitus distress and association with psychological symptom patterns. Br J Clinical Psychol; 33: 231-239.

Hiller W, Zaudig M, Mombour W. Internationale Diagnosen Checklisten (IDCL) für DSM-IV (IDCL für DSM-IV). Göttingen: Hogrefe, 1997.

Hiller W, Goebel G. The reliability and validity of selfrated psychological complaints in chronic tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 583-584.

Hiller W, Rief W. Was sind somatoforme Störungen? Diagnosen, Modelle und Instrumente. Psychotherapie 1997; 2: 61-70.

Hiller W, Elfant S, Margraf J, Kroymann R, Leibrand R, Fichter M. Dysfunktionale Kognitionen bei Patienten mit Somatisierungssyndrom. Z Klin Psychol 1997a; 26: 226-234.

Hiller W, Janca A, Burke K. The association between tinnitus and somatoform disorders. J Psychosom Res 1997b; 43: 613-624.

Hiller W, Zaudig M, Mombour W. Internationale Diagnosen Checklisten (IDCL) für DSM-IV (IDCL für DSM-IV). Göttingen: Hogrefe, 1997c.

Hiller W, Goebel G, Janca A, Svitak M. Association between tinnitus and the diagnostic concept of somatoform disorders. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 373-377.

Hiller W, Goebel G, Schindelmann U. Developing a structured interview to assess audiological, aetiological and psychological variables of tinnitus. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 277-285.

Hiller W, Goebel G. Assessing audiological, pathological and psychological variables in chronic tinnitus: a study of reliability and search for prognostic factors. Int J Behav Med 2000; 6: 312-330.

Hiller,W. & Goebel,G. (2001b) Komorbidität psychischer Störungen bei Tinnitus. In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München; 47-68

Hiller,W. & Goebel,G. (2001c) Hals-Nasen-Ohren-Erkrankungen (HNO) In: Herta Flor, Hahlweg,K. & Birbaumer,N. (Hrsg.): Enzyklopädie der Psychologie, Themenbereich B Praxisgebiete, Serie II, Klinische Psychologie; Band 4: Anwendungen der Verhaltensmedizin Hogrefe, Verlag für Psychologie; Göttingen, Bern, Toronto, Seattle: 147- 200

HillerW, Goebel G, Schindelmann U. Studie zur systematischen Fremdbeurteilung von Patienten mit chronischem Tinnitus (Strukturiertes Tinnitus-Interview STI). Diagnostica 2000: 46: 93-102.

Hiller H, Haerkötter C, Goebel G. Tinnitus-Retraining-Therapie (TRT): Ein sinkender Stern? Bericht 6. Internationales Tinnitus Seminar, Cambridge 5.-9. September 1999. Tinnitus-Forum 2000; I: 63-68.

Hiller W, Goebel G. Hals-Nasen-Ohren-Erkrankungen (HNO). In: Flor H, Hahlweg K, Birbaumer N, eds. Anwendungen der Verhaltensmedizin. Enzyklopädie der Psychologie: Klinische Psychologie, Vol 4. Göttingen: Hogrefe, 2001, in press. Hillert A, Cuntz U, Heldwein C, Froben B, Fichter M. Die berufliche Belastungserprobung im Rahmen klinisch-stationärer Verhaltenstherapie: Praktische Durchführung, soziodemographische und psychologische Charakteristika der Patienten als Verlaufsprädiktoren. Praxis klinische Verhaltensmedizin und Rehabilitation 1998; 42: 28-34.

Hinchcliffe R. Prevalence of the commoner ear, nose and throat conditions in the adults rural population of great britain; a study by direct examination of two random samples. Br J prev Soc Med 1961; 15: 128-139.

Hinchcliffe R. Personality profile in Menière's disease. J Laryngol Otol 1967a; 81: 477-481.

Hinchcliffe R. Personal and family medical history in Menière's disease. J Laryngol Otol 1967b; 81: 661-668.

Hinchcliffe R, Chambers C. Loudness of tinnitus: an approach to measurement. Adv Otorhinolaryngol 1983; 29: 163-173.

Hohmann D, Kügelgen B, Liebig K, Schirmer M, eds. Neuroorthopädie 1, Halswirbelsäulenerkrankungen mit Beteiligung des Nervensystems. Berlin, Heidelberg, New York: Springer, 1983.

Hoke M, Feldmann H, Pantev C, Lütkenhöner B, Lehnertz K. Objective evidence of tinnitus in auditory evoked magnetic fields. Hear Res 1989; 37: 281-286.

Hollweg W. Streik im Innenohr - Hörsturz, Morbus Menière und Tinnitus aus psychosomatischer Sicht. München: Unimed, 1989.

Hoffmann B. Handbuch des autogenen Trainings. München: Deutscher Taschenbuch Verlag, 1988.

Hoffmeister K. Verhaltensmedizinische Untersuchungen zum Hörsturz. Dissertation Univ. Tübingen, Frankfurt: Peter Lang, 1988.

Horvath T. Arousal and anxiety. In: Burrows GD, Davies B, eds. Handbook of studies in anxiety. Amsterdam: Elsevier, 1980.

House JW, Miller L, House PR. Severe tinnitus: treatment with biofeedback training (result in 41 cases). Transactions of the American Academy of Ophtalmology and Otolaryngology 1977; 84, 697-703.

House PR. Personality of the tinnitus patient. In: Evered D, Lawrenson G, eds. Tinnitus. Ciba Foundation Symposium 85. London: Pitman Medical Books, 1981: 193-203.

Huang TS, ed. Menière's disease: recent advances in basic and clinical aspects. Acta Otolaryngol Suppl 1991; 485.

Hülse M. Die Gleichgewichtsstörung bei der funktionellen Kopfgelenksstörung. Man Med 1981; 19: 92.

Hülse M, Hermann C. Katamnestische Untersuchungen zur Prognose des behandelten Hörsturzes. Laryngorhinootologie 1983; 62: 315-316.

Hupfauf L. Symptomatik und Genese chronischer Kiefergelenkserkrankungen. Dtsch Zahnärztl Z 1963; 5.

I (back to top)

Ince LP, Greene RY, Alba A, Zaretzky HH. Learned selfcontrol of tinnitus through a matching-to-sample feedback. J Behav Med 1984; 7: 355-365.

Ince LP, Greene RY, Alba A, Zaretzky HH. A matching-to- sample feedback technique for training self-control of tinnitus. Health Psychol 1987; 6: 173-182.

Ireland CE, Wilson PH, Tonkin JP, Platt-Hepworth S. An evaluation of relaxation training in the treatment of tinnitus. Behav Res Ther 1985; 23: 423-430.

Itard JMG. Die Krankheiten des Ohres und des Gehörs. Weimar, 1822.

J (back to top)

Jacobs B. Vortrag Fourth International Tinnitus Seminar (Aran JM, Dauman R). In: Goebel G. ed. Medizinisch- Psychologischer Arbeitskreis in der DTL, Bordeaux edition. Wuppertal: Tinnitus-Liga, 1991.

Jacobs B, Tromp EC. Psychosocial treatment of tinnitus. Acta Otorhinolaryngol Belg 1994; 4: 363-368.

Jacobs B, Bor G v. d. Psychological treatment of chronic tinnitus; prediction of outcome. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 585-587.

Jacobs B (in preparation). Individual versus group behavior therapy in the clinical treatment of tinnitus. Manuscript, cited in: Kröner-Herwig B, ed. Psycholo-gische Behandlung des chronischen Tinnitus. Wein-heim: PVU-Verlag, 1997.

Jacobson E. Progressive relaxation. Chicago: University Press, 1938. Jacobson GP, Newman CW. The development of the Dizziness Handicap Inventory. Arch Otolaryngol Head Neck Surg 1990; 116(4): 424-427.

Jäger K, Graber G, Humar U. Die Therapie der dys-funktionellen Erkrankung des Kausystems. Dtsch Zahnärztl Z 1990; 1: 9-13.

Jahnke K. Stadiengerechte Therapie der Menière'schen Krankheit. Dt Ärztebl 1994; 4: 428-434. 354

Jahnke K. Die intravenöse Genatamicintherapie bei beidseitigem M. Menière. Laryngorhinootologie 1997; 76: 519-522.

Jahoda G. The psychology of superstition. Baltimore: Penguin, 1969.

Jakes SC, Hallam RS, Chambers C, Hinchcliffe R. A factor analytical study of tinnitus complaint behaviour. Audiology 1985; 24: 195-206.

Jakes SC, Hallam RS, Rachmann S, Hinchcliffe R. The effects of reassurance, relaxation training and distraction on chronic tinnitus sufferers. Behav Res Ther 1986a; 24: 497-507.

Jakes SC, Hallam RS, Chambers C, Hinchcliffe R. Matched and self-reported loudness of tinnitus: methods and sources of error. Audiology 1986b; 25: 92-100.

Jakes SC, Stephens SDG. Multivariate analyses of tinnitus complaint and change in tinnitus complaint: a masker study. Br J Audiol 1987; 21: 259-272.

Jakes SC. Otological symptoms and emotions. Advances in Behavioral Research and Therapy 1988; 10: 53-103.

Jakes SC, McKenna L, Hallam RS, Hinchcliffe R. Group cognitive therapy for medical patients: an application to tinnitus. Cognitive Therapy and Research 1992; 16: 67-82.

Janca A, Isaac M, Costa e Silva JA. World Health Organisation international study of somatoform disorders - background and rationale. Eur J Psychiatry 1995; 9: 100-110.

Jannetta PJ. Microvascular decompression of the cochlear nerve as treatment of tinnitus. In: Feldmann H, ed. Third International Tinnitus Seminar. Karlsruhe: Harsch, 1987: 348-352.

Janssen T, Arnold W. Otoakustische Emissionen und Tinnitus. DPOAE - Eine Meßmethode zum objektiven Nachweis des auf der Ebene der äußeren Haarzellen entstehenden Tinnitus? Otorhinolaryngol Nova 1995; 5: 127-141.

Jansson G, Warfing J, Edensvärd A, Wiberg A. The effects of acupuncture versus masker treatment in patients with tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996.

Janz D. Über den Schwindel bei Viktor von Weizsäcker. In: Lamprecht F, ed. Spezialisierung und Integration in Psychosomatik und Psychotherapie. Berlin, Heidelberg, New York: Springer, 1987: 24-30.

Jastreboff MM. Directive counseling versus cognitive therapy. Verhaltenstherapie 1999a; 9(Suppl): 33.

Jastreboff MM. Controversies between cognitive therapies and TRT counseling. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999b: 288-291.

Jastreboff MM, Jastreboff PJ. Questionnaires of the patients and treatment outcome. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 488-490.

Jastreboff PJ, Hazell JW P. A neurophysiological approach to tinnitus: clinical implications. Br J Audiol 1983; 27: 7-17.

Jastreboff PJ, Sasaki CT. Salicylate induced changes in spontaneous activity of single units in the inferior colliculus of the guinea pig. J Acoustic Soc Am 1986; 80: 1384-1391.

Jastreboff PJ. Behavioural and electrophysiological model of tinnitus. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1987: 95-99.

Jastreboff PJ, Brennan JF, Sasaki CT. Behavioural and electrophysiological animal model of tinnitus. In: Feldmann H, ed. Proceeding of the Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987: 95-99.

Jastreboff PJ, Brennan JF, Sasaki CT. Phantom auditory sensation in rats: an animal model for tinnitus. Behav Neurosci 1988; 102: 811-822.

Jastreboff PJ. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res 1990; 8: 221-254.

Jastreboff PJ. Clinical implication of the neurophysiological model of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992: 500-507.

Jastreboff PJ, Brennan JF. Psychoacoustical characteristics of tinnitus in rats. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992: 305-308.

Jastreboff PJ, Hazell JWP. A neurophysiological approach to tinnitus: clinical implications. Br J Audiol 1993; 27: 7-17.

Jastreboff PJ, Gold SL, Gray WC. Neurophysiological approach to tinnitus and hyperacusis patients. Assoc Res Otolaryngol 1994a; 17: 9.

Jastreboff PJ, Hazell JWP, Graham RL. Neurophysiological model of tinnitus: Dependance of the minimal masking level on treatment outcome. Hear Res 1994b; 80: 216-232.

Jastreboff PJ. A neuropsychological approach to tinnitus. Theory and practice. London: Whurr, 1995.

Jastreboff PJ. Processing of the tinnitus signal within the brain. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 58-67.

Jastreboff PJ. Usefulness of the psychoacoustical characterization of tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996a: 158-166.

Jastreboff PJ. Clinical implication of the neurophysiological model of tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996b: 500-507.

Jastreboff PJ. Processing of the tinnitus signal within the brain. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association,1996c: 58-67.

Jastreboff PJ, Brennan J, Jastreboff M, et al. Recent findings from an animal model of tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 114-126.

Jastreboff PJ. Origins of tinnitus retraining therapy. Tinnitus Today 1998; March 11-12.

Jastreboff PJ. Optimal sound use in TRT-theory and practice. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999a: 491-497.

Jastreboff PJ. Categories of the patients in TRT and the treatment outcome. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999b: 494-398.

Jastreboff PJ, Sheldrake JB, Jastreboff MM. Audiometrical characterisation of hyperacusis patients before and during TRT. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 495-498.

Johnson RM. Effects of long term masking of tinnitus on hearing sensitivity. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987: 261-264.

Joisten H. Hypnotherapeutische Ansätze im Rahmen der kognitiven Verhaltenstherapie bei Tinnitus-Erkrankten. In: Fromberg J, ed. Rehabilitation Schwerhöriger, Ertaubter und Gehörloser. Kornwestheim: Salamanderdruck, 1991: 115-124.

Joisten HJ. Hypnotherapeutische Ansätze beim komplexen chronischen Tinnitus. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 191-204.

Joisten HJ. Altes Hören neu erlernen. Wahrnehmungsveränderung als Element der Tinnitusbehandlung in der Kombination von Verhaltensänderung und klinischer Erfahrung. Psychomed 1993; 5: 119-122.

Jones WL. Psychologische Behandlung. In: Morgan DH, House LR, Hall WP, Vamvas V, eds. Das Kiefergelenk und seine Erkrankungen. Eine interdisziplinäre Betrachtung. Berlin, Chicago, London: Quintessenz, 1985: 639-652.

Jones EM, White AJ. Mental health and acquired hearing impairment. A review. Br J Audiol 1990; 24: 3-9. Joraschky P, Arnold S. Unerwünschte Wirkungen der Psychotherapie. Nervenheilkunde 1992; 11: 146-152.

Jovanovic UJ. Methodik und Theorie der Hypnose. Stuttgart: Fischer, 1988.

Jung CG. Briefe I, 1906 bis 1945. Solothurn: Walter, 1972.

K (back to top)

Kaltenbach JA, Zhang J
Intense sound-induced plasticity in the dorsal cochlear nucleus of rats: Evidence for cholinergic receptor upregulation.
Hear Res. 2007 Apr;226(1-2):232-43. Epub 2006 Aug 17.
Department of Otolaryngology-Head and Neck Surgery, Wayne State University, School of Medicine, Detroit, MI 48201, United States. (Sample of the text)

Kamieth H. Das Schleudertrauma der Halswirbelsäule. Grundlagen, röntgenologische Differentialdiagnostik und Röntgenfunktionsdiagnostik. In: Die Wirbelsäule in Forschung und Praxis. Stuttgart: Hippokrates, 1990.

Kanfer FH. Basiskonzepte in der Verhaltenstherapie: Veränderungen während der letzten 30 Jahre. In: Hand I, Wittchen HU, eds. Verhaltenstherapie in der Medizin. Berlin, Heidelberg, New York: Springer, 1989: 1-16.

Kastner S, Basler HD. Messen Veränderungsfragebögen wirklich Veränderungen? Untersuchungen zur Erfolgsbeurteilung in der psychologischen Schmerztherapie. Schmerz 1997; 4: 254-262.

Katon WJ, Sullivan M, Russo J, Dobie RA, Sakai CS. Depressive symptoms and measures of diability: a prospective study. J Affect Disord 1993; 27: 245-254.

Kau RJ, Sendtner-Gress K, Ganzer U, Arnold W. Effectiveness of hyperbaric oxygen therapy in patients with acute and chronic cochlear disorders. ORL J Otorhinolaryngol Relat Spec 1997; 59(2): 79-83.

Kearny BG, Wilson PH, Haralambous G. Stress appraisal and personality characteristics of headache patients: comparison with tinnitus and normal control groups. Behaviour Change 1987; 4: 25-32.

Keel P, Wittig R, Dietheim U, Knüsel O, Rudolf T, Spring H. Multizentrisches Interventionsprojekt zur funktionellen Wiederherstellung von Patienten mit lumbalen Rückenschmerzen. In: Keel P, Perini C, Schütz-Petjean D, eds Chronifizierung von Rückenschmerzen: Hintergründe, Auswege. Schlußbericht des Nationalen Forschungsprogramms Nr. 26B. Basel: Eular-Verlag, 1995.

Keen E, et al. Emotion brooks. Monterey/Calif.: Cole, 1977.

Keeser W, Goebel G, Abeken H, Schneidzik H, Wildgruber C, Fichter M. Zeitreihenanalytische Auswertungen von Tagebüchern bei der stationären verhaltensmedizinischen Behandlung von chronischem Schmerz. Kongreß der Deutschen Gesellschaft für Verhaltensmedizin und Verhaltensmodifikation, München, Ludwigs- Maximilians-Universität, 1989.

Kellerhals B, Zogg R. Tinnitus. Ther Umsch 1995; 11: 718-723.

Kellerhals B, Zogg R. Tinnitus-Hilfe. Freiburg: Karger, 1996. Kemp DT. Stimulated acoustic emissions from within human auditory system. J Acoust Soc Am 1978; 64: 1386-1391.

Kempf HG, Zanetti F. Tinnitus, Ohrgeräusche. In: Zenner HP, ed. Praktische Therapie von Hals-Nasen- Ohren-Krankheiten. Stuttgart: Schattauer, 1993: 101-105.

Kemp S, George RN. Diaries of tinnitus sufferers. Br J Audiol 1992; 26: 381-386.

Kendall PC, Bemis KM. Thought and action in psychotherapy: The cognitive-behavioral approaches. In: Hersen M, Kazdin AE, Bellack AS, eds. The clinical psychology handbook. New York: Pergamon, 1986.

Kerany BG, Wilson PM, Halambous G. (1987) Stress appraisal and personalitiy characteristics of headache patients: comparisons with tinnitus and normal control groups. Behavior Change 1987; 4: 25-32.

Kielholz P, Pöldinger W, Adams C. Die larvierte Depression. Köln: Deutscher Ärzte-Verlag, 1981.

Kießling J. Tinnitus-Masker und Hörgeräte zur Verdeckung von Ohrgeräuschen. HNO 1980; 28 (11): 383-388.

Kießling J. Erfahrung mit dem Einsatz von Maskern und Hörgeräten zur Tinnitusverdeckung. Audiol Akustik 1981; 1: 14-21.

Kießling J. Hearing aids, maskers and instruments for tinnitus. Audiology in Practice 1986; III/2: 3-5.

Kießling J, Kollmeier B, Diller G. Versorgung und Rehabilitation mit Hörgeräten. Stuttgart: Thieme, 1997.

Kirsch CA, Blanchard EB. A multiple-baseline evaluation of the treatment of subjective tinnitus with relaxation training and biofeedback. Biofeedback Self Regul 1987; 4: 295-312.

Kirsch CA, Blanchard EB. A review of the efficacy of behavioural techniques in the treatment of subjective tinnitus. Ann Behav Med 1989; 11: 58-65.

Kirsch CA, Blanchard EB, Parnes SM. Psychological characteristics of individuals high and low in their ability to cope with tinnitus. J Psychosom Med 1989; 51: 209-217.

Kitajima K, Kitahara M, Kodama A. Can tinnitus be masked by band erased filtered masker? Masking tinnitus with sounds not covering the tinnitus frequency. Am J Otol 1987; 8 (3): 203-206.

Klein-Vogelbach S. Funktionelle Bewegungslehre. Berlin, Heidelberg, New York: Springer, 1976.

Klemm E, Schaarschmidt W. Epidemiologische Erhebungen zu Hörsturz, Vestibularisstörungen und M. Menière. HNO-Praxis 1989; 14: 295-299.

Klingmann C, Praetorius M, Baumann I, Plinkert PK
Barotrauma and Decompression Illness of the Inner Ear: 46 Cases During Treatment and Follow-Up.
Otol Neurotol. 2007 Apr 4; [Epub ahead of print]
Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany. (Sample of the text)

Klinke R. Physiologie des Gleichgewichtsorgans, des Hörens und des Sprechens. In: Schmidt RF, Thews G, eds. Physiologie des Menschen. Berlin, Heidelberg, New York: Springer, 1980.

Klockhoff I, Lindblom U. Menière's disease and Hydrochlorothiazide (Dichlotride) - a critical analysis of symptoms and therapeutic effects. Acta Otolaryngl (Stockh) 1967; 63: 347-365.

Klomsdorff RG. Hörsturz - und danach? Heidelberg: Asanger, 1995.

Klostermann W, Vieregge P, Kümpf D. Musik-Pseudohalluzinose bei erworbener Schwerhörigkeit. Fortschr Neurol Psychiatr 1992; 60: 262-273.

Kopp S, Plato G, Bumann A. Die Bedeutung der oberen Kopfgelenke bei der Ätiologie von Schmerzen im Kopf-, Hals-, Nackenbereich. Dtsch Zahnärztl Z 1989; 12: 966-967.

Kossak HC. Verhaltenstherapie nächtlicher Asthmaanfälle. Kognitive Umstrukturierung unter Hypnose. Hypnose und Kognition 1987; 4: 41-57. Kraft H. Autogenes Training. Stuttgart: Hippokrates, 1989.

Krampen G. Differentialpsychologie der Kontrollüberzeugungen. Göttingen: Hogrefe, 1982.

Kremer E, Atkins JH, Ignelzi RJ. Measurement of pain: Patient preference does not confound pain measurement. Pain 1981; 10: 241-248.

Kroger WS. Clinical and experimental hypnosis in medicine, dentistry and psychology. Philadelphia: Lippincott, 1979.

Kröner-Herwig B. Autogenes Training: Mehr Rätsel als Antworten? Die Sicht der empirischen Psychologie. Z Allg-Med 1988; 64: 594-596.

Kröner-Herwig B, Hebing B, van Rijn-Kalkmann U, Frenzel A, Schikowsky G, Esser G. The management of chronic tinnitus - what is helpful? Comparison of a cognitive-behavioral group treatment program with Yoga. J Psychosom Res 1995; 39: 153-165.

Kröner-Herwig B, Denecke H, Glier B, et al. Qualitätssicherung in der Therapie chronischer Schmerzen. IX. Multidimensionale Verfahren zur Erfassung schmerzrelevanter Aspekte und Empfehlungen zur Standarddiagnostik. Schmerz 1996; 10: 47-52.

Kröner-Herwig B, Esser G. Neue Wege in der Behandlung des chronischen idiopathischen Tinnitus. Ein Bericht über ein Folgeprojekt. Tinnitus-Forum 1997; 3: 10-17.

Kröner-Herwig B. Psychologische Behandlung des chronischen Tinnitus. Weinheim: PVU-Verlag, 1997. 358

Kröner-Herwig B. Tinnitusbewältigung versus Tinnitus Retraining-Therapie. Erste Ergebnisse einer experimentellen Untersuchung. Vortrag 3. Priener Tinnitus-Symposium 18.3. 2000.

Kröner-Herwig B, Biesinger E, Gerhards F, Goebel G, Greimel KV, Hiller W. Retraining therapy for chronic tinnitus. A critical analysis of its status. Scand Audiol 2000; 29(2): 67-78.

Kröner-Herwig,B. (2000) Rückenschmerz In: Fortschritte der Psychotherapie, Band 10 Herausgeber Prof. Dr.D.Schulte, Prof.Dr.K.Grawe, Prof.Dr.Kurt Hahlweg, Prof.Dr.D.Vaitl Hogrefe- Verlag, Göttingen Kropp UAK, Rad M v. Psychosomatische Aspekte des Hörsturz. Psychother Psychosom Med Psychol 1988; 38: 407-412.

Kroymann R, Zittlau H, Goebel G. Biofeedback in der Therapie des chronischen Tinnitus. In: Rief W, Birbaumer N, eds. Biofeedback-Therapie; Grundlagen, Indikation und praktisches Vorgehen. Stuttgart: Schattauer, 2000: 120-141.

Kügelgen BA, Hillemacher, eds. Problem Halswirbelsäule. Berlin, Heidelberg, New York: Springer, 1989.

Kuhn SK, Ikeda K, Morizono T, Murphy M. Pathophysiology of inner ear fluid imbalance. In: Huang TS, ed. Menière Disease. Recent advances in basic and clinical aspects. Acta Otolaryngol Suppl 1994; 485: 9-14.

Kuk FK, Tyler RS, Russell D, Jordan H. The psychometric properties of a tinnitus handicap questionnaire. Ear Hear 199; 11: 434-442.

Kydd WL. Psychosomatic aspects of temporomandibular joint dysfunction. J Am Dent Assoc 1959; 59: 31.

L (back to top)

Lackner J. The auditory characteristics of tinnitus resulting from cerebral injury. Exp Neurol 1976; 51: 54-67.

Lamm K. Rationale Grundlagen einer Innenohrtherapie. Otorhinolaryngol Nova 1995a ; 5: 153-160.

Lamm H. Der Einfluß der hyperbaren Sauerstofftherapie auf den Tinnitus und den Hörnerv bei akuten und chronischen Innenohrschädigungen. Otorhinolaryngol Nova 1995b; 5: 161-169.

Lamparter U, Hörmann K, Thullner J. Der Faktor Streß in der Pathogenese des Hörsturz. Verhandlungsberichte der Deutschen Gesellschaft für HNO-Heilkunde. Arch Otorhinolaryngol Suppl 1987; I/II.

Lamparter U. Studien zur Psychosomatik des Hörsturz. Habilitationsarbeit Medizinische Fakultät der Univ. Hamburg, 1994.

Lamparter U, Schmidt HU. Psychosomatic medicine and otorhinolaryngology. Psychother Psychosom 1994; 61: 25-40.

Lamparter U. Schwindel. In: Ahrens et al, ed. Psychosomatik in der Neurologie. Stuttgart: Schattauer, 1995: 122-151.

Landino A. Zur Psychosomatik des Morbus Menière. Materialien Psychoanalyse 1985; 11: 104-147.

Landis B, Landis E. Is biofeedback effective for chronic tinnitus? An intensive study with seven subjects. Am J Otolaryngol 1992; 13: 349-356.

Langner G, Wallhäusser-Franke E. Moderne Methoden der Hirnforschung zeigen: Das Phantomgeräusch Tinnitus ist eine Störung der Informationsverarbeitung im Gehirn. thema Forschung 1998; 1: 114-122.

Langner G, Wallhäusser-Franke E. Computer simulation of a tinnitus model based on labelling of tinnitus in the auditory cortex. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 20-25.

Laskin DM. Etiology of the pain dysfunction syndrome. J Am Dent Assoc 1969; 79: 147.

Laskawi R, Botulinum toxin treatment in the head and neck region : Current aspects, developments, and problems.
[Article in German] HNO. 2007 Mar 14; [Epub ahead of print]
Universitats-HNO-Klinik, Robert-Koch-Strasse 40, 37075, Gottingen, Deutschland, rlaskaw@gwdg.de. (Sample of the text)

Lauffs HJ, Ewers R. Schräglateral-transkranielle Kiefergelenkaufnahmen im Vergleich mit ihrem histologischen Korrelat. Dtsch Zahnärztl Z 1988; 43(7): 792-796.

Laux L, Glanzmann P, Schaffer P, Spielberger CD. STAI - Das Stait-Trait-Angstinventar. Theoretische Grundlagen und Handanweisungen. Weinheim: Beltz, 1991.

Lazarus RS, Folkman S. Stress, appraisal and coping. New York: Springer, 1984a.

Lazarus RS, Folkman S. Coping and adaptation. In: Gentry WD, ed Handbook of behavioural medicine. New York: Gouilford Press, 1984b: 282-325.

Leader L. Psychological aspects of tinnitus: The effects of attentional focus, anxiety and fatigue. Dissertation Univ. British Columbia. Dissertation Abstracts Internation 1987; 1: 267-B.

Lechtenberg R, Shulman A. The neurological implications of tinnitus. Arch Neurol 1984; 41: 718-721.

Lehnhardt E, Hesch RD. Übersichten über verschiedene Typen der Innenohrschwerhörigkeit. Kritisches zur Therapie. HNO 1980; 28: 74.

Lehnhardt E. Klinik der Innenohrschwerhörigkeiten: Tieftonschwerhörigkeit. Arch Otorhinolaryngol Suppl 1984; 1: 58-218.

Lempert J. Tympanosympathektomie: a surgical technique for the relief of tinnitus aurium. Arch Otorhinolaryngol 1946; 43: 199.

Lempert T. Schwindel - was steckt dahinter? Informationen und Ratschläge. München: Piper, 1994.

Lenarz T. Medikamentöse Tinnitustherapie. Stuttgart: Thieme, 1989.

Lenarz T. Probleme der Diagnostik und Therapie des chronischen Tinnitus aus HNO-ärztlicher Sicht. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992a: 17-40.

Lenarz T. Epidemiologie. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1992b: 71-75.

Lenarz T. Einheitliche Evaluierungskriterien für Therapiemethoden bei Tinnitus. Konsensuspapier über Kriterien zur einheitlichen Beurteilung und Kontrolle von Therapieverfahren bei Tinnitus auf der Basis eines Symposiums während des IV. Int. Tinnitus-Seminars in Bordeaux 1991. Audiologische Akustik 1992c; 6: 187-190.

Lenarz T. Chirurgische Therapie. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1992d: 112-115.

Lenarz T. Medikamentöse Therapie. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1992e: 101-111.

Lenarz T. Pathophysiologie des Tinnitus: Elektrophysiologische Korrelate und Ansätze für eine Objektivierung. Otorhinolaryngol Nova 1995; 5: 142-147.

Lenarz T, Schönermark M. Die progrediente Hörminderung - Pathophysiologie, Differentialdiagnostik, Therapie. Laryngorhinootologie 1995; 74: 1-6.

Lenarz T. Diagnostik und Therapie des Tinnitus. Aktuelle Standortbestimmung zur Qualitätskontrolle. Rundtischgespräch während des "Klinischen Wochenendes der Österreichischen Gesellschaft für HNO-Heilkunde", 10.3.1996, Bad Gastein.

Lenarz T. Leitlinien zur Diagnostik und Therapie des Tinnitus. Diskussionsgrundlage auf der Tagung der Arbeitsgemeinschaft deutschsprachiger Audiologen und Neurootologen (ADANO), Anhang 1, 22.3.1997, Freiburg.

Lenarz T. Diagnostik und Therapie des Tinnitus. Laryngorhinootologie 1998; 77: 54-60. Lermoyez M. Le vertige qui fait entendre. Presse Med 1919; 27: 1-3.

Leske MC. Prevalence estimates of communicative disorders in the US: language, hearing and vestibular disorders. Asha 1981; 23: 229-237.

Levine R, Kiang N. A conversation about tinnitus. In: Vernon JA, Møller AR. Mechanisms of tinnitus. Boston, London, Toronto: Allyn and Bacon, 1995: 149-161.

Levenson JL, Hamer RM, Rossiter LF. Relation of psychopathology in general medical inpatients to use and cost of service. Am J Psychiatry 1990; 147: 1498-1503.

Lewis JE, Stephens SDG, McKenna L. Tinnitus and suicide. Clin Otolaryngol 1994; 19, 50-54.

Ley P. Satisfaction, compliance and communication. Br J Clin Psychol 1982; 21: 241-254.

Liberman R, King W, de Risi W, McCann. Personal effectiveness. Champaign III: Research Press, 1975. 360

Lindberg B, Lyttkens L, Melin L, Scott B. Tinnitus - incidence and handicap. Scand Audiol 1984; 13: 287-291.

Lindberg P, Scott B, Melin L, Lyttkens L. Longterm effects of psychological treatment of tinnitus. Scand Audiol 1987; 16: 167-172.

Lindberg P, Scott B, Melin L, Lyttkens L. Behavioral therapy in the clinical management of tinnitus. J Audiol 1988; 22: 265-272.

Lindberg P, Scott B, Melin L, Lyttkens L. The psychological treatment of tinnitus: an experimental evaluation. Behav Res Ther 1989; 27: 593-603.

Lindberg B, Scott P. Ver haltenstherapie beim komplexen chronischen Tinnitus. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 165-178.

Lindberg P, Scott B. Psychological treatment of tinnitus. Abstracts of the XXVI International Congress of Psychology. Int J Psychol 1996; 31(3-4): 96.

Lindberg,P & Scott,B. (2001) Verhaltenstherapie: Exposition und Distraktion In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München: Linßen O, Schultz-Coulon HJ. Prognostische Kriterien beim Hörsturz. HNO 1997; 45: 22-29.

Linton SJ, Melin L, Stjernlöf K. The effects of applied relaxation and activity training on chronic pain. Behav Psychother 1985; 13: 87-100.

Linton SJ, Melin L. The accuracy of remembering chronic pain. Pain 1982; 13: 281-285.

Lockwood AH, Salvi RJ, Coad ML,et al.The functional neuroanatomy of tinnitus: Evidence for limbic system links and neural plasticity. Neurology 1998; 50: 114-120.

Luckhaupt H. Stellenwert der Umfelddiagnostik bei der Differentialdiagnose der akuten Schallempfindungsstörung. 94. Tagung der Vereinigung West-deutscher HNO-Ärzte, Münster. Zentralbl HNO, Plastische Chirurgie Kopf und Hals 1990; 1.

Lukas E. Sehnsucht nach Sinn. München: Profil, 1997.

Lupton DE. Psychological aspects of temporomandibular joint dysfunction. J Am Dent Ass 1969; 79: 131. 333-379_Literatur.qxd 13.09.2001 12:56 Uhr Seite 360o361

Lux-Wellendorf G. TRT: Vom 4. Frankfurter TRT-Kurs. Hörakustik 2000; 2: 74-75.

Lyttkens L, Lindberg B, Scott B, Melin L. Treatment of tinnitus by external electrical stimulation. Scand Audiol 1986; 21: 37-44.

M (back to top)

Maass B, Baumgärtl H, Lübbers DW. Lokale pO2-und pH2-Messungen mit Mikrokoaxialnadelelektroden an der Basalwindung der Katzencochlea nach akuter oberer zervikaler Sympathektomie. Arch Otorhinolaryngol 1978; 221: 269-284.

Mack H. Instrumentelle Voraussetzungen zur Erfassung des okklusoartikulären Systems. In: Drücke W, Klemt B, eds. Kiefergelenk und Okklusion. Berlin: Quintessenz, 1980: 67-80.

Mahoney MJ. Kognitive Verhaltenstherapie: Neue Entwicklungen und Integrationsschritte. München: Pfeiffer, 1979.

Main JC. Modified Somatic Perception Questionnaire MSPQ. J Psychosom Res 1983; 27: 503-514.

Majou R, Hawton K. Psychiatric disorder in the general hospital. Br J Psychiatry 1986; 149: 172-190.

Malatesta V, Sutker P, Adams H. Experimental assessment of tinnitus aurium. J Behav Assess 1980; 2: 309-317. Malinoff R, Kisiel D, Weinstein B. Aspects of tinnitus: The Tinnitus Stress Test. Presented at the 19th International Congress of Audiology. Jerusalem June 5-9, 1988.

Manson GS. Occlusion as applied to crown and bridge work. J Am Dent Ass 1920; 7, 399.

Margraf J, Schneider S, Ehlers A. "Diagnostisches Interview bei psychischen Störungen" (DIPS). Berlin: Springer, 1991.

Marks I. Fears, phobias and rituals. New York: Oxford Press, 1987.

Marks NJ, Emery P, Onisiphorou C. A controlled trial of acupuncture in tinnitus. J Laryngol Otol 1984; 98: 1103-1109.

Marks NJ, Karl H, Onisiphorou C. A controlled trial of hypnotherapy in tinnitus. Clin Otolaryngol 1985; 10: 43-46.

Marlowe FI. Effective treatment of tinnitus through hypnotherapy. Am J Clin Hypn 1973; 15: 162-165.

Martin C, Martin H, Carre J, Prades JM, Giroud F. Le facteur psychologique dans la maladie de Menière. Ann Otolaryngol Chir Cervicofac 1990; 107: 526-530.

Mason J, Rogerson D. Client-centered hypnotherapy for tinnitus: who is likely to benefit? Am J Clin Hypn 1995; 37: 294-299.

Matsuhira T, Yamashita K, Yadsuda M. Estimation of the loudness of tinnitus from matching tests. Br J Audiol 1992; 26: 397-395.

Matsushima J, Sakai N, Takeichi N, et al. Implanted electrical tinnitus suppressor. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 329-334.

Mazurek B, König O, Weber C, Jahnke V. Laryngorhinootologie 2000; Suppl.1: 195.

McCormick MS, Pritchard J. Do tinnitus maskers reduce tinnitus level: a two year review of tinnitus matching and masking (Poster). In: Feldmann H, ed. Third International Tinnitus Seminar. Karlsruhe: Harsch, 1987; 299-300.

McKenna L, Hallam RS, Hinchchliffe R. The prevalence of psychological disturbance in neurootology out-patients. Clin Otolaryngol 1987; 16: 452-456.

McKenna L, Denman C. Reertory grid technique in the assessment of cochlear implant patients. J Audiol Med 1993; 2: 75-84.

McGill JC, Lawlis GF, Selby D, Mooney V, McCoy CE. The relationship of Minnesota Multiphasic Personality Inventory (MMPI) profil clusters to pain patients. J Behav Med 1983; 6: 77-92.

McKinney J. Problem solving strategies in impulsive and reflective second grade. Developmental Psychology 1973; 8: 145.

McKinney CM, Hazell JWP, Graham RL. Persönliche Mitteilungen zur Retraining-Therapie, 1996.

McKinney CJ, Hazell JWP, Graham RL. Retraining therapy-outcome measures. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 524-525.

McShane DP, Hyde ML, Alberti PW. Tinnitus prevalence in industrial hearing loss compensation claimants. Clin Otolaryngol 1988; 13: 323-330.

Meikle M, Walsh E. Characteristics of tinnitus and related observations in over 1800 tinnitus clinic patients. Proceedings of the Second International Tinnitus Seminar, New York. J Laryngol Otol 1984; Suppl 9: 17-21.

Meikle M, Vernon J, Johnson RM. The perceived severity of tinnitus. Otolaryngol Head Neck Surg 1984; 6: 689-696.

Meikle M. Personal communication. In: MRC Institute of Hearing Research. Epidemiology of tinnitus. In: Hazell J, ed. Tinnitus. London: Churchill Livingstone, 1987: 46-70.

Meikle MB, Greist SE. The perceived localization of tinnitus. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar Münster. Karlsruhe: Harsch, 1987.

Meikle M, Greist SE. Asymmetry in tinnitus perceptions; factors that may account for higher prevalence of left-sided tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992.

Meikle M. Methods for evaluation of tinnitus relief procedures In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar. Amsterdam, New York: Kugler, 1992: 555-562.

Meikle M. The interaction of central and peripheral mechanisms in tinnitus. In: Vernon JA, Møller AR. Models of tinnitus. Generation, perception, clinical implications. Boston, London, Toronto: Allyn and Bacon, 1995: 181-206.

Meikle M, Henry JA, Mitchell C. Methods for matching the loudness of tinnitus using external tones. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 178-179.

Melzack R, Wall PD. Pain mechanisms: a new theory. Science 1965; 150: 971-979.

Mensen H. Autogenes Training in Prävention und Rehabilitation. Erlangen: Perimed, 1988.

Mensen H. Das Autogene Training. München: Goldmann, 1991.

Meric C, Gartner M, Collet L, Chéry-Croze S. Correlations between psychological profile of sufferers and tinnitus impact on life. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 596-606.

Melin L, Scott B, Lindberg P, Lyttkens L. Hearing aids and tinnitus - an experimental group study. Br J Audiol 1987; 21, 91-97.

Melin L, Scott B, Lindberg B, Lyttkens L. Hearing aids and tinnitus - an experimental group study. Br J Audiol 1989; 21: 91-97.

Mersey H, Watson GD. The lateralisation of pain. Pain 1979; 7: 271-280.

Meulenbroeks A, et. al. Paroxysmaler Lagerungsschwindel: über die Bedeutung des Semontschen Manövers zur Therapie. Otorhinolaryngool Nova 1996; 6: 92-95.

Meyer ED, Fehlinger R, Sauermann K, et al. Untersuchungen zur Bedeutung von Magnesiummangel und tetanischer Reaktionsbereitschaft für die Hörsturz-pathogenese. HNO-Praxis 1986; 11: 283-389.

Michel O. Schall aus dem Ohr: Hörstörungen im Licht der neuen Hörtheorie. medwelt 1993; 44: 472-476. Michel O. Der Hörsturz. Stuttgart: Thieme, 1994.

Michel O. Hörsturz: Pathophysiologie - Diagnostik - Therapie. HNO-Informationen 1997; 3, Einlage. Michel O. M. Menière und verwandte Gleichgewichtsstörungen. Stuttgart: Thieme, 1998.

Mihalyka EE, Whanger AD. Objective tinnitus aurium hypnotically treated. Am J Clin Hypn 1959; 2: 85-86.

Milz H, Goebel G. Schlägt sich Angst aufs Gehör nieder? Überlegungen zu körpertherapeutischen Möglichkeiten beim komplexen chronischen Tinnitus. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 231-244.

Mirz F, Gjedde A, Stødkilde-Jørgensen H, Pedersen CB. Neuroanatomical correlates of induced tinnitus. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 323-327.

Mitchell C. The masking of tinnitus with pure tones. Audiology 1983; 22: 73-87.

Modestin J. Schwindel als psychosomatisches Phänomen. Psychother Psychosom Med Psychol 1983; 33: 77-86.

Mohr F. Psychophysische Behandlungsmethoden. Leipzig: Hirzel, 1925: 138-146.

Møller A. Pathophysiology of tinnitus. Ann Otolaryngol 1984; 93: 39-44.

Møller AR. Similarities between tinnitus and pain. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 449-454.

Møller AR. Pathophysiology of severe tinnitus and chronic pain. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 26-31.

Mongini F. Lageanomalien von Kondyle und Okklusion. In: Solberg WK, Clark GT, eds. Kieferfunktion - Diagnostik und Therapie. Berlin: Quintessenz, 1985: 25-53.

Morgan DH. Surgical correction of temporomandibular arthritis. J Oral Surg 1975; 33: 766.

Morgenstern C. Pathophysiologie, Klinik und konservative Therapie der Menièreschen Erkrankung. In: Verhandlungsbericht der Deutschen Gesellschaft für Hals-Nasen-Ohrenheilkunde. Arch Otorhinolaryngol Berlin 1985; 1-66.

Morgenstern C. Morbus Menière. In: Naumann HH, et al, eds. Oto-Rhino-Laryngologie in Klinik und Praxis, Bd 1: Ohr. Stuttgart: Thieme, 1994: 768-775.

Moritz W. Das cervicale Sympathikussyndrom und seine praktische Bedeutung. Z Laryngol Rhinol 1953; 32: 270.

Motsch A. Funktionsorientierte Einschleiftechnik für das natürliche Gebiß. München: Hanser, 1978.

Motsch A. Das sogenannte Costen-Syndrom. In: Drücke W, Klemt B, eds. Kiefergelenk und Okklusion. Berlin: Quintessenz, 1978: 99-110.

MRC Institute of Hearing Research. Epidemiology of tinnitus. In: Hazell J, ed. Tinnitus. London: Churchill Livingstone, 1987: 46-70.

Mühlnickel W, Elbert T, Taub E, Flor H. Kortikale Reorganisation bei Tinnitus. Verhaltenstherapie 2000; Suppl 1: 50. Müller W. Tinnitus und Coping; Veränderung des Bewältigungsverhaltens bei Patienten mit komplexem chronischen Tinnitus durch eine integrative verhaltensmedizinische Therapie in Abhängigkeit vom Therapieerfolg. Diplomarbeit Psycholog. Institut Universität Kiel, 1996.

Münzel K, Sandner S. Kritische Lebensereignisse und Belastungsverarbeitung bei Patienten mit idiopathischem Hörsturz. 12. Symposium Klinisch Psychologische Forschung, Fribourg/Ch, 12.-14.5.1994.

Muggenthaler KH, Strohmayr J, Klügel C, Kastner E. Einsatz der visuellen Analogskala zur Evaluierung der Effizienz der hyperbaren Oxygenation (HBO)-Therpaie) bei Patienten mit Tinnitus und/ oder Hörsturz. Schmerz 1997; 11: 73.

Murai K, Tyler RS, Harker LA, Stouffer JL. Review of pharmacological treatment of tinnitus. Am J Otol 1992; 98: 1103-1109.

Muthny FA. Krankheitsverarbeitung bei chronisch körperlich Kranken. Prax Psychother Psychosom 1989; 34: 64-72.

Myrhaug H. Parafunktionen im Kauapparat als Ursache eines otodentalen Syndroms. Quintessenz-Journal 1969; 6/7: Ref 3876.

N (back to top)

Nadol JB, ed. Menière's disease - Pathogenesis, pathophysiology, diagnosis and treatment. Amsterdam: Kugler & Ghendi, 1989.

Nadol JB. Hearing loss. N Engl J Med 1993 Oct 7; 329 (15): 1092-102.

National Center for Health Statistics. Hearing levels of adults by race, region and area of residence, United States, 1960-1962. Vital and Health Statistics Publication 196; Series 11: No 26.

National Center for Health Statistics. Basic data on hearing levels of adults 25-74 years, United States, 1971-1975.Vital and Health Statistics Publication 1980; Series 11: No 215.

National Center for Health Statistics. National Ambulatory Medical Care Survey, 1980-1981. Vital and Health Statistics. Washington, DC: Public Health Service. US Dept. of Health and Human Services publication 1984; PHS 84-1741. Series 13, No 80.

National Center for Health Statistics. Current estimates from the National Health Interview Survey 1989. Vital and health statistics. Series 10, No. 176. (DHHS publication no. 90-1504). Washington DC: Government Printing office. US Dept. of Health and Human Services publication 1990; PHS 84-1741. Series 13, No 80.

Negri B, Schorn K. Gutachterliche Aspekte bei der Beurteilung von Tinnitus bei der Lärmschwerhörigkeit. HNO-Informationen 1990; 1: 84.

Nelting M. Stationäre Behandlung des chronisch komplexen Tinnitusleidens. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München: Profil, 1997: 12-27.

Nelting M, Hesse G, Schaaf H. Tinnitustherapie - mit Leib und Seele. München: Profil, 1998/2001.

Neuhauser W. Probleme der Diagnostik, Überweisung und Behandlungseinleitung aus zahnärztlicher Sicht. In: Ermann M, Neuhauser W, eds. Der orofaziale Schmerz. Perspektiven für eine Zusammenarbeit zwischen Zahnmedizin und Psychosomatik. 1990: 19-23.

Neuhauser W. Tinnitus als zahnärztliches Problem. Kiefergelenksaffektionen und Bruxismus. Diagnostische und therapeutische Möglichkeiten. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 245-270.

Neuhauser, W. (2001) Tinnitus als zahnärztliches Problem. In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München: 257-278

Neuhuber WL, Zenker W, Bankoul S. Central projections of cervical primary afferents in the rat. Some general anatomical principles and their functional significance. The primary afferent neuron. Plenum Publishing Corporation, 1990.

Neumer S, Margraf J. Kostenmäßige Effektivitäts- und Kosten-Nutzen-Analyse. In: Margraf J, ed. Lehrbuch der Verhaltenstherapie, Band 1. Berlin: Springer, 1996: 543-555.

Neuser J, Knoop T. Sudden idiopathic hearing loss: Psychopathology and antecedent stressful life-events. Br J Med Psychol 1986; 59: 245-251.

Newman CW, Jacobson GB, Spitzer JB. Development of the Tinnitus Handicap Inventory. Arch Otolaryngol Head Neck Surg 1996; 122: 143-148.

Newman CW, Eharton JA, Jacobson GP. Self-focused and somatic attention in patients with tinnitus. J Am Acad Audio 1997; 8: 143-149.

Newman C. Development of the tinnitus handicap inventory. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 186-192.

Niedermeyer HP, Arnold W, Lehn N. Antikörper gegen Viren in der Perilymphe von Patienten mit M. Menière. HNO Informationen 1996; 4: 141.

Nieschalk M, Winter B, Stoll W. Neue Erfahrungen mit dem "Tinnitusbewältigungstraining". Ein Vergleich von Einzel- und Gruppentherapie. 66. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde 1995. HNO-Informationen 1995; 1: 90.

Nieschalk M, Stoll W. Die direkte Lautheitsskalierung in der Diagnostik von Ohrgeräuschen. HNO 1996; 44: 577-584.

Nilges P, Kröner-Herwig B, Denecke H, et al. Qualitätssicherung in der Therapie chronischer Schmerzen. IX. Verfahren zur Erfassung von Behinderung/Beeinträchtigung. Schmerz 1995; 9: 242-245.

Nodar RH. Tinnitus aurium in school age children: a survey. J Audit Res 1972; 12: 133-135.

Nodar RH. Tinnitus reclassified: new oil in an old lamp. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996.

Novacek T. Rehabilitation von Schwerhörigen. Entwicklung, Durchführung und Evaluation eines psychologischen Trainings. Diplomarbeit an der Psychologie VI der Katholischen Universität Eichstätt (Prof. J. Hellbrück), 1996.

O (back to top)

O'Connor S, Hawthorn M, Britten S, Webber P. Identification of psychiatric morbidity in a population of tinnitus sufferes. J Laryngol Otolo 1987; 101: 791-794.

O'Connor KP, Hallam R, Beyts J, Hinchcliffe R. Dizziness: behavioral, subjective and organic aspects. J Psychosom Res 1988; 32: 291-302.

Öhmann A. The orienting response, attention and learning: an infirmationprosessing perspective. In: Kimmel EH, van Olst EH, Orlebeke JF, eds. The orienting reflex in humans. Hillsdale: Erlbaum, 1979: 443-471.

Office of Population Census and Surveys - OPC. General Household Survey: The prevalence of tinnitus. London: OPCS, 1983.

Ogata Y, Sekitani T, Moriya K, Watanabe K. Biofeedback therapy in the treatment of tinnitus. Auris Nasus Larynx 1993; 20: 95-101.

Olbrich D, Kostka EF, Schneider E. Welche Patienten in der psychosomatischen Rehabilitation sind psycho therapeutisch erreichbar? Rehabilitation 1995; 34: 16-22.

Olderog M. Metanalyse zur Wirksamkeit psychologisch fundierter Behandlungskonzepte des chronischen dekompensierten Tinnitus. Z Med Psychol 1999; 1: 5-18.

Öst LG. Applied relaxation: description of a coping technique and review of controlled studies. Behav Res ther 1987; 25: 397-409.

Oystragh P. The relief of symptoms by the use of hypnosis. Br J Clin Hypn 1974; 5: 38.

P (back to top)

Palla S. Determinanten und Röntgenanalyse der Kondylenposition. In: Solberg WK, Clark GT, eds. Kieferfunktion - Diagnostik und Therapie. Berlin: Quintessenz, 1985: 55-80.

Paparella MM. Methods of diagnosis and treatment of Menière´s disease. In: Huang TS, ed. Menière's disease: recent advances in basic and clinical aspects. Acta Otolaryngol Suppl 1991; 485: 108-119.

Parker W, Chole R. Tinnitus, vertigo and temporomandibular disorders. Am J Orthod Dentofa Orthop 1995; 107: 153-158 Partheniadis-Stumpf M, Teshmar E, Maurer J, Mann W. Akupunktur bei der Behandlung von Tinnitus. Oto-laryngol Nova 1994; 4: 66-68.

Pearson MM, Barnes LJ. Objective tinnitus aurium: report of two cases with good results after hypnosis. J Philadelphia General Hospital 1950; 1: 134-138.

Penner MJ, Brauth S, Hood L. The temporal course of the masking of tinnitus as a basis for inferring its origin. J Speech Hear Res 1981; 24: 257-261.

Perrig-Chiello P, Gussek S. Differentielle Aspekte der subjektiven Belastung durch Tinnitus aurium. Psychother Psychosom Med Psychol 1996; 46: 139-146.

Pershad SK, Verma SK. Measurements of change in psychological functioning following illness and therapeutic intervention. Ind J Clin Psychol 1989; 16: 64-67.

Peter B, Kraiker Ch, Revenstorf D. Hypnose und Verhaltenstherapie. Bern, Stuttgart, Toronto: Huber, 1991.

Peter B. Möglichkeiten und Grenzen der Hypnose in der Schmerzbehandlung. Schmerz 1998; 3: 179-186.

Pfaller K, Arvidsson J. Central distribution of trigeminal and upper cervical primary afferents in the rat studied by anterograde transport of horseradish peroxidase conjugated to wheat germ agglutinin. J Comp Neurol 1988; Feb 1; 268(1): 91-108.

Pfaltz CR, ed. Controversial aspects of Menière's disease. Stuttgart: Thieme, 1986.

Pfingsten M, Franz C, Hildebrandt J, Sauer P, Seeger D. Das Göttinger Rücken Intensiv Programm (GRIP). Ein multimodales Behandlungsprogramm für Patienten mit chronischen Rückenschmerzen, Teil 3: Psychosoziale Aspekte. Schmerz 1996; 10: 326-344.

Pfingsten M, Hildebrandt J, Sauer P, Franz C, Seeger D. Das Göttinger Rücken Intensiv Programm (GRIP). Ein multimodales Behandlungsprogramm für Patienten mit chronischen Rückenschmerzen, Teil 4: Prognostik und Fazit. Schmerz 1997a; 11: 30-41.

Pfingsten M, Kaluza G, Hildebrandt J. Rückenschmerzen. In: Basler HD, Franz C, Seemann H, Kröner-Herwig B, Rehfisch HP, ed. Psychologische Schmerztherapie, 4. Auflage. Berlin, Heidelberg, New York: Springer, 1999.

Phoon WH, Lee HS, Chia SE. Tinitus in noise-exposed workers. Occup Med 1993; 43: 35-38.

Pilgramm M, Rychlik R, Lebisch H, Siedentop H, Goebel G, Kirschhoff D. Tinnitus in der Bundesrepublik Deutschland; eine repräsentative epidemiologische Studie. HNO aktuell 1999; 7: 261-265.

Pilgramm M, Rychlik R, Lebisch H, Siedentop H, Goebel G, Kirschoff D. Tinnitus in the Federal Republic of Germany: A representative epidemiological study. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 64-67.

Pilling LF. Psychosomatic aspects of facial pain. In: Alling CC, Mahan PE, eds. Facial pain. Philadelphia: Lea & Febinger, 1977: 213-226.

Plath P. Probleme der Spätversorgung mit Hörgeräten. In: Verch K, ed. Rehabilitation Schwerhöriger, Ertaubter und Gehörloser. Internationale Tagung 1989, Bad Berleburg. Bad Berleburg: Wittgensteiner Kuranstalt und Diakonisches Werk, 1989.

Plath P. Lärmschäden des Gehörs und ihre Begutachtung. Schriftenreihe für den HNO-Arzt. Kind Hörgeräte, 1991a.

Plath P. Lärmschäden des Gehörs und ihre Begutachtung. Hannover: Schlütersche, 1991b.

Podoshin L, Ben-David Y, Fradis M, Gerstel R, Felner H. Idiopathic subjective tinnitus treated by biofeedback, acupuncture and drug therapy. Ear Nose Throat J 1991; 70: 284-289.

Praetorius C. Krankheitserleben und Bewältigungsformen bei Morbus Menière-Patienten. Michelstadt, Neuthor, 1995.

Pratt RT, McKenzie W. Anxiety states following vestibular disorders. Lancet 1958; 2: 347-349.

Preßl W. Tinnitus: die Qual im Ohr. Psychologie heute 1996; 12: 44-49.

Preyer S, Bootz F. Tinnitusmodelle zur Verwendung bei der Tinnituscounsellingtherapie des chronischen Tinnitus. HNO 1995; 43: 338-351.

Prentiss HA. A preliminary report upon the temporomandibular articulation in the human type. Dent Cosmos 1918; 60: 505.

Pringle I, Axelsson A, Holgers KM. Cumulative treatment results in Tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 526-530.

Prohaska J, Clemente C Di. Toward a comprehensive model of change. In: Miller W, Heather N. Treating addictive behaviors. New York: Plenum Press, 1985: 3-27.

Prochno T. Tinnitus aus der Sicht der Zahnmedizin. Dt Ärztebl 1997; 7: 313-315.

Prytulla I, Tönnies S, et al. Poster Deutsche Gesellschaft für Psychologie, 28. September 1998, Dresden. 333-379

Pujol R. Neuropharmacology of the cochlea and tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 103-107.

Pulec JL, Hodell SF, Anthony PF. Tinnitus: diagnosis and treatment. Ann Otol Rhinol Laryngol 1978; 87: 821-833.

Q (back to top)

R (back to top)

Rabaioli-Fischer,B. (2001) Verhaltenstherapie in der psychologischen Praxis In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München; 125-138

Rad M v., Schors R, Finke G. Psychosomatische Medizin und stationäre Psychotherapie in einem Allgemeinkrankenhaus. In: Tress W, ed. Psychosomatische Medizin und Psychotherapie in Deutschland. Göttingen: Vandenhoeck und Ruprecht, 1992.

Ramfjord SP, Ash MM. Occlusion. Philadelphia: Saunders, 1971.

Rateitschak KH, Wolf HF. Parodontologie - Farbatlanten der Zahnmedizin, Band 1. Stuttgart: Thieme, 1984.

Reich J, Russell W. Anxiety symptoms distinguishing social phobia from panic and generalized anxiety disorders. J Nerv Ment Dis 1988; 176: 510-513.

Reich G, Johnson RM. Personality characteristics of tinnitus patients. J Laryngol Otol 1984; 9: 228-232.

Reich G, Griest S. A survey of hyperacusis patients. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux.Amsterdam, New York: Kugler, 1992: 249-253.

Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996.

Renggli HH, Mühlemann HR, Rateitschak KH. Parodontologie. Stuttgart: Thieme, 1984.

Repik I, Rienhoff NK, Brehmer D, Kinkel M, Hesse G. Ergebnisse der ambulanten Tinnitus-Retraining-Therapie. Z Audiol 2000; 39 (2): 32-39.

Revenstorf D. Hypnose und Verhaltenstherapie. Hypnose und Kognition1987; 4: 10-21.

Richtberg W. Hörbehinderung als psychosoziales Leiden. In: Der Bundesminister für Arbeit und Sozialordnung, ed. Forschungsbericht 32, Gesundheitsforschung, Bonn, 1980.

Richtberg W. Psychosomatische Probleme und Aufgaben in der Hals-Nasen-Ohrenheilkunde. In: Richtberg W, Verch K, ed. Hilfen für Hörgeschädigte. St. Augustin: Academia Verlag, 1993: 135-144.

Richter I. Eine besondere Herausforderung: Psychiatrische Diagnostik und Therapie bei Gehörlosen. Psycho 1993; 19: 423-435.

Riediger D, Ehrenfeld M. Zur Pathogenese und Klinik des Styloidsyndroms. Dtsch Zahnärztl Z 1989; 12: 968-970.

Rief W, Hiller W. Somatoforme Störungen. Körperliche Symptome ohne organische Ursache. Bern: Huber, 1992.

Rief W. Ein Plädoyer für eine praxisorientierte Psychotherapieforschung. Report Psychologie 1994; 19: 16-19.

Rief W. Multiple somatoforme Symptome und Hypochondrie. Empirische Beiträge zur Diagnostik und Behandlung. Göttingen, Bern, Toronto: Huber, 1994.

Rief W, Heuser J, Fichter M. Biofeedback - ein therapeutischer Ansatz zwischen Begeisterung und Ablehnung. Verhaltenstherapie 1996; 6: 43-50.

Rief W, Hiller W. SOMS - Das Screening für Somatoforme Störungen. Bern: Huber, 1997.

Rief W, Shaw R, Fichter M. Elevated levels of psychophysiological arousal and cortisol in patients with somatization syndrome. Psychosom Med 1998; 60(2): 198-203.

Rienhoff NK.Geräuschempfindlichkeits-Fragebogen (GEMPF). In: Hesse G. Retraining und Tinnitustherapie. Stuttgart: Thieme, 1999: 95.

Robinson SK, Viirre ES, Stein MB - Antidepressant therapy in tinnitus.
Hear Res. 2007 Apr;226(1-2):221-31. Epub 2006 Sep 14.
Department of Psychiatry, University of California, San Diego School of Medicine, Veterans Administration San Diego Healthcare System, 3350 La Jolla Village Dr., Mail Code 116A, La Jolla, CA 92161, USA. (Sample of the text)

Rodde S, Margraf J, El Falaki A, Schneider S. Läßt sich quantitativ erfassen, was Therapeuten in Therapiestudien wirklich tun? Verhaltenstherapie 1996; 6: 135-141.

Roeser RJ, Price DR. Clinical experience with tinnitus maskers. Ear Hear 1980; 1(2): 63-68.

Roos UM. Endolymphhydrops, fluktuierendes Hörvermögen, rezidivierender Tieftonverlust. In: Zenner, HP, ed. Praktische Therapie von Hals-Nasen-Ohren-Krankheiten. Stuttgart: Schattauer, 1993a: 90-91.

Roos UM. Kombinierte vestibulo-cochleäre Läsionen. In: Zenner HP, ed. Praktische Therapie von Hals-Nasen- Ohren-Krankheiten. Stuttgart: Schattauer, 1993b: 115-117.

Rotter JB. Generalized expectancies for internal versus external control of reinforcement. Psychological Monographs 1966; 1: 80.

Rubinstein B. Effects of stomatognathic treatment on tinnitus - a retrospective study. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar. Karlsruhe: Harsch, 1987: 385-388.

Rubinstein B, Erlandsson S. A stomatognathic analysis of patients with disabling tinnitus and craniomandibular disorders (CMD). Br J Audiol 1991; 25: 77-83.

Rubinstein B. Zahnärztliche und psychophysiologische Therapie (Biofeedback) bei stomatognathogenem chronischen Tinnitus. In: Goebel G, ed. Interdisziplinäre Diagnostik und Therapie des komplexen chronischen Tinnitus. II. Priener Tinnitus-Symposium. Düsseldorf: Verlag für Wissenschaft und Fortbildung, 1992a: 15-16.

Rubinstein B, Österberg T, Rosenhall U. Longitudinal fluctuations in tinnitus as reported by an elderly population. J Audiol Med 1992b; 1: 149-155.

Rubinstein B, Alquist M, Bengtsson C. Hyperacusis, tinnitus, headache, temporomandibular disorders and amalgam fillings - an epidemiological study. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 657-658.

Rubinstein B, Wänman A. Epidemiological Study of tinnitus and its correlates. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 655-656.

Rübler D. Durchführung und Evaluation eines multidimensionalen Tinnitus-Bewältigungstrainings. Diplomarbeit (D. Hellhammer, F. Gerhards) Fachbereich 1 - Psychologie Univ. Trier, 1996. 368

Rudack C. Immunologie des Innenohres. Ein Überblick. HNO 1995; 43: 275-281.

Rüger U, Blomert AF, Förstere W.Coping. Theoretische Konzepte, Forschungsansätze, Meßinstrumente zur Krankheitsbewältigung. Göttingen: Vandenhoeck & Ruprecht, 1990.

Rugh JB, Solberg WK. Psychological implications in temporomandibular pain and dysfunction. In: Zarb GH, Carlsson GE, eds. Temporomandibular joint-function and dysfunction. Kopenhagen: Munksgaard, 1979: 239-268.

Russo J, Katon W, Sullivan M, Clark M, Buchwald D. Somatization and its relationship to psychiatric disorders and personality. Psychosomatics 1993; 6: 546-556.

Rüster P. Psychosomatik und Psychopathologie von Morbus Menière. Dissertation, Universität Hamburg. 1989.

S (back to top)

Sacerdote P. Techniques of hypnotic intervention with pain patients. In: Barber JB, Adrian C, eds. Psychological approaches to the management of pain. New York: Brunner/Mazel, 1982.

Salkovskis PM, Clark DM, Hackmann A. Treatment of panic attacks using cognitive therapy without exposure or breathing retraining. Behav Res Ther 1991; 29: 161-166.

Salvi R. Plasticity and reorganization in the inferior colliculus and cochlear nucleus following acute cochlear damage. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 457-466.

Sanchez L, Stephens D. A tinnitus problem questionnaire in a clinic population. Ear Hear 1997; 18: 210-217.

Sander M, Siegert R, Gundlach KKH. Erfahrungen mit der krankengymnastischen Behandlung von Patienten mit kaumuskulären Funktionsstörungen. Krankengymnastik 1990; 42: 662-667.

Sank LI, Shaffer CS. A therapist's manual for cognitive behaviour therapy for medical patients: an application to tinnitus. New York: Plenum, 1984.

Savastano M, Brescia G, Marioni G - Antioxidant therapy in idiopathic tinnitus: preliminary outcomes.
Arch Med Res. 2007 May;38(4):456-9. Epub 2007 Mar 12.
Department of Otolaryngology Head Neck Surgery, Padua University, Padua, Italy.
(Sample of the text)

Savastano M, Marioni G, Aita M - Psychological characteristics of patients with Meniere's disease compared with patients with vertigo, tinnitus, or hearing loss.
Ear Nose Throat J. 2007 Mar;86(3):148-156
ENT Section, Department of Medical-Surgical Specialities, Padova University Hospital, Padova, Italy. marina.savastano@unipd.it (Sample of the text)

Saß H, Wittchen HU, Zaudig M. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-IV. Göttingen: Hogrefe, 2000.

Schaaf H. Morbus Menière. Krieg im Innenohr. Berlin: Springer, 1995a.

Schaaf H. Tinnitus, Hörverlust und Schwindel: Die Menièresche Krankheit. psychomed 1995b; 7: 75-78.

Schaaf H. Was den Tinnitus schwinde(l)n läßt: Die Menièresche Krankheit. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München, Wien: Profil, 1997a: 86-97.

Schaaf H. Tinnitus als Chance? In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München, Wien: Profil, 1997b: 113-115.

Schaaf H. Hören - ein hochkomplexer Vorgang mit phantastischen Täuschungsmöglichkeiten … Anatomische und physiologische Grundlagen des Tinnitus-Leidens. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München: Profil, 1997c: 12-27.

Schaaf H. Wie der Dicke Zeh das Tinnituserleben verändern kann. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München: Profil, 1997d: 98-101.

Schaaf H, Eschler W. Schlaflos durch Tinnitus? Schlafstörungen bei Tinnitus-Betroffenen. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München: Profil, 1997: 54-63.

Schaaf H, Holtmann H. Wenn das Ohr die Seele stolpern läßt. KIMM aktuell. 12/1997, Waiblingen.

Schaaf H, Hesse G, Nelting M. Nicht Hörsturz - nicht Menière: Fluktuierender Tieftontinnitus und wiederholter Tieftonverlust bei Endolymph-Schwankungen. In: Hesse, G, Nelting, M, Schaaf, H. Tinnitus: Leiden und Chance. München: Profil, 1997: 75-85.

Schaaf H. M. Meniére. Ein psychosomatischer Leitfaden. 2nd ed. Heidelberg: Springer, 1998a.

Schaaf H. Brummender und tönender Hörverlust: Endolymphschwankungen mit wechselndem Tieftontinnitus und wiederholter Tieftonverlust. In: Tinnitus Klinik Arolsen, ed. Praktische Aspekte des Retrainings und der Hörtherapie. Arolser Schriften 1998b; II: 43-76.

Schaaf H. Zwischen Hoffen und Bangen. Tinnitus Bewältigungsstrategien nach der akuten und vor der chronischen Phase. In: Tinnitus Klinik Arolsen, ed. Hyperakusis. Arolser Schriften 1998c; III: 57-72.

Schaaf H. Schwindel - Schwinden - Schwindeln: eine Hinführung. In: Schaaf H, Nelting M, Hesse G. Schwindel - psychosomatisch gesehen. München, Wien: Profil, 1999a: 11-17.

Schaaf H. Hilfestellungen aus der Verhaltenstherapie bei Schwindelerkrankungen. In: Schaaf H, Nelting M, Hesse G. Schwindel - psychosomatisch gesehen. München, Wien: Profil, 1999b: 81-86.

Schaaf H. Die cochleäre Endolymphschwankung. Rezidivierende Hörverluste mit tieffrequentem Tinnitus. In: Hesse G, ed. Retraining und Tinnitustherapie. Stuttgart: Thieme, 1999c: 84-87.

Schaaf H. Unterstützende und begleitende Behandlungen: Entspannungsverfahren, Bewegungstherapien In: Hesse G, ed. Retraining und Tinnitustherapie. Stuttgart: Thieme, 1999d: 82-83.

Schaaf H. Die Hörwirklichkeit ist einzigartig und gestaltbar. In: Mecklenburg, ed. Die Welt in den Ohren. Lebensqualität mit Tinnitus. Sinnlich spürend lernen - leben - handeln. Dortmund: Verlag Modernes Lernen, 1999e: 15-36.

Schaaf H, Hesse G. Tinnitus aurium. Alarm aus dem Innenohr. München: Midena, 1999a: 128.

Schaaf H, Hesse G. TRT: Tinnitus Retraining Therapie. Psychomed 1999b; 11/3: 170-173.

Schaaf H, Holtmann H. Psychotherapie in der ambulanten Tinnitusbehandlung. Verhaltenstherapeutische Ansätze. In: Hesse G, ed. Retraining und Tinnitustherapie. Stuttgart: Thieme, 1999: 71-81.

Schaaf H, Holtmann H, Hesse G. Die Menièresche Erkrankung. Schwindel an Leib und Seele. In: Schaaf H, Nelting M, Hesse G. Schwindel - psychosomatisch gesehen. München, Wien: Profil, 1999a: 44-58.

Schaaf,H. (2001) Morbus Menière: Klinik und psychosomatische Behandlungsansätze In: Goebel,G. (Ed.):.Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus Urban & Vogel, München: 239-256 Kolbe U, Brehmer D. Der (reaktive) psychogene Schwindel - eine wichtige Teilkomponente bei wiederholten M. Menière-Anfällen. HNO 1999b: 47: 924-932.

Schaaf H, Nelting M, Hesse G. Schwindel - psychosomatisch gesehen. München, Wien: Profil, 1999c. Schaaf H. Bei M. Menière auch psychogene Schwindelanteile beachten. Dt Ärztebl 2000; 97: Ausg. B, Heft 3: 89.

Schaaf H, Holtmann H, Hesse G, et al. Reactive psychogenic dizziness in Menière's disease. In: Sterkers O, Ferrary E, Daumann R, Sauvage JP, Tran Ba Huy R, eds. Menière's disease 1999 - update. Proceedings of the Fourth International Symposium of Menière's disease, Paris, France, April 11-14, 1999. The Hague: Kugler, 2000a: 505-511.

Schaaf H, Seling B, Reyher A, et al. Is low frequency fluctuating hearing loss the first step to Menières disease? Fourth European Congress of Oto-Laryngo-logy, Head an Neck Surgery, May 13-18, 2000. Laryngo-rhinootologie 2000b; Suppl 1: 274. Schaaf H. Morbus Menière. Ein psychosomatisch orientierter Leitfaden. 3rd ed. Heidelberg: Springer, 2001a: 196.

Schaaf H. Psychogener Schwindel in der HNO-Heilkunde. Für die Praxis HNO 2001b; 49: 307-315.

Schaaf H. Seling B, Rienhoff NK, Laubert A, Nelting M, Hesse G.Sind rezidivierende TieftonHörverluste ohne Schwindel die Vorstufe eines M. Menière? HNO 2001; 7 (in press).

Schätz M. Chronischer Tinnitus und Somatoforme Störungen. Diplomarbeit Naturwissenschaftliche Universität Salzburg (W. Hiller), 1997.

Scherer H. Untersuchungsmethoden am vestibulären System. In: Naumann HH, Helms J, Herberhold C, Kastenbauer E, eds. Oto-Rhino-Laryngologie in Klinik und Praxis. Band 1: Ohr. Stuttgart: Thieme, 1994: 368-426.

Scherer H. Das Gleichgewicht. 2nd ed. Heidelberg: Springer, 1997. 370

Schilder P. The vestibular apparatus. In: Schilder P. Mind, perception and thought in their constructive aspects. New York: Columbia Univ Press, 1942: 83-134.

Schilkowsky G, Kröner-Herwig B, Frenzel A, Fritsche G, Mertin M. Die Wirksamkeit des Tinnitusbewältigungstrainings. In: Kröner-Herwig B, ed. Psychologische Behandlung des Tinnitus. Weinheim: Beltz, 1997: 115-122.

Schilter B. Therapie des chronischen Tinnitus; Metaanalyse zur Effektivität medikamentöser und psychologischer Therapien. Frankfurt: Verlag für Akademische Schriften, 2000.

Schilter,B., Jäger,B., Heermann,R., Lamprecht,F. (2000) Medikamentöse und psychologische Therapien bei chronischem subjektiven Tinnitus. HNO 48: 589-597

Schimpf R. Differentialdiagnostischer Vergleich von ambulant und stationär behandelten chronischen Tinnitusbetroffenen. Diplomarbeit Psych. Institut Univ. Hamburg (S. Tönnies), 1994.

Schleuning AJ, Johnson RM, Vernon JA. Evaluation of a tinnitus masking program: a followup study of 598 patients. Ear Hear 1980; 1(2): 71-74.

Schmidt AJM, van Roosmalen R, van der Beek JMH, Lousberg R. Hypochondriasis in ENT-practice. Clin Otolaryngol 1993; 18: 508-511.

Schmitt N. The Mainz Pain Staging System (MPSS) for chronic pain. Pain 1990; 5(Suppl.): 484.

Schneider WR, Hilk A, Franzen U. Soziale Unterstützung, Beschwerdedruck, Streßverarbeitung und Persönlichkeitsmerkmale bei Patienten mit subjektivem chronischen Tinnitus aurium und einer klinischen Kontrollgruppe. HNO 1994; 4: 22-27.

Schneider E. Psychodynamische Therapiegruppe und psychoedukatives Basisprogramm - ein Methodenvergleich bei Patienten mit chronischem dekompensierten Tinnitus. In: Hocker KM, ed. Methodenintegration in der Psychosomatischen Rehabilitation. Frankfurt am Main: Lang, 1996.

Schneider E, Hocker KM, Lebisch H, Pilgramm M. Does systematic noise stimulation improve tinnitus habituation? In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 391-393.

Schneider S, Margraf J. Fragebogen, Ratingskalen und Tagebücher für die verhaltenstherapeutische Praxis. In: Margraf J, ed. Lehrbuch der Verhaltenstherapie, Band 1. Berlin, Heidelberg, New York: Springer, 1996: 189-200.

Schönweiler R. Ohrgeräusche, Ursachen, Bewertungen und Therapie. DMW 1986; 111: 1489-1494.

Schönweiler R, Neuschulte C, Paar GH. Klagsamkeit und Depression bei Ohrgeräuschpatienten. Laryngorhinootologie 1989; 68: 267-270.

Schorn K. Allgemeine Untersuchungsmethoden. In: Naumann HH, Helms J, Herberhold C, Kastenbauer E, eds. Oto-Rhino-Laryngologie in Klinik und Praxis. Band 1: Ohr. Stuttgart: Thieme, 1994: 306-368.

Schorn K. Stand der audiologischen Diagnostik. In: Koch U, Theissing J, eds. Referate Verhandlungsbe-richt 1997 der Deutschen HNO-Gesellschaft. Berlin, Heidelberg, New York: Springer, 1997: 131-173.

Schubert HJ. Psychosoziale Faktoren bei Hauterkrankungen. Empirische Untersuchungen zu diagnostischen und therapeutischen Fragestellungen mit Hilfe zeitreihenanalytischer Methoden. Göttingen:Vandenhoeck & Schulte,D. (1999) Verhaltenstherapeutische Diagnostik. In: Reinecker,H., Borg-Laufs,M., Ehlert,U., Sogatz,H., Vogel,H. (Hrsg): Lehrbuch der Verhaltenstherapie, Dgvt-Verlag, Tübingen: 45-85 Ruprecht, 1989.

Schussler G, Geishauser E, Ruger U. Psychosomatische Faktoren beim idiopathischen Hörsturz. HNO 1992; 40: 4-9.

Schuhmann K. Pilgramm M. Das Knalltrauma und seine Bedeutung für die Bundeswehr. Wehrmed. Tagung, Oldenburg, 1985.

Schuhmann K, Lehnhardt EK, Lamm K, Hettich M. Zur Wirkung und Wirksamkeit der hyperbaren Sauerstofftherapie bei Hörstörungen. Bericht über 557 Fälle aus dem Jahre 1989. Vortrag auf der 94. Tagung der Vereinigung Westdeutscher HNO-Ärzte am 28.4. 1990 in Münster. (1990a)

Schuhmann K, Lamm K, Hettich M. Zur Wirkung und Wirksamkeit der hyperbaren Sauerstofftherapie bei alten Hörstörungen. HNO 1990b; 38: 408-411.

Schüller A. Die Schädelaufnahme im Röntgenbild. Archiv und Atlas der normalen und pathologischen Anatomie in typischen Röntgenbildern. Hamburg: Gräge & Sillem, 1905.

Schulte D. Wie soll Therapieerfolg gemessen werden? Übersichtsarbeit. Z Klin Psychol 1993; 4: 374-393.

Schulte W. Zur funktionellen Behandlung der Myoarthropathien des Kauorgans: ein diagnostisches und physiotherapeutisches Programm. Dtsch Zahnärztl Z 1970; 25: 422-449.

Schulte W. Gezielte Funktionsanalyse und Physio-Therapie - Erfahrungen bei 442 Patienten mit Myoarthropathien. Dtsch Zahnärztl Z 1972; 27: 779-795.

Schulte W. Die exzentrische Okklusion. Berlin: Quintessenz, 1983. Schultz JH. Das Autogene Training. Stuttgart: Thieme, 1952/1987.

Schur M. Comments on the metapsychology of somatization. Psa Study Child 1955; 10: 119-164.

Schüßler G, Geishauer E, Rüger U. Das Autogene Training, 7th ed. Stuttgart: Thieme, 1992.

Schwartz GE. Testing the biopsychosocial model: The ultimative challenge facing behavioural medicine? J Consult Clin Psychol 1982; 50: 1040-1053.

Schwartz MS. Biofeedback: A Practitioner's guide. New York: Guilford Press, 1995a.

Schwartz MS. Tinnitus: Nothing is as loud as a sound you are trying not to hear. In: Schwartz MS, ed. Biofeedback: a practitioner's guide. New York: Guilford Press, 1995b: 790-801.

Schwöbel G. Zur Psychotherapie des Schwindels. Psyche 1954; 8: 367-387. Scott J, Huskisson EC. Graphic representation of pain. Pain 1976; 2: 175-187.

Scott B, Lindberg P, Lyttkens L, Melin L. Psychological treatment of tinnitus. An experimental group study. Scand Audiol 1985; 14(4): 223-230.

Scott B, Lindberg P, Lyttkens L, Melin L. Predictors of tinnitus discomfort, adaptation and subjective loudness. Br J Audiol 1990; 24: 51-62.

Scott B, Lindberg P. Tinnitus-Inzidenz und ihre Auswirkungen. In: Goebel G, ed. Ohrgeräusche. Psychosomatische Aspekte des komplexen chronischen Tinnitus. München: Quintessenz, 1992: 41-51.

Scott B, Lindberg P. Psychological profile and somatic complaints between help-seeking and non-help-seeking tinnitus subjects. Psychosomatics 2000; 41: 347-52.

Scott,B, & Lindberg,P. (2991) Epidemiologie, Auswirkung und Klassifikation In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München: Seefeld B. TRT am Chiemsee. Was macht eine Hörakustikerin bei den Psychologen? Hörakustik 1999; 5: 96-98.

Seligmann M. Erlernte Hilflosigkeit. München: Urban & Schwarzenberg, 1986.

Semler G, Wittchen HU, Joschke K, et al. Test-retest reliability of a standardized psychiatric interview (DIS/CIDI). Eur Arch Psychiatry Neurol Sci 1987; 236: 214-222.

Senf W, Rad M v. Ergebnisforschung in der psychosomatischen Medizin. In: Üxküll T v, ed. Psychosoma-tische Medizin. München: Urban & Schwarzenberg, 1990.

Shehata-Dieler WE, Dieler R, Moser LM. Die Wirkung von Salicylaten und Chinin an den sensorischen Haar-zellen der Cochlea: ein Modell für Tinnitus. Arbeits-gemeinschaft Deutschsprachiger Audiologen und Neu-rootologen (ADANO), Arbeitstagung vom 20.3. bis 22.3. 1997 in Freiburg.

Sheldrake JB, Wood SM, Cooper HR. Practical aspects of the instrumental management of tinnitus. Br J Audiol 1985; 19(2): 147-150.

Sheldrake JB, Hazell JWP. Maskers versus hearing aids in prothethic management of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 395-399.

Sheldrake JB, Jastreboff PJ, Hazell JWP. Perspectives for total elimination of tinnitus perception. In: Proceedings of the Fifth International Tinnitus Seminar. Portland: American Tinnitus Association, 1996a: 531-536.

Sheldrake JB, McKinney CM, Hazell JWP. Practical aspects of retraining therapy. In: Reich GE, Vernon JA, eds. Proceeding of the Fifth International Tinnitus Seminar. American Tinnitus Association: Portland, 1996b: 537-538.

Sheldrake JB, Hazell JWP, Graham RL. An evaluation of the TRT method. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 99-105.

Shore NA. Occlusal equilibration and temporomandibular joint dysfunction. Philadelphia: Lippincott, 1959.

Shulman A, Goldstein B. Tinnitus masking - update 1977-1986. A longitudinal study of the efficacy of diagnosis and treatment using instrumentation. Proceedings of the Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987: 251-256.

Siedentopf CM - Neural correlates of transmeatal cochlear laser (TCL) stimulation in healthy human subjects.
Neurosci Lett. 2007 Jan 16;411(3):189-93. Epub 2006 Nov 22.
Siedentopf CM, Ischebeck A, Haala IA, Mottaghy FM, Schikora D, Verius M, Koppelstaetter F, Buchberger W, Schlager A, Felber SR, Golaszewski SM Department of Radiology II, Division of Neuroradiology, University Hospital of Innsbruck, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. christian.siedentopf@fmri-easy.de
(Sample of the text)

Simpson RB, Nedzelski JM, Barber HO, Thomas MR. Psychiatric diagnoses in patients with psychogenic dizziness or severe tinnitus. J Otolaryngol 1988; 17: 325-330.

Slater R, Terry M. Tinnitus: a guide for sufferers and professionals. Kent: Mackays of Chatham, 1987: 121ff.

Smith JA, Mennemeier M, Bartel T, Chelette KC, Kimbrell T, Triggs W, Dornhoffer JL
Repetitive transcranial magnetic stimulation for tinnitus: a pilot study.
Laryngoscope. 2007 Mar;117(3):529-34.
Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. (Sample of the text)

Smith P, Coles RRA. Epidemiology of tinnitus: an update. In: Feldmann H. Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987: 147-153.

Sokolov EN. Neuronal models and the orienting reflex. In: Brazier MA, ed. The central nervous system and behaviour. New York: Macy, 1960: 187-276.

Solberg WK, Flint RT, Brantner JP. Temporomandibular joint pain and dysfunction: a clinical study of emotional and occlusal components. J Prost Dent 1972; 28: 412-422.

Söllner W, Doering J. Psychologische Therapieverfahren bei chronischen nicht-radikulären Rückenschmerzen. Schmerz 1997; 6: 418-429.

Spielberger CD, Gorsuch RL, Luschere RE. STAI Manual for the Stait Trait Anxiety Inventory. Palo Alto: Consulting Psychologists Press, 1970.

Spoendlin H, Lichtensteiger W. The adrenergic innervation of the labyrinth. Acta Otolaryngol 1965; 61: 423-434.

Spoendlin H, Lichtensteiger W. The sympathetic nerve supply to the inner ear. Arch Klin Exp Ohren Nasen Kehlkopfheilkd 1967; 189(4): 346-359.

Spoendlin H. Inner ear pathology and tinnitus. In: Feldmann H. Proceedings of the Third International Tinnitus Seminar. Karlsruhe: Harsch, 1987: 42-51.

Stange G. Die Zukunft der Hörgeräteversorgung. Kolloquium beim VdAK in Sieburg. Schriftenreihe Geers-Stiftung (Essen) 1988; 7: 24-33.

Stange G. Exogene Faktoren akuter Hörminderungen. Laryngol Rhinol Otol 1972; 51: 494-498.

Stanton HE. The utilization of suggestions derived from rational-emotive therapy. Int J Clin Hypn 1977; 25: 18-26.

Stanton HE. Streßreduktion durch Rational-Emotive Therapie und Hypnoseinduktion. Exp Klin Hypn 1989; 5: 83-90.

Stephens SD, Corcoran AL. A controlled study of tinnitus masking. Br J Audiol 1985; 19(2): 159-167.

Stephens SDG. Personality tests in Menière's disorder. J Laryngol Otol 1975; 89: 479-490.

Stephens SDG. Evaluation of the problems of the hearing impaired. Audiology 1980; 19: 205-220

Stephens SDG. The treatment of tinnitus - a historical perspective. J Laryngol Otol 1984; 98: 963-972.

Stephens SDG, Hallam RS. The Crown-Crisp Ex-periential Index in patients complaining of tinnitus. Br J Audiol 1985; 19: 151-158.

Stephens D, Erlandsson S, Sanchez L, Hows D. Some psychological aspects of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 433-440.

Stevens JM. Some psychological problems of aquired deafness. Br J Psychiatry 1982; 140: 453-456.

Sternbach RA. Painpatients: traits and treatment. New York: Academic Press, 1974.

Sternbach RA. Psychologische Verfahren bei der Behandlung von Schmerz. In: Keeser W, Pöppel E, Mitterhusen P, eds. Schmerz: Fortschritte der klinischen Psychologie. München,Wien, Baltimore: Urban & Schwarzenberg, 1982: 284-295.

Steurer O. Lehrbuch der Hals-Nasen-Ohrenkrankheiten. München: Bergmann, 1948.

Stoll W, Matz D, Most E. Schwindel und Gleichgewichtsstörungen. Stuttgart: Thieme, 1992.

Stolze H. In: Schmidt, ed. Evaluation einer psychosomatischen Klinik. Frankfurt/Main: VAS, 1991.

Stormer CC Stenklev NC - Rock music and hearing disorders
[Article in Norwegian]
Tidsskr Nor Laegeforen 2007 Mar 29;127(7):874-7.
Institutt for klinisk medisin, Det medisinske fakultet, Universitetet i Tromso, 9037 Tromso.
carl.christian.lein.stormer@gmail.com (Sample of the text)

Stouffer JL, Tyler RS. Characterization of tinnitus by tinnitus sufferers. J Speech Hear Dis 1990; 55(3): 439-453.

Stouffer JL, Tylor RS, Booth JC, Buckrell B. Tinnitus in normal-hearing and hearing-impaired children. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux.Amsterdam, New York: Kugler, 1992.

Stouffer JL, Tyler RS, Kileny PR, Dalzell LE. Tinnitus as a function of duration and etiology: Counselling implications. Am J Otolaryngol 1991; 3: 188-193.

Sturmey P. Functional analysis in clinical psychology. Chichester: John Wiley & Sons, 1996.

Suinn RM. Anxiety management training for general anxiety. In: Suinn RM, Weigal RG, eds. The innovative psychological therapies. New York: Harper & Row, 1975.

Sullivan M, Katon W, Dobie R, Sakai C, Russo J, Harrop-Griffiths MB. Disabling tinnitus; association with affectice disorders. General Hospital Psychiatry 1988; 10: 285-291.

Sullivan M, Katon W, Russo J, Dobie R, Sakai C. Somatization, comorbidity and the quality of life: measuring the effect of depression upon chronic medical illness. Psychiatric Medicine 1992; 3: 61-76.

Sullivan M, Clark MR, Katon WJ, et al. Psychiatric and otologic diagnoses in patients complaining of dizziness. Arch Intern Med 1993 a; 153: 1479-1484.

Sullivan M, Katon W, Russo J, Dobie R, Sakai C. A randomized trial of nortriptyline for severe chronic tinnitus. Arch Intern Med 1993 b; 153: 1-9.

Sullivan M, Katon W, Russo J, Dobie R, Sakai C. Coping and marital support as correlates of tinnitus disability. Gen Hosp Psychiatry 1994; 16(4): 259-266.

Surr RK, Montgomery AA, Mueller HG. Effect of amplification on tinnitus among new hearing aid users. Ear Hear 1985; 6: 71-75.

Svitak M, Rief W, Goebel G, Hiller W, Schätz M, Fichter M. Somatization and chronic tinnitus. Internationales Symposium Somatoforme Störungen (Leitung PD W. Rief), Klinik Roseneck, 21.-23.2. 1997.

Svitak M. Psychosoziale Aspekte des chronisch dekompensierten Tinnitus. Psychische Komorbidität, Somatisierung, dysfunktionale Gedanken und psychosoziale Beeinträchtigung. Dissertation Psychologisches Institut der Univ. Salzburg (PD W. Rief), 1998.

Svitak M, Rief W, Schätz M, Biesinger E, Goebel G, Fichter M. Kognitive Aspekte der subjektiven Tinnitusbelastung. Poster 2. Psychotherapiekongreß der DGPPM 4.-7.3. 1998, Freiburg.

Svitak M, Rief W, Schätz M, Biesinger E, Goebel G, Fichter M. Kognitive Aspekte der subjektiven Tinnitusbelastung. Poster 16. Symposium für klinische Psychologische Forschung der Fachgruppe Klinische Psychologie der Deutschen Gesellschaft für Psychologie. 21.-23.5. 1998.

Svitak M, Rief W, Goebel G, Fichter M. Associations between tinnitus and psychological variables: the role of psychopathology, somatisation and dysfunctional cognitions. J Psychosom Res, accepted 1999.

Svitak,M., Rief,W., Goebel,G. (2001) Kognitive Therapie des chronischen dekompensierten Tinnitus. Der Psychotherapeut Sweetow RW. Cognitive behavioral modification in tinnitus management. Hearing Instruments 1984; 35; 14-19.

Sweetow R. Counseling the patient with tinnitus. Arch Otolaryngol 1985; 111: 283-284. 374

Sweetow R. Cognitive aspects of tinnitus patient management. Ear Hear 1986; 16: 390-396.

Sweetow R, Levy MC. Diagnostic and therapeutic Tinnitus Severity Scaling TSS. Tinnitus Today, the Journal of the American Tinnitus Association 1989; 3: 4-7.

Sweetow R, Levy MC. Tinnitus severity scaling for diagnostic/therapeutic usage. Hearing Instruments 1990a; 2: 20-21/46b.

Sweetow R, Levy MC. Tinnitus severity scaling for diagnostic and therapeutic usage. J Speech Hear Dis 1990b; 48: 150-155.

Szecsenyi J, Sandholzer H. Hörscreening-Studie. Audio Forum 1995; 1: 4-7.

Szecsenyi J, Sandholzer H. Hörstörungen in der Allgemeinpraxis. Eine Studie zur Früherkennung von Hörstörungen bei 500 hausärztlichen Patienten. Im Auftrag der Sektion Hören im Deutschen Grünen Kreuz. Marburg: Kilian, 1995.

T (back to top)

Terry AMP, Jones DM. Preference for potential tinnitus maskers: Results from annoyance ratings. Br J Audiol 1986; 20: 277-297.

Tesch-Römer C. Coping with hearing loss in old age. Paper presented at the 45th Annual Meeting of the Gerontological Society of America, New Orleans, 19.-23.11.1993.

Tesch-Römer C, Nowak M. Bewältigung einer Belastung des höheren Erwachsenenalters: Anpassung an ein Hörgerät. Poster 11. Tagung für Entwicklungspsychologie in Osnabrück; 28.-30.11. 1993.

Thimm L. Signale der Seele. Psychotherapie als Baustein zu ganzheitlichem Tinnitusverständnis. In: Hesse G, Nelting M, Schaaf H. Tinnitus: Leiden und Chance. München, Wien: Profil, 1997: 64-74.

Thomas AJ. Aquired hearing loss. Psychological and psychosocial implications. London: Academic Press, 1984.

Thomas M, Laurell G, Lundeberg T. Acupuncture for the alleviation of tinnitus. Laryngoscope 1988; 98: 664-667.

Tinnitus Klinik Bad Arolsen, K.I.M.M (DTL), ed. Die Menièresche Erkrankung: Schwindel, Tinnitus und Hörverlust. Ein Einstieg für Betroffene und Angehörige. Arolser Schriften IV. München, Wien: Profil, 1999.

Tomps on RC. Assyrian praescriptions for diseases of the ears. J Royal Asiatic Soc 1-22. Cited in: Feldmann H. Medizinhistorisches und Kulturhistorisches zum Tinnitus. Stuttgart: Thieme, 1992: 11.

Tonndorf J. Endolymphatic hydrops: mechanical causes of hearing loss. Arch Otorhinolaryngol 1976; 212: 293-299.

Tonndorf J. Acute cochlear disorder: the combination of hearing loss, recruitment, poor speech discrimination and tinnitus. Ann Otol Rhinol Laryngol 1980; 89: 353-358.

Tonndorf J. The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus. Hear Res 1987; 28: 271-275.

Tonndorf J. The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus. In: Vernon JA, Møller A, eds. Mechanisms of tinnitus. Boston, London, Toronto: Allyn and Bacon, 1995: 231-236.

Tönnies S. Selbsthilfemöglichkeiten für Tinnitusbetroffene. In: Fromberg J, ed. Rehabilitation Schwerhöriger, Ertaubter und Gehörloser. Komwestheim: Salamanderdruck, 1991: 125-132.

Tönnies S. Befragung von HNO-Ärzten zu Tinnitus. In: Goebel G, ed. Interdisziplinäre Diagnostik und Therapie des komplexen chronischen Tinnitus; II. Priener Tinnitus-Symposium. Düsseldorf: Verlag für Wissenschaft und Fortbildung, 1992: 3-5.

Tönnies S. Ambulante Gruppenbehandlung von jugendlichen Betroffenen. In: Richtberg W, Verch K, ed. Schwerhörige - Gehörlose - Ertaubte. Academia Verlag: St. Augustin, 1996.

Trassera J, Domené J, Fusté J, Carulla M, Trassera-Coderch J. Subjective and objective intensity of tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 193-194.

Tumarki n L. Otolithic catastrophe. A new syndrom. Br Med J 1936; 2: 175-177.

Turk DC, Meichenbaum DH, Genest M. Pain and behavioural medicine: a cognitive-behavioural perspective. New York: Guilford Press, 1983.

Türp JC. Zum Zusammenhang zwischen Myoarthropathien des Kausystems und Ohrbeschwerden (Otalgie, Tinnitus). HNO 1998; 46: 303-310.

Tursky B, Jammer LD, Friedmann R. The pain perception profile: a psychophysical approch to the assesment of pain report. Beh Ther 1982; 13: 376-394.

Tyler RS, Baker LJ. Difficulties experienced by tinnitus sufferers. J Speech Hear Dis 1983; 48: 150-154.

Tyl er RS, Conrad-Armes D. The determination of tinnitus loudness considering the effects of ecruitment. J Speech Hear Res 1983; 26: 59-72.

Tyler RS, Babin RW. Tinnitus. In: Cummings CW, Fredrickson JM, Harker L, Krause CJ, Schuller DE, eds. Otolaryngology. Head and Neck Surgery. St. Louis: Mosby, 1986.

Tyler RS, Stouffer JL. A review of tinnitus loudness. Hear J 1989; 42: 52-57.

Tyler RS. Evaluation of tinnitus treatments In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 552-553.

Tyler RS. 1992. Research needs for the treatment of tinnitus through instrumentation. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 357-361.

Tyler RS, Stouffer JL, Schum R. Audiological rehabilitation of the tinnitus client. Rehabilitation Audiological 1989; 22: 30-42.

U (back to top)

Uchida K, Kitahara M, Kodama A. Pitch match testing with simulated tinnitus sounds. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 35-38.

Ullrich de Muynck R, Ullrich R. Standardisierung des Selbstsicherheitstrainings für Gruppen (Assertiveness- Training-Programm: ATP). In: Brengelmann J, Tunner W, ed. Behavior therapy - Verhaltenstherapie. München: Urban & Schwarzenberg, 1973: 254-259.

V (back to top)

Vaitl D. Lebensqualität - Methoden zu ihrer objektiven Bestimmung. MMW 1990; 35: 521-522.

Veith A. Therapiemotivation: Zur Spezifizierung einer unspezifischen Therapievariablen. Obladen: Westdeutscher Verlag, 1997.

Ventry IM, Weinstein B. The Hearing Handicap Inventory for the Elderly: a new tool. Ear Hear 1982; 3; 128-134.

Vernon JA. The loudness (?) of tinnitus. Speech Hear Action 1976; 44: 17-19.

Vernon J. The other noise damage: Tinnitus. Sound and vibration 1978; 12(5): 26.

Vernon JA, Schleuning A. Tinnitus: a new management. Laryngoscope 1978; 88: 413-419.

Vernon J. The history of masking as applied to tinnitus. In: Tinnitus. Proceedings of the First International Tinnitus Seminar 1979. J Laryngol Otol; Suppl 4: 76-79.

Vernon JA. Assesment of the tinnitus patient. Hazell JWP, ed. Tinnitus. Edinburgh, London: Livingstone, 1987a: 59-72. Vernon JA. Pathophysiology of tinnitus: a special case - hyperacusis and a proposed treatment. Am J Otol 1987b; 8: 201-202.

Vernon J. The common errors of masking for relief of tinnitus. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar Münster. Karlsruhe: Harsch, 1987c: 229-238.

Vernon J, Wilson F, Mitchell C. Real-ear evaluation of tinnitus-masker. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar Münster. Karlsruhe: Harsch, 1987: 280-287.

Vernon JA, Møller AR, eds. Mechanisms of tinnitus. Boston, London, Toronto: Allyn and Bacon, 1995. 376

Vernon JA, Press L. Tinnitus in the elderly. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 289-290.

Vesterager V. Combined psychological and prosthetic management of tinnitus: a cross-sectional study of patients with severe tinnitus. Br J Audiol 1994; 28: 1-11.

Vesterager V, Nilsson P, Sibelle P. A programme for systematic treatment of tinnitus: A follow-up study. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 546-547.

Vesterhauge S, et al, eds. Ménière's disease. 16. Danavox Symposium, Kolding, 1996.

Voss R. Die Behandlung von Beschwerden des Kiefergelenks mit Aufbißplatten. Dtsch Zahnärztl Z 1964; 19: 545.

W (back to top)

Wackenheim A. Roentgen diagnosis of the cranio-vertebral region. Berlin, Heidelberg, New York: Springer, 1974.

Wageneder I. Die psychische Belastung bei Tinnitus. Psychologisches Institut der Univ. Salzburg (Diplomarbeit; Mackinger A, Greimel W), 1996.

Wagner U, Jordan J. Therapieerfolg bei stationärer psychosomatischer Krankenbehandlung. Z Allgemeine Medizin 1992; 68: 1030-1034.

Wallhäusser-Franke E, Braun S, Langner G. Salicylate alters 2-DG uptake in the auditory system; a model for tinnitus? Neuroreport 1996; 7: 1585-1588.

Wallhäusser-Franke E. Salicylate evokes c-fos expression in the brainstem: implications for tinnitus. Neuroreport 1997; 8: 725-728.

Wallhäusser-Franke E, Langner G. Central activation patterns after experimental tinnitus induction in an animal model. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 155-162.

Walsh WM, Gerley PP. Thermal biofeedback and the treatment of tinnitus. Laryngoscope 1985; 95: 987-989.

Walter B, Johansen PA. Effect of tinnitus masker. 5 years follow-up (Poster). In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987: 301-302.

Wangemann P. Kaliumsekretion und Entstehung des endokochlearen Potentials in der Stria vascularis. HNO 1997; 45: 205-209.

Wedel H von, Opitz HJ. Langzeittherapie von Tinnitus mit Hörgeräten und Tinnitus-Maskern - ein drei-jähriger Erfahrungsbericht. Arch Otorhinolaryngol 1983; Suppl: 254-259.

Wedel H von. A longitudinal study in tinnitus therapy with tinnitus maskers and hearing aids. In: Feldmann H, ed. Proceedings of the Third International Tinnitus Seminar, Münster. Karlsruhe: Harsch, 1987: 257-260.

Wedel H von. Tinnitustherapie mit Hörgeräten und Tinnitus-Maskern: Ergebnisse einer Langzeitstudie. Audiol Akustik 1988; 2: 34-44.

Wedel H von, Strahlmann U, Zorowka P. Effektivität verschiedener nicht medikamentöser Therapiemaßnahmen bei Tinnitus. Laryngorhinootologie 1989; 68: 259-266.

Wedel H von, Wedel UC von, Zorowka P. Tinnitus diagnosis and therapy in the aged. Acta Otolaryngol Suppl 1991; 476: 195-201.

Wedel H von, Wedel UC von. Tinnitusmasking in patients with severe sleep disturbances. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 381-386.

Wedel H von, Wedel UC von. Zur apparativen Versorgung von Tinnituspatienten mit Hörhilfen. HNO aktuell 1996a; 4: 112-118.

Wedel H von, Wedel UC von. Erste Erfahrungen mit der Retraining-Therapie bei Tinnitus. Vortrag auf der 67. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Aachen. HNO-Informationen 1996b; 4: 108.

Wedel H von, Walger M, Hoenen M, Calero L. Effectiveness of low-power-laser and gingko-therapy in patients with chronic tinnitus. In: Reich G, Vernon J, eds. Proceedings of the Fifth International Tinnitus Seminar 1995. Portland: American Tinnitus Association, 1996: 92-95.

Wedel H von, Wedel UC von, Streppel M, Walger M. Untersuchungen zur Effektivität partieller und kompletter apparativer Maskierung auf den chronischen Tinnitus im Hinblick auf den Einsatz der Retraining-Therapie. HNO 1997; 45(9): 690-694.

Wedel H von. Tinnitus-Retraining-Therapie aus neurophysiologischer Sicht. Referat Hörgeräte-Akustiker-Kongreß 1998: 63-74.

Wedel H von, Wedel VC von, Walger M. Tinnitus masking with tinnitus maskers and hearing aids - a longitudinal study of efficacy from 1987-1993. In: Vernon J, ed. Tinnitus - treatment and relief. Boston: Allyn and Bacon, 1998.

Wedel H von. Tinnitus-retraining-therapy - an up-date. Laryngorhinootologie 2000; (Suppl 1): 341.

Wedel H von, Wedel UC von, Streppel M, Walger M. A retrospective study of tinnitus retraining therapy efficacy compared to counseling alone and to additional behavioural therapy. Laryngorhinootologie 2000; (Suppl 1): 340.

von Wedel,H. (2001) Apparativ- akustische Therapie bei Tinnitus. In: Goebel,G. (Hrsg.): Ohrgeräusche. Psychosomatische Aspekte des chronischen Tinnitus. Urban & Vogel, München: 69-82

Weinaug P. Die Spontanremission beim Hörsturz. HNO 1984; 32: 346-351.

Weizsäcker V von. Pathosophie. Göttingen, 1956. Weitzenhoffer AM. Behaviour therapeutic techniques and hypnotherapeutic methods. Am J Clin Hypn 1972; 15: 71-82.

Westerlaken BO, de Kleine E, van der Laan B, Albers F
The treatment of idiopathic sudden sensorineural hearing loss using pulse therapy: a prospective, randomized, double-blind clinical trial.
Laryngoscope. 2007 Apr;117(4):684-90.
Department of Otorhinolaryngology, University Medical Center Groningen, The Netherlands. b.o.westerlaken@kno.umcg.nl (Sample of the text)

Wexler M, Crary W. Menières Disease: the psychosomatic hypothesis. Am J Otol 1986; 7: 93-96.

White TP, Hoffmann SR, Gale EN. Psychophysiological therapy for tinnitus. Ear Hear 1986; 7: 397-399. Wiehl P.Orale Physiotherapie - eine zusätzliche Hilfe für Myoarthropathie-Patienten. Schweiz. Mschr. Zahnheilk, 93: 235.

Wilhelm T, Ruh S, Bock K, Lenarz T. Standardisierung und Qualitätssicherung am Beispiel Tinnitus. Laryngorhinootologie 1995; 74: 300-306.

Wilson PH, Haralambous G, Ireland S, Platt-Hepworth S, Tonkin J.Psychological management of tinnitus: effects of relaxation training biofeedback. In: Feldmann H, ed. Tinnitus. Stuttgart: Thieme, 1987: 454-356

Wilson P, Henry J, Mowen M, Haralambous G. Tinnitus Reaction Questionnaire: psychometric properties of a measure of distress associated with tinnitus. J Speech Hear Res 1991; 34: 197-201.

Wilson PH. Relapse prevention: conceptual and methodological issues. In: Wilson PH, ed. Principles and practice of relapse prevention. New York: Guilford Press, 1992.

Wilson P, Bowen W, Farag P. Cognitive and relaxation techniques in the management of tinnitus. In: Aran JM, Dauman R, eds. Proceedings of the Fourth International Tinnitus Seminar, Bordeaux. Amsterdam, New York: Kugler, 1992: 489-491.

Wilson P, Henry J. Psychological approaches in the management of tinnitus. Aust J Otolaryngol 1993; 1: 296-302.

Wilson P, Henry J, Nicholas MK. Cognitive methods in the management of chronic pain and tinnitus. Aust Psychologist 1993; 28: 172-180.

Wilson P, Henry JL. Tinnitus Cognitions Questionnaire: development and psychometric properties of a measure of dysfunctional cognitions associated with tinnitus. Int Tinnitus J 1998; 4 (1): 23-30.

Wilson P, Henry JL, Andersson G, Hallam R, Lindberg P. A critical analysis of directive counselling as a component of tinnitus retraining therapy. A review paper. Br Soc Audiol 1998; 32: 273-286.

Wilson P. Critical analysis of TRT. Vortrag 3. Priener Tinnitus-Symposium 18.3.2000.

Wimmer J. Hilfe zur Selbsthilfe. Ein Therapie- und Übungsprogramm für Patienten mit subjektiven Ohrgeräuschen. Dissertation Univ. München (Prof. HH Naumann), 1983.

Winokur G, Black DW, Nasrallah A. Depression secondary in other psychiatric disorders and medical illnesses. Am J Psychiatry 1988; 145: 233-237. 378

Winter B, Nieschalk M, Stoll W. Die Auswirkung der Entspannungstherapie als Gruppen- und Einzelbehandlung bei chronischem Tinnitus. Psychother Psychosom Med Psychol 1995; 46: 147-152.

Wirsching M. Qualitätssicherung in der Psychosomatischen und Psychotherapeutischen Medizin. Möglichkeiten, Beispiele, Grenzen. Vortrag, gehalten auf dem Kolloquium "Qualitätssicherung in der Psychosomatischen und Psychotherapeutischen Medizin", Freiburg, 1992.

Wise K, Goebel G, Hiller W. Coping with tinnitus: a standardized group therapy programm. 26. Congress of the European Association for Behaviour and Cognitive Therapy (EABCT), 3.10.1996, Budapest.

Wise K, Rief W, Goebel G.Meeting the expectations of chronic tinnitus patients: comparison of a structured group therapy program for tinnitus management with a problem-solving group. J Psychosom Res 1998; 44: 681-685.

Wittchen HU, Saß H, Zaudig M, Köhler K, eds. Diagnostisches und Statistisches Manual Psychischer Störungen, DSM-III-R. Weinheim: Beltz, 1989.

Wittchen HU, Zaudig M, Fydrich T. Strukturiertes Klinisches Interview für DSM-IV (SKID-I und SKID-II). Göttingen: Hogrefe, 1997.

Wolpe J, Lazarus AA. Behaviour therapy techniques. Oxford: Pergamon Press, 1966.

Wright WH. Deafness as influenced by malposition of the jaws. J Nat Dent Ass 1920; 7: 979.

Wolff HD. Die Sonderstellung des Kopfgelenkbereiches. Berlin, Heidelberg, New York: Springer, 1988.

Wölk C, Seefeld B. The effects of mangaging hyperacusis with maskers (noise generators). In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 512-514.

Wood KA, Webb WL, Orchik DJ, Shea JJ. Intractable tinnitus: psychiatric aspects of treatment. Psychosomatics 1983; 24: 4.

Wooley SC. Physiology versus cognitive factors in short term food regulation in the obese and nonobese. Psychosom Med 1972; 34: 62-68.

X (back to top)

Y (back to top)

Yang G, Lobarinas E, Zhang L, Turner J, Stolzberg D, Salvi R, Sun W
Salicylate induced tinnitus: Behavioral measures and neural activity in auditory cortex of awake rats. Hear Res. 2007 Apr;226(1-2):244-53. Epub 2006 Aug 14.
Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, University at Buffalo, Buffalo, NY 14214, United States; Department of Otolaryngology, YueYang Hospital, Shanghai, China. (Sample of the text)

Yamakawa K. Über pathologische Veränderungen bei einem Menière-Kranken. J Otolaryngl Soc Jap 1938; 4: 2310-2312.

Yardley L, Masson E,Verschuur C, Luxon L, Haacke N. Symptoms, anxiety and handicap in dizzy patients: development of the Vertigo Symptom Scale. J Psychosom Res 36: 731-741.

Yardley L, Todd AM, Lacodraye-Harter MM, Ingham R. Psychosocial consequences of vertigo. Psychol Health 1992b; 6: 85-96.

Yardley L. Contribution of symptoms and beliefs to handicap in people with vertigo: a longitudinal study. Br J Clin Psychol 1994; 33: 101-113.

Yemm R. Neurophysiologic studies of temporomandibular joint dysfunction. In: Zarb GA, Carlsson GE, eds. Temporomandibular joint-function and dysfunction. Kopenhagen: Munksgaard, 1979: 214-237.

Z (back to top)

Zenner HP, Zimmermann U, Schmitt U. Reversible contraction of isolated mammalian cochlear hair cell. Hear Res 1985; 18: 127-133.

Zenner HP. Aktive Bewegung von Haarzellen: ein neuer Mechanismus beim Hörvorgang. HNO 1986; 34: 133-138.

Zenner HP. Cochlear hair cell metabolism: clinical aspects. In: Helms F, ed. Sensineuronal hearing loss and equlibrium disturbances. Stuttgart: Thieme, 1989: 7-12.

Zenner HP. Praktische Therapie von Hals-Nasen-Ohren- Krankheiten. Stuttgart: Schattauer, 1993a.

Zenner HP. Cochleäre Schwerhörigkeit; Hörsturz. In: Zenner HP, ed. Praktische Therapie von Hals-Nasen- Ohren-Krankheiten. Stuttgart: Schattauer, 1993b: 89-90.

Zenner HP. Akustischer Hörschaden, Lärmschwerhörigkeit. In: Zenner HP, ed. Praktische Therapie von Hals-Nasen-Ohren-Krankheiten. Stuttgart: Schattauer, 1993c: 92-93.

Zenner HP. statoacusticus; Akustikusneurinom. In: Zenner HP, ed. Praktische Therapie von Hals-Nasen-Ohren- Krankheiten. Stuttgart: Schattauer, 1993d: 136.

Zenner HP, Ernst A. Cochlear-motor, transduction and signal transfer tinnitus: model for three types of cochlear tinnitus. Eur Act Otolaryngol 1993e; 249: 447-454.

Zenner HP. Hören: Physiologie, Biochemie, Zell- und Neurobiologie. Stuttgart: Thieme, 1994.

Zenner HP, Ernst A. Cochlear motor tinnitus, transduction tinnitus and signal transfer tinnitus: three models of cochlear tinnitus. In: Vernon JA, Møller AR, eds. Mechanisms of tinnitus. Boston, London, Toronto: Allyn and Bacon, 1994: 237-254.

Zenner H, Pfister M. Systematic classification of tinnitus. In: Hazell J, ed. Proceedings of the Sixth International Tinnitus Seminar, Cambridge. London: Tinnitus and Hyperacusis Center, 1999: 17-19.

von Zerssen D. Die Beschwerdeliste, Manual Beltz-Test. Weinheim: Beltz, 1976.

back to top!

-------------------

General Info
(in English, German and French)

Tinnitus
Tinnitus is a problem of a great number of people...
(click here and read all)

Hyperacusis
More information about Hyperacusis will be presented soon....
(click here and read all)

Hearing Loss

Hearing loss is something that happens...
(click here and read all)

Meniéres disease
Menière’s disease is precisely describ...
(click here and read all)

Sudden deafness More information about Sudden deafness will be presented soon...
(click here and read all)

Psychological disorders combined with tinnitus